Dichloroacetate enhances apoptotic cell death via oxidative damage and attenuates lactate production in metformin-treated breast cancer cells (Q34285099)

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English	Dichloroacetate enhances apoptotic cell death via oxidative damage and attenuates lactate production in metformin-treated breast cancer cells	scientific article

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scholarly article

1 reference

Europe PubMed Central

1 August 2017

Dichloroacetate enhances apoptotic cell death via oxidative damage and attenuates lactate production in metformin-treated breast cancer cells (English)

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Europe PubMed Central

1 August 2017

apoptotic process

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dichloroacetate

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based on heuristic

inferred from title

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based on heuristic

inferred from title

object named as

Joseph D Coppock

3

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author name string

Allison B Haugrud

1

1 reference

Europe PubMed Central

1 August 2017

Yongxian Zhuang

2

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Europe PubMed Central

1 August 2017

W Keith Miskimins

4

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Europe PubMed Central

1 August 2017

language of work or name

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publication date

12 September 2014

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Europe PubMed Central

1 August 2017

Breast Cancer Research and Treatment

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Europe PubMed Central

1 August 2017

147

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Europe PubMed Central

1 August 2017

3

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Europe PubMed Central

1 August 2017

539-550

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Europe PubMed Central

1 August 2017

https://scigraph.springernature.com/pub.10.1007/s10549-014-3128-y

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Metformin induces both caspase-dependent and poly(ADP-ribose) polymerase-dependent cell death in breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184194

6 July 2018

Mitochondrial and plasma membrane lactate transporter and lactate dehydrogenase isoform expression in breast cancer cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184194

6 July 2018

Metabolic modulation of glioblastoma with dichloroacetate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184194

6 July 2018

gammaH2AX: a sensitive molecular marker of DNA damage and repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184194

6 July 2018

Drug combination studies and their synergy quantification using the Chou-Talalay method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184194

6 July 2018

New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184194

6 July 2018

Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184194

6 July 2018

Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184194

6 July 2018

Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27Kip1 or p21Cip1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184194

6 July 2018

Role of dichloroacetate in the treatment of genetic mitochondrial diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184194

6 July 2018

PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184194

6 July 2018

The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

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6 July 2018

Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184194

6 July 2018

Dual antiglioma action of metformin: cell cycle arrest and mitochondria-dependent apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184194

6 July 2018

Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184194

6 July 2018

Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184194

6 July 2018

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184194

6 July 2018

Tumor-derived lactic acid modulates dendritic cell activation and antigen expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184194

6 July 2018

Growing roles for the mTOR pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184194

6 July 2018

Breast carcinomas fulfill the Warburg hypothesis and provide metabolic markers of cancer prognosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184194

6 July 2018

Lactate in solid malignant tumors: potential basis of a metabolic classification in clinical oncology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184194

6 July 2018

On the Origin of Cancer Cells

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6 July 2018

The mitochondrion in apoptosis: how Pandora's box opens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184194

6 July 2018

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184194

6 July 2018

Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184194

6 July 2018

Dichloroacetate in the treatment of lactic acidosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184194

6 July 2018

Effect of metformin on glucose metabolism in the splanchnic bed

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4184194

6 July 2018

On the origin of cancer.

1 reference

https://api.crossref.org/works/10.1007%2FS10549-014-3128-Y

21 January 2018

HIV infections acquired through heterosexual intercourse in the United Kingdom: findings from national surveillance

1 reference

https://api.crossref.org/works/10.1007%2FS10549-014-3128-Y

21 January 2018

Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERalpha negative MDA-MB-435 breast cancer model

1 reference

https://api.crossref.org/works/10.1007%2FS10549-014-3128-Y

21 January 2018

Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species

1 reference

https://api.crossref.org/works/10.1007%2FS10549-014-3128-Y

21 January 2018

Metformin promotes isolated rat liver mitochondria impairment.

1 reference

https://api.crossref.org/works/10.1007%2FS10549-014-3128-Y

21 January 2018

Metformin-induced stimulation of AMP-activated protein kinase in beta-cells impairs their glucose responsiveness and can lead to apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS10549-014-3128-Y

21 January 2018

Dichloroacetate treatment for mitochondrial cytopathy: long-term effects in MELAS.

1 reference

https://api.crossref.org/works/10.1007%2FS10549-014-3128-Y

21 January 2018

Lactate dehydrogenase 5 expression in squamous cell head and neck cancer relates to prognosis following radical or postoperative radiotherapy

1 reference

https://api.crossref.org/works/10.1007%2FS10549-014-3128-Y

21 January 2018

Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer.

1 reference

https://api.crossref.org/works/10.1007%2FS10549-014-3128-Y

21 January 2018

Sensitization of metformin-cytotoxicity by dichloroacetate via reprogramming glucose metabolism in cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25212175

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitory effect of tumor cell-derived lactic acid on human T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25212175

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MnSOD expression is less frequent in tumour cells of invasive breast carcinomas than in in situ carcinomas or non-neoplastic breast epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25212175

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/25212175

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1007/S10549-014-3128-Y

1 reference

Europe PubMed Central

1 August 2017

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1 reference

Europe PubMed Central

1 August 2017

1 reference

Europe PubMed Central

1 August 2017

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