Human DNA polymerase-eta, an A-T mutator in somatic hypermutation of rearranged immunoglobulin genes, is a reverse transcriptase (Q34310763)

1 August 2017

Human DNA polymerase-eta, an A-T mutator in somatic hypermutation of rearranged immunoglobulin genes, is a reverse transcriptase (English)

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1 August 2017

4

Edward J Steele

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1 August 2017

3

Robert V Blanden

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1 August 2017

Andrew Franklin

1

1 reference

PubMed ID

15061777

1 August 2017

Peter J Milburn

series ordinal

2

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1 August 2017

1 April 2004

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Immunology & Cell Biology

1 August 2017

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1 August 2017

82

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1 August 2017

2

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1 August 2017

219-225

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Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

1 August 2017

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

21 January 2018

Somatic hypermutation

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https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Hypothesis: somatic hypermutation by gene conversion via the error prone DNA----RNA----DNA information loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Distribution of mutations around rearranged heavy-chain antibody variable-region genes

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Somatic hypermutation in 5' flanking regions of heavy chain antibody variable regions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

The reverse transcriptase model of somatic hypermutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Mechanism of antigen-driven somatic hypermutation of rearranged immunoglobulin V(D)J genes in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

The Y-family of DNA polymerases

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Eukaryotic DNA Polymerases

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

The expanding polymerase universe

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Error-prone repair DNA polymerases in prokaryotes and eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

hRAD30 mutations in the variant form of xeroderma pigmentosum

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Low fidelity DNA synthesis by human DNA polymerase-eta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Error rate and specificity of human and murine DNA polymerase eta

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase eta during copying of a mouse immunoglobulin kappa light chain transgene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Somatic mutation hotspots correlate with DNA polymerase eta error spectrum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

The absence of DNA polymerase kappa does not affect somatic hypermutation of the mouse immunoglobulin heavy chain gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Mechanisms of accurate translesion synthesis by human DNA polymerase eta

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Ultrasensitive retrovirus detection by a reverse transcriptase assay based on product enhancement

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Reverse transcription of mRNA by Thermus aquaticus DNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Nomenclature of Eukaryotic DNA Polymerases

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Structure of the catalytic core of S. cerevisiae DNA polymerase eta: implications for translesion DNA synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Poleta

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Physical and functional interactions of human DNA polymerase eta with PCNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Fidelity and processivity of Saccharomyces cerevisiae DNA polymerase eta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

AID mediates hypermutation by deaminating single stranded DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

21 January 2018

DNA repair in eukaryotes

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Excision of deaminated cytosine from the vertebrate genome: role of the SMUG1 uracil-DNA glycosylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Effects of endogenous DNA base lesions on transcription elongation by mammalian RNA polymerase II. Implications for transcription-coupled DNA repair and transcriptional mutagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

RNA editing by base deamination: more enzymes, more targets, new mysteries

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

RNA editing by adenosine deaminases that act on RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Widespread inosine-containing mRNA in lymphocytes regulated by ADAR1 in response to inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Genesis of the strand-biased signature in somatic hypermutation of rearranged immunoglobulin variable genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Reverse transcription of R2Bm RNA is primed by a nick at the chromosomal target site: a mechanism for non-LTR retrotransposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Cotranscriptionally Formed DNA:RNA Hybrids Mediate Transcription Elongation Impairment and Transcription-Associated Recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

What role for AID: mutator, or assembler of the immunoglobulin mutasome?

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

The role of polymerase eta in somatic hypermutation determined by analysis of mutations in a patient with xeroderma pigmentosum variant

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Exposure of normal and transformed cells to nevirapine, a reverse transcriptase inhibitor, reduces cell growth and promotes differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

A non-retroviral RNA virus persists in DNA form

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

Origin of Antibody Variation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.0818-9641.2004.01221.X

10.1046/J.0818-9641.2004.01221.X

21 January 2018

Identifiers

DOI

1 reference

1 August 2017

1 reference

PubMed ID

15061777