High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio (Q34359196)

1 August 2017

High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio (English)

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1 August 2017

11

Nils-Göran Larsson

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1 August 2017

3

Stefan Brené

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1 August 2017

5

Mügen Terzioglu

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1 August 2017

Jaime M Ross

1

1 reference

1 August 2017

Johanna Öberg

2

1 reference

1 August 2017

Giuseppe Coppotelli

4

1 reference

1 August 2017

Karin Pernold

6

1 reference

1 August 2017

Michel Goiny

7

1 reference

1 August 2017

Rouslan Sitnikov

8

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1 August 2017

Jan Kehr

9

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1 August 2017

Aleksandra Trifunovic

10

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1 August 2017

Barry J Hoffer

12

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1 August 2017

Lars Olson

13

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1 August 2017

language of work or name

English

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publication date

1 November 2010

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1 August 2017

6

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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1 August 2017

107

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1 August 2017

20087-20092

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1 August 2017

46

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Somatic mitochondrial DNA mutations in mammalian aging

1 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

The mtDNA mutator mouse: Dissecting mitochondrial involvement in aging

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

MitoPark mice mirror the slow progression of key symptoms and L-DOPA response in Parkinson's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Differential age-related changes in mitochondrial DNA repair activities in mouse brain regions

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Evidence for the mitochondrial lactate oxidation complex in rat neurons: demonstration of an essential component of brain lactate shuttles

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Lactate fuels the human brain during exercise

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Inhibition of monocarboxylate transporter 2 in the retrotrapezoid nucleus in rats: a test of the astrocyte-neuron lactate-shuttle hypothesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

A coherent neurobiological framework for functional neuroimaging provided by a model integrating compartmentalized energy metabolism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Neuronal-glial glucose oxidation and glutamatergic-GABAergic function.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Brain lactate kinetics: Modeling evidence for neuronal lactate uptake upon activation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Early markers of retinal degeneration in rd/rd mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Lactate: the ultimate cerebral oxidative energy substrate?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Highly resolved in vivo 1H NMR spectroscopy of the mouse brain at 9.4 T.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Premature ageing in mice expressing defective mitochondrial DNA polymerase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Magnetic resonance spectroscopy: neurochemistry and treatment effects in affective disorders.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Calorie restriction enhances the expression of key metabolic enzymes associated with protein renewal during aging

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

The genetics and pathology of oxidative phosphorylation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Cytochrome c oxidase deficient cells accumulate in the hippocampus and choroid plexus with age.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

6 July 2018

Mitochondria and ageing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Cerebrospinal fluid lactate levels and aging: findings in normals and patients with major depressive disorders.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Lactic dehydrogenase isozymes of the brain. I. Electrophoretic studies on regional distribution and ontogenesis.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Normal concentrations of lactate, glucose, and protein in cerebrospinal fluid, and the diagnotic implications of abnormal concentrations

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

The biologic clock: the mitochondria?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Mitochondrial genetics: a paradigm for aging and degenerative diseases?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Evolution of a gene. Multiple genes for LDH isozymes provide a model of the evolution of gene structure, function and regulation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

The human brain utilizes lactate via the tricarboxylic acid cycle: a 13C-labelled microdialysis and high-resolution nuclear magnetic resonance study.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Metabonomic alterations in hippocampus, temporal and prefrontal cortex with age in rats.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Blood lactate is an important energy source for the human brain.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Somatic mtDNA mutations cause progressive hearing loss in the mouse.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

The retrograde response links metabolism with stress responses, chromatin-dependent gene activation, and genome stability in yeast aging.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Long-lived Ames dwarf mouse exhibits increased antioxidant defense in skeletal muscle

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Standardized quantitative in situ hybridization using radioactive oligonucleotide probes for detecting relative levels of mRNA transcripts verified by real-time PCR.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Accumulation of point mutations in mitochondrial DNA of aging mice

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Late-onset corticohippocampal neurodepletion attributable to catastrophic failure of oxidative phosphorylation in MILON mice.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Enhanced gluconeogenesis and increased energy storage as hallmarks of aging in Saccharomyces cerevisiae

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993405

Lactate dehydrogenase isoenzymes a comparison of pyruvate-to-lactate and lactate-to-pyruvate assays

27 October 2018

1 reference

12 December 2020

Elevation of cerebrospinal fluid lactate with aging in subjects with normal blood oxygen saturations

1 reference

12 December 2020

Brain temperature modulations during global ischemia fail to influence extracellular lactate levels in rats

1 reference

12 December 2020

Multiple deletions are detectable in mitochondrial DNA of aging mice

1 reference

12 December 2020

High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys

1 reference

12 December 2020

SERUM LACTIC DEHYDROGENASE ACTIVITY: AN ANALYTICAL ASSESSMENT OF CURRENT ASSAYS

1 reference

12 December 2020

Differential messenger RNA distribution of lactate dehydrogenase LDH-1 and LDH-5 isoforms in the rat brain

1 reference

12 December 2020

DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1008189107

1 reference

release_q7zbg7i66rhpxpvay7ywsav35m

1 August 2017

0 references

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/q7zbg7i66rhpxpvay7ywsav35m

24 November 2022

mapped directly with Wikidata item

PMCID

2993405

1 reference

1 August 2017

1 reference