Clotrimazole as a potent agent for treating the oomycete fish pathogen Saprolegnia parasitica through inhibition of sterol 14α-demethylase (CYP51) (Q34261359)

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English	Clotrimazole as a potent agent for treating the oomycete fish pathogen Saprolegnia parasitica through inhibition of sterol 14α-demethylase (CYP51)	scientific article

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11 March 2020

Clotrimazole as a potent agent for treating the oomycete fish pathogen Saprolegnia parasitica through inhibition of sterol 14α-demethylase (CYP51) (English)

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11 March 2020

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Andrew Warrilow

1

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11 March 2020

author name string

Claire M Hull

2

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11 March 2020

Nicola J Rolley

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11 March 2020

Josie E Parker

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11 March 2020

W David Nes

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11 March 2020

Stephen N Smith

6

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11 March 2020

Diane E Kelly

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11 March 2020

Steven L Kelly

8

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1 August 2014

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11 March 2020

Applied and Environmental Microbiology

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11 March 2020

80

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11 March 2020

6154-6166

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11 March 2020

19

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11 March 2020

Identification, modeling and ligand affinity of early deuterostome CYP51s, and functional characterization of recombinant zebrafish sterol 14α-demethylase

1 reference

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6 July 2018

Distinctive expansion of potential virulence genes in the genome of the oomycete fish pathogen Saprolegnia parasitica

1 reference

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6 July 2018

Development and reproduction of Saprolegnia species in biofilms

1 reference

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6 July 2018

Prothioconazole and prothioconazole-desthio activities against Candida albicans sterol 14-α-demethylase

1 reference

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6 July 2018

Azole affinity of sterol 14α-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens

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6 July 2018

In vitro effect of malachite green on Candida albicans involves multiple pathways and transcriptional regulators UPC2 and STP2.

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6 July 2018

Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14α-Demethylase (CYP51) from Leishmania infantum

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6 July 2018

Mechanism of binding of prothioconazole to Mycosphaerella graminicola CYP51 differs from that of other azole antifungals

1 reference

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6 July 2018

Chitin synthases from Saprolegnia are involved in tip growth and represent a potential target for anti-oomycete drugs.

1 reference

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6 July 2018

Identification and characterization of four azole-resistant erg3 mutants of Candida albicans

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6 July 2018

Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.

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6 July 2018

Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51).

1 reference

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6 July 2018

A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B.

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6 July 2018

Structural basis for conservation in the CYP51 family

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6 July 2018

Phage therapy and photodynamic therapy: low environmental impact approaches to inactivate microorganisms in fish farming plants.

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6 July 2018

Expression and functional characterization of cytochrome P450 26A1, a retinoic acid hydroxylase

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6 July 2018

Sterol 14alpha-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth

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6 July 2018

Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms

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6 July 2018

Phytophthora Genome Sequences Uncover Evolutionary Origins and Mechanisms of Pathogenesis

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THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES

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6 July 2018

A kingdom-level phylogeny of eukaryotes based on combined protein data

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6 July 2018

Emergence of resistance of Candida albicans to clotrimazole in human immunodeficiency virus-infected children: in vitro and clinical correlations

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6 July 2018

Characterization and catalytic properties of the sterol 14alpha-demethylase from Mycobacterium tuberculosis

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6 July 2018

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6 July 2018

Kinetics of the reversible inhibition of enzyme-catalysed reactions by tight-binding inhibitors

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6 July 2018

Defective sterol C5-6 desaturation and azole resistance: a new hypothesis for the mode of action of azole antifungals

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6 July 2018

Expression and enzymatic activity of recombinant cytochrome P450 17 alpha-hydroxylase in Escherichia coli

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6 July 2018

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27 Measurement of substrate and inhibitor binding to microsomal cytochrome P-450 by optical-difference spectroscopy

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6 July 2018

Sterol metabolism in the oomycete Aphanomyces euteiches, a legume root pathogen

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28 October 2018

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CYP51 from Trypanosoma cruzi: a phyla-specific residue in the B' helix defines substrate preferences of sterol 14alpha-demethylase

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Morphological and biochemical alterations of oomycete fish pathogen Saprolegnia parasitica as affected by salinity, ascorbic acid and their synergistic action

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A Saprolegnia parasitica challenge system for rainbow trout: assessment of Pyceze as an anti-fungal agent for both fish and ova

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Oridamycins A and B, Anti-Saprolegnia parasiticaIndolosesquiterpenes Isolated fromStreptomycessp. KS84

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10.1128/AEM.01195-14

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11 March 2020

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11 March 2020

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11 March 2020

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