A greatly extended PPARGC1A genomic locus encodes several new brain-specific isoforms and influences Huntington disease age of onset (Q34275231)

1 August 2017

A greatly extended PPARGC1A genomic locus encodes several new brain-specific isoforms and influences Huntington disease age of onset (English)

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1 August 2017

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7

Markus Paulmichl

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Thomas K Felder

object named as

Thomas K Felder

2

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P. Weydt

9

object named as

Patrick Weydt

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1 August 2017

Bernhard Landwehrmeyer

8

object named as

G Bernhard Landwehrmeyer

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1 August 2017

Selma M Soyal

1

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1 August 2017

Simon Auer

3

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1 August 2017

Penelope Hahne

4

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1 August 2017

Hannes Oberkofler

5

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1 August 2017

Anke Witting

6

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1 August 2017

Markus Paulmichl

7

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1 August 2017

Wolfgang Patsch

10

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1 August 2017

European Huntington Disease Network

11

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1 August 2017

15 May 2012

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1 August 2017

Human Molecular Genetics

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1 August 2017

21

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1 August 2017

15

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1 August 2017

3461-3473

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A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis

1 August 2017

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

The Drosophila PGC-1 homologue Spargel coordinates mitochondrial activity to insulin signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Metabolic control through the PGC-1 family of transcription coactivators

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

PGC-1alpha: a potent transcriptional cofactor involved in the pathogenesis of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

PGC-1α at the intersection of bioenergetics regulation and neuron function: from Huntington's disease to Parkinson's disease and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

The role of PGC-1α in the pathogenesis of neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Peroxisome proliferator activator receptor gamma coactivator-1alpha (PGC-1α) improves motor performance and survival in a mouse model of amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

The gene coding for PGC-1alpha modifies age at onset in Huntington's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

PGC-1alpha as modifier of onset age in Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Localization of sequence variations in PGC-1α influence their modifying effect in Huntington disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Association of PGC-1alpha polymorphisms with age of onset and risk of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Expansion of the eukaryotic proteome by alternative splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Alternative isoform regulation in human tissue transcriptomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Genome-wide analysis of mammalian promoter architecture and evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Characterization of novel peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) isoform in human liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Isoform-specific increases in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to beta2-adrenergic receptor activation and exercise

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Two new splice variants in porcine PPARGC1A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Alternative mRNA splicing produces a novel biologically active short isoform of PGC-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

NT-PGC-1α protein is sufficient to link β3-adrenergic receptor activation to transcriptional and physiological components of adaptive thermogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Truncated peroxisome proliferator-activated receptor-γ coactivator 1α splice variant is severely altered in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

The human genome browser at UCSC

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

ExPASy: The proteomics server for in-depth protein knowledge and analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

PGC-1, a versatile coactivator

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Regulation of nuclear localization during signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Regulation of NT-PGC-1alpha subcellular localization and function by protein kinase A-dependent modulation of nuclear export by CRM1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Modeling and E-M estimation of haplotype-specific relative risks from genotype data for a case-control study of unrelated individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Score tests for association between traits and haplotypes when linkage phase is ambiguous

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Dysfunction of the cholesterol biosynthetic pathway in Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Cholesterol metabolism in Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

The complex language of chromatin regulation during transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Z-DNA-binding proteins can act as potent effectors of gene expression in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA forming microsatellite.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Activation of PPARgamma coactivator-1 through transcription factor docking

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

RNA polymerase III drives alternative splicing of the potassium channel-interacting protein contributing to brain complexity and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Sporadic ALS has compartment-specific aberrant exon splicing and altered cell-matrix adhesion biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Observing Huntington's disease: the European Huntington's Disease Network's REGISTRY.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Trinucleotide repeat length instability and age of onset in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

Associations of the UCP2 gene locus with asymptomatic carotid atherosclerosis in middle-aged women.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDS177

21 January 2018

Identifiers

DOI

10.1093/HMG/DDS177

1 reference

1 August 2017

1 reference