Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-deficient mice (Q34312762)

1 August 2017

title

Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-deficient mice. (English)

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1 August 2017

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James L Smart

1

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1 August 2017

Virginie Tolle

series ordinal

2

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1 August 2017

Malcolm J Low

series ordinal

3

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1 August 2017

language of work or name

English

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publication date

26 January 2006

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Journal of Clinical Investigation

1 August 2017

published in

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1 August 2017

volume

116

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1 August 2017

issue

2

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1 August 2017

page(s)

495-505

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Role of proopiomelanocortin neurons and peptides in the regulation of energy homeostasis.

1 August 2017

cites work

1 reference

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Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36).

6 July 2018

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Responsiveness to peripherally administered melanocortins in lean and obese mice

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A major health hazard: the metabolic syndrome

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Lack of proopiomelanocortin peptides results in obesity and defective adrenal function but normal melanocyte pigmentation in the murine C57BL/6 genetic background

6 July 2018

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Adrenalectomy stimulates hypothalamic proopiomelanocortin expression but does not correct diet-induced obesity

6 July 2018

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A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth

6 July 2018

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Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

6 July 2018

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Integrated control of appetite and fat metabolism by the leptin-proopiomelanocortin pathway

6 July 2018

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Obesity and the regulation of energy balance

6 July 2018

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Adrenalectomy reverses obese phenotype and restores hypothalamic melanocortin tone in leptin-deficient ob/ob mice

6 July 2018

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A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors

6 July 2018

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Obesity and insulin resistance

6 July 2018

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In vivo and in vitro ob gene expression and leptin secretion in rat adipocytes: evidence for a regional specific regulation by sex steroid hormones

6 July 2018

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Characterization of the neuroanatomical distribution of agouti-related protein immunoreactivity in the rhesus monkey and the rat.

6 July 2018

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Gender-dependent characteristics of the hypothalamo-corticotrope axis function in glucocorticoid-replete and glucocorticoid-depleted rats

6 July 2018

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A frameshift mutation in human MC4R is associated with a dominant form of obesity

6 July 2018

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A frameshift mutation in MC4R associated with dominantly inherited human obesity

6 July 2018

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Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

6 July 2018

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Central infusion of melanocortin agonist MTII in rats: assessment of c-Fos expression and taste aversion

6 July 2018

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Glucocorticoids as counterregulatory hormones of leptin: toward an understanding of leptin resistance

6 July 2018

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Targeted disruption of the melanocortin-4 receptor results in obesity in mice

6 July 2018

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Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

6 July 2018

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Rat and mouse proopiomelanocortin gene sequences target tissue-specific expression to the pituitary gland but not to the hypothalamus of transgenic mice

6 July 2018

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Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake

6 July 2018

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Effect of adrenalectomy and corticosterone replacement on meal patterns of Zucker rats

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1350998

Effect of adrenalectomy and glucocorticoid replacement on development of obesity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1350998

Adrenalectomy and steroid treatment in obese (ob/ob) and diabetic (db/db) mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1350998

Adrenalectomy and response to corticosterone and MSH in the genetically obese yellow mouse

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1350998

Effects of MSH on food intake, body weight and coat color of the yellow obese mouse

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1350998

Glucocorticoids as modulators in the control of feeding.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1350998

Effect of adrenalectomy and high-fat diet on the fatty Zucker rat

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1350998

Intraventricular corticosterone increases the rate of body weight gain in underweight adrenalectomized rats

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1350998

Development of Cushing's syndrome in corticotropin-releasing factor transgenic mice

6 July 2018

1 reference

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Energy Expenditure and Fuel Selection in Biological Systems: The Theory and Practice of Calculations Based on Indirect Calorimetry and Tracer Methods

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1350998

Effect of adrenalectomy on weight gain and body composition of yellow obese mice (Ay/a)

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1350998

Corticosterone in drinking water: altered kinetics of a single oral dose of corticosterone and concentrations of plasma sodium, albumin, globulin, and total protein

6 July 2018

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A homozygous null mutation delineates the role of the melanocortin-4 receptor in humans.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1350998

Adrenalectomy alters the sensitivity of the central nervous system melanocortin system.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1350998

Altered glucose homeostasis in proopiomelanocortin-null mouse mutants lacking central and peripheral melanocortin

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1350998

Exploring the site of anorectic action of peripherally administered synthetic melanocortin peptide MT-II in rats

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1350998

A spoonful of sugar: feedback signals of energy stores and corticosterone regulate responses to chronic stress

28 October 2018

1 reference

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A Role for the Endogenous Opioid β-Endorphin in Energy Homeostasis

28 October 2018

1 reference

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Selective reward deficit in mice lacking beta-endorphin and enkephalin.

28 October 2018

1 reference

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Inactivation of the GR in the nervous system affects energy accumulation

28 October 2018

1 reference

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The leptin-like effects of 3-d peripheral administration of a melanocortin agonist are more marked in genetically obese Zucker (fa/fa) than in lean rats

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1350998

Effects of acute and chronic administration of the melanocortin agonist MTII in mice with diet-induced obesity

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1350998

The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations : distinct metabolic effects of two fat compartments.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1350998

Chronic application of MTII in a rat model of obesity results in sustained weight loss

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1350998

Rapid nongenomic E2 effects on p42/p44 MAPK, activator protein-1, and cAMP response element binding protein in rat white adipocytes

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1350998

Central but not peripheral glucocorticoid infusion in adrenalectomized male rats increases basal and substrate-induced insulinemia through a parasympathetic pathway

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1350998

Induction of obesity and hyperleptinemia by central glucocorticoid infusion in the rat.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1350998

Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1350998

Scaling of metabolic rate on body mass in small laboratory mammals

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1350998

Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin

28 October 2018

1 reference

12 December 2020

Effect of intracerebroventricular alpha-MSH on food intake, adiposity, c-Fos induction, and neuropeptide expression

1 reference

12 December 2020

A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse

1 reference

12 December 2020

Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

1 reference

12 December 2020

Melanocortin 4 receptor gene variation is associated with severe obesity in Pima Indians

1 reference

12 December 2020

Hyperphagia, not hypometabolism, causes early onset obesity in melanocortin-4 receptor knockout mice

1 reference

12 December 2020

Body fat distribution measured with CT: correlations in healthy subjects, patients with anorexia nervosa, and patients with Cushing syndrome

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI25243

1 reference

1 August 2017

1 reference

1 August 2017

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