Foundations for the design and implementation of synthetic genetic circuits (Q34273084)

1 August 2017

title

Foundations for the design and implementation of synthetic genetic circuits (English)

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1 August 2017

Adrian L Slusarczyk

1

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1 August 2017

Allen Lin

series ordinal

2

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1 August 2017

Ron Weiss

series ordinal

3

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1 August 2017

publication date

18 May 2012

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1 August 2017

published in

Nature Reviews Genetics

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1 August 2017

volume

13

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1 August 2017

issue

6

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1 August 2017

page(s)

406-420

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Construction of a genetic toggle switch in Escherichia coli

1 August 2017

cites work

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A synthetic oscillatory network of transcriptional regulators

21 January 2018

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Synthetic biology: integrated gene circuits

21 January 2018

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Synthetic biology moving into the clinic

21 January 2018

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Synthetic biology: applications come of age

21 January 2018

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Neocortical excitation/inhibition balance in information processing and social dysfunction

21 January 2018

1 reference

21 January 2018

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DNA assembly for synthetic biology: from parts to pathways and beyond.

21 January 2018

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Production of the antimalarial drug precursor artemisinic acid in engineered yeast

21 January 2018

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Programming cells by multiplex genome engineering and accelerated evolution

21 January 2018

1 reference

A synthetic mammalian gene circuit reveals antituberculosis compounds

21 January 2018

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The second wave of synthetic biology: from modules to systems

21 January 2018

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Computer-aided organic synthesis

21 January 2018

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Computational design approaches and tools for synthetic biology

21 January 2018

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Automatic compilation from high-level biologically-oriented programming language to genetic regulatory networks

21 January 2018

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Strategies for protein synthetic biology.

21 January 2018

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Protein folds and functions

21 January 2018

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Independent and tight regulation of transcriptional units in Escherichia coli via the LacR/O, the TetR/O and AraC/I1-I2 regulatory elements

21 January 2018

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In vivo repression by a site-specific DNA-binding protein designed against an oncogenic sequence

21 January 2018

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The discovery of zinc fingers and their applications in gene regulation and genome manipulation.

21 January 2018

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Breaking the code of DNA binding specificity of TAL-type III effectors

21 January 2018

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A simple cipher governs DNA recognition by TAL effectors

21 January 2018

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Plant science. DNA binding made easy.

21 January 2018

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Regulation of selected genome loci using de novo-engineered transcription activator-like effector (TALE)-type transcription factors

21 January 2018

1 reference

21 January 2018

Synthetic RNA circuits

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21 January 2018

RNA synthetic biology

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Automated design of synthetic ribosome binding sites to control protein expression

21 January 2018

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Directed evolution of a genetic circuit

21 January 2018

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A tunable genetic switch based on RNAi and repressor proteins for regulating gene expression in mammalian cells

21 January 2018

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A universal RNAi-based logic evaluator that operates in mammalian cells

21 January 2018

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Logic integration of mRNA signals by an RNAi-based molecular computer

21 January 2018

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Multi-input RNAi-based logic circuit for identification of specific cancer cells

21 January 2018

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Versatile RNA-sensing transcriptional regulators for engineering genetic networks

21 January 2018

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Applications of aptamers as sensors

21 January 2018

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Functional aptamers and aptazymes in biotechnology, diagnostics, and therapy

21 January 2018

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A modular and extensible RNA-based gene-regulatory platform for engineering cellular function

21 January 2018

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Higher-order cellular information processing with synthetic RNA devices

21 January 2018

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A ligand-dependent hammerhead ribozyme switch for controlling mammalian gene expression

21 January 2018

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Forty years of in vitro evolution

21 January 2018

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Reprogramming cellular behavior with RNA controllers responsive to endogenous proteins

21 January 2018

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An RNA aptamer that induces transcription

21 January 2018

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Rewiring the specificity of two-component signal transduction systems

21 January 2018

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Synthetic biology: engineering Escherichia coli to see light

21 January 2018

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Multichromatic control of gene expression in Escherichia coli

21 January 2018

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The promise of optogenetics in cell biology: interrogating molecular circuits in space and time.

21 January 2018

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The development and application of optogenetics

21 January 2018

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Millisecond-timescale, genetically targeted optical control of neural activity

21 January 2018

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Spatiotemporal control of cell signalling using a light-switchable protein interaction.

21 January 2018

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A genetically encoded photoactivatable Rac controls the motility of living cells

21 January 2018

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Temporally precise in vivo control of intracellular signalling

21 January 2018

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Light-activated kinases enable temporal dissection of signaling networks in living cells

21 January 2018

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Chemical and genetic engineering of selective ion channel-ligand interactions

21 January 2018

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Engineered GPCRs as tools to modulate signal transduction

21 January 2018

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Directed molecular evolution of DREADDs: a generic approach to creating next-generation RASSLs

21 January 2018

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Designing customized cell signalling circuits

21 January 2018

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21 January 2018

Making cellular memories

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A comparative analysis of synthetic genetic oscillators

21 January 2018

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Development of genetic circuitry exhibiting toggle switch or oscillatory behavior in Escherichia coli

21 January 2018

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A fast, robust and tunable synthetic gene oscillator.

21 January 2018

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A synchronized quorum of genetic clocks

21 January 2018

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A tunable synthetic mammalian oscillator

21 January 2018

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An engineered epigenetic transgene switch in mammalian cells

21 January 2018

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Design and construction of a double inversion recombination switch for heritable sequential genetic memory

21 January 2018

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Synthetic gene networks that count

21 January 2018

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Engineering microbial consortia: a new frontier in synthetic biology

21 January 2018

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Engineering multicellular systems by cell-cell communication.

21 January 2018

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A synthetic multicellular system for programmed pattern formation

21 January 2018

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Sequential establishment of stripe patterns in an expanding cell population

21 January 2018

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Programmed population control by cell-cell communication and regulated killing.

21 January 2018

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Synthetic ecosystems based on airborne inter- and intrakingdom communication

21 January 2018

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Robust multicellular computing using genetically encoded NOR gates and chemical 'wires'.

21 January 2018

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A synthetic genetic edge detection program.

21 January 2018

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Dual selection enhances the signaling specificity of a variant of the quorum-sensing transcriptional activator LuxR.

21 January 2018

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Cell to cell communication by autoinducing peptides in gram-positive bacteria

21 January 2018

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Cell-cell communication in gram-positive bacteria

21 January 2018

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Characterization of combinatorial patterns generated by multiple two-component sensors in E. coli that respond to many stimuli

21 January 2018

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Use of two-component signal transduction systems in the construction of synthetic genetic networks

21 January 2018

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Synthetic cooperation in engineered yeast populations

21 January 2018

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A synthetic metabolite-based mammalian inter-cell signaling system

21 January 2018

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Gas-inducible transgene expression in mammalian cells and mice

21 January 2018

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Construction of an artificial intercellular communication network using the nitric oxide signaling elements in mammalian cells

21 January 2018

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Artificial cell-cell communication in yeast Saccharomyces cerevisiae using signaling elements from Arabidopsis thaliana

21 January 2018

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Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms

21 January 2018

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Engineering synthetic signaling proteins with ultrasensitive input/output control

21 January 2018

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Using engineered scaffold interactions to reshape MAP kinase pathway signaling dynamics

21 January 2018

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Rapid diversification of cell signaling phenotypes by modular domain recombination

21 January 2018

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Network motifs: theory and experimental approaches

21 January 2018

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Combinatorial synthesis of genetic networks

21 January 2018

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Deriving structure from evolution: metazoan segmentation

21 January 2018

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Design of genetic networks with specified functions by evolution in silico.

21 January 2018

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Diversity-based, model-guided construction of synthetic gene networks with predicted functions

21 January 2018

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Design and connection of robust genetic circuits

21 January 2018

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Noise and robustness in prokaryotic regulatory networks

21 January 2018

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Cellular decision making and biological noise: from microbes to mammals

21 January 2018

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Distributed biological computation with multicellular engineered networks

21 January 2018

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Modular cell biology: retroactivity and insulation

21 January 2018

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MicroRNAs can generate thresholds in target gene expression

21 January 2018

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A synthetic optogenetic transcription device enhances blood-glucose homeostasis in mice

21 January 2018

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Environmentally controlled invasion of cancer cells by engineered bacteria

21 January 2018

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Synthetic gene circuits: design with directed evolution

21 January 2018

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Kemp elimination catalysts by computational enzyme design

21 January 2018

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Computational method to reduce the search space for directed protein evolution

21 January 2018

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Novel methods for directed evolution of enzymes: quality, not quantity

21 January 2018

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The Logic of Chemical Synthesis: Multistep Synthesis of Complex Carbogenic Molecules(Nobel Lecture)

21 January 2018

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Computer-assisted analysis in organic synthesis

21 January 2018

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Selecting and screening recombinant antibody libraries

21 January 2018

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Picomolar affinity fibronectin domains engineered utilizing loop length diversity, recursive mutagenesis, and loop shuffling

21 January 2018

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DARPins and other repeat protein scaffolds: advances in engineering and applications

21 January 2018

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Rationally designed logic integration of regulatory signals in mammalian cells

21 January 2018

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Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting

21 January 2018

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A TALE nuclease architecture for efficient genome editing

21 January 2018

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Ultrafast optogenetic control.

21 January 2018

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Combinatorial biosynthesis of reduced polyketides

21 January 2018

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De novo computational design of retro-aldol enzymes

21 January 2018

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De novo enzyme design using Rosetta3

21 January 2018

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BioLogic gates enable logical transcription control in mammalian cells

21 January 2018

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A synthetic low-frequency mammalian oscillator

21 January 2018

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Intron length increases oscillatory periods of gene expression in animal cells

21 January 2018

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The theory of facilitated variation

21 January 2018

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Genomic cis-regulatory logic: experimental and computational analysis of a sea urchin gene

21 January 2018

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A combinatorial polymer library approach yields insight into nonviral gene delivery

21 January 2018

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The NK model of rugged fitness landscapes and its application to maturation of the immune response

21 January 2018

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Towards programming languages for genetic engineering of living cells

21 January 2018

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21 January 2018

Writing DNA with GenoCAD

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PROMOT: modular modeling for systems biology

21 January 2018

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SynBioSS: the synthetic biology modeling suite

21 January 2018

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TinkerCell: modular CAD tool for synthetic biology

21 January 2018

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Genetdes: automatic design of transcriptional networks.

21 January 2018

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OptCircuit: an optimization based method for computational design of genetic circuits

21 January 2018

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Mfold web server for nucleic acid folding and hybridization prediction

21 January 2018

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COPASI--a COmplex PAthway SImulator

21 January 2018

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Gene Designer: a synthetic biology tool for constructing artificial DNA segments

21 January 2018

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GeneDesign: rapid, automated design of multikilobase synthetic genes

21 January 2018

1 reference

Developer's and user's guide to Clotho v2.0 A software platform for the creation of synthetic biological systems

21 January 2018

1 reference

Synthetic biology: understanding biological design from synthetic circuits

21 January 2018

1 reference

Controlling protein activity with ligand-regulated RNA aptamers

31 March 2020

1 reference

A synthetic Escherichia coli predator-prey ecosystem

31 March 2020

1 reference

Harnessing the biosynthetic code: combinations, permutations, and mutations

31 March 2020

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Robustness analysis and tuning of synthetic gene networks

31 March 2020

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Engineering GPCR signaling pathways with RASSLs

31 March 2020

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PubMed

https://pubmed.ncbi.nlm.nih.gov/22596318

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRG3227

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Dimensions Publication ID

1 August 2017

1040647858

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