Functional Selectivity in Adrenergic and Angiotensin Signaling Systems (Q34359586)

1 August 2017

7 references

31 July 2019

17 November 2019

20 November 2019

15 December 2019

19 December 2019

26 August 2020

2 September 2020

Functional selectivity in adrenergic and angiotensin signaling systems (English)

1 reference

1 August 2017

Functional Selectivity in Adrenergic and Angiotensin Signaling Systems (English)

1 reference

Crossref

DOI

10.1124/MOL.110.067066

https://api.crossref.org/works/10.1124/MOL.110.067066

17 July 2024

main subject

cell surface receptor

1 reference

31 July 2019

1 reference

17 November 2019

1 reference

20 November 2019

1 reference

15 December 2019

1 reference

19 December 2019

1 reference

26 August 2020

1 reference

2 September 2020

Nabila Noor

2

1 reference

1 August 2017

Chetan B. Patel

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20855464

17 July 2024

Howard A. Rockman

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20855464

17 July 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20855464

17 July 2024

publication date

20 September 2010

1 reference

full work available at URL

1 August 2017

1 December 2010

7 references

31 July 2019

17 November 2019

20 November 2019

15 December 2019

19 December 2019

26 August 2020

2 September 2020

https://europepmc.org/articles/pmc2993470?pdf=render

file format

Portable Document Format

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20855464

http://molpharm.aspetjournals.org/cgi/content/abstract/78/6/983

17 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20855464

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20855464/pdf/?tool=EBI

17 July 2024

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Portable Document Format

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20855464

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20855464/?tool=EBI

17 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20855464

https://europepmc.org/articles/PMC2993470

17 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20855464

https://europepmc.org/articles/PMC2993470?pdf=render

17 July 2024

file format

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content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20855464

https://doi.org/10.1124/mol.110.067066

17 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20855464

https://syndication.highwire.org/content/doi/10.1124/mol.110.067066

17 July 2024

1 reference

Crossref

DOI

10.1124/MOL.110.067066

https://api.crossref.org/works/10.1124/MOL.110.067066

17 July 2024

published in

Molecular Pharmacology

8 references

1 August 2017

31 July 2019

17 November 2019

20 November 2019

15 December 2019

19 December 2019

26 August 2020

2 September 2020

78

1 reference

1 August 2017

issue

6

1 reference

1 August 2017

page(s)

983-992

1 reference

Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR).

1 August 2017

cites work

1 reference

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beta-Arrestin-biased agonism of the angiotensin receptor induced by mechanical stress

6 July 2018

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Teaching old receptors new tricks: biasing seven-transmembrane receptors

6 July 2018

1 reference

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beta-Arrestin-dependent activation of Ca(2+)/calmodulin kinase II after beta(1)-adrenergic receptor stimulation

6 July 2018

1 reference

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Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery

6 July 2018

1 reference

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Quantitative phosphoproteomics dissection of seven-transmembrane receptor signaling using full and biased agonists

6 July 2018

1 reference

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Genetic deletion of p90 ribosomal S6 kinase 2 alters patterns of 5-hydroxytryptamine 2A serotonin receptor functional selectivity

6 July 2018

1 reference

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'7TM receptor allostery: putting numbers to shapeshifting proteins

6 July 2018

1 reference

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Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor

6 July 2018

1 reference

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{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation

6 July 2018

1 reference

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Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation.

6 July 2018

1 reference

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Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors.

6 July 2018

1 reference

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A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure

6 July 2018

1 reference

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beta-arrestin-biased agonism at the beta2-adrenergic receptor

6 July 2018

1 reference

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A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling

6 July 2018

1 reference

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Mitogenic signaling pathways induced by G protein-coupled receptors

6 July 2018

1 reference

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Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection.

6 July 2018

1 reference

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The evasive nature of drug efficacy: implications for drug discovery

6 July 2018

1 reference

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Functional specialization of beta-arrestin interactions revealed by proteomic analysis

6 July 2018

1 reference

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Integrating signals from RTKs to ERK/MAPK.

6 July 2018

1 reference

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Structure and conformational changes in the C-terminal domain of the beta2-adrenoceptor: insights from fluorescence resonance energy transfer studies

6 July 2018

1 reference

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Beta-arrestins and cell signaling

6 July 2018

1 reference

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Real-time optical recording of beta1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol

6 July 2018

1 reference

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Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes

6 July 2018

1 reference

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Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy

6 July 2018

1 reference

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Functional Selectivity and Classical Concepts of Quantitative Pharmacology

6 July 2018

1 reference

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G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer

6 July 2018

1 reference

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Growth factor signaling regulates elongation of RNA polymerase I transcription in mammals via UBF phosphorylation and r-chromatin remodeling

6 July 2018

1 reference

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beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor

6 July 2018

1 reference

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Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice.

6 July 2018

1 reference

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New concepts in drug discovery: collateral efficacy and permissive antagonism

6 July 2018

1 reference

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Transduction of receptor signals by beta-arrestins

6 July 2018

1 reference

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Monitoring agonist-promoted conformational changes of beta-arrestin in living cells by intramolecular BRET.

6 July 2018

1 reference

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Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling

6 July 2018

1 reference

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Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor

6 July 2018

1 reference

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Principles: receptor theory in pharmacology

6 July 2018

1 reference

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Agonist and inverse agonist actions of beta-blockers at the human beta 2-adrenoceptor provide evidence for agonist-directed signaling

6 July 2018

1 reference

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Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.

6 July 2018

1 reference

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Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.

6 July 2018

1 reference

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Ligand-selective receptor conformations revisited: the promise and the problem

6 July 2018

1 reference

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Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK.

6 July 2018

1 reference

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The Role of a Conserved Region of the Second Intracellular Loop in AT1 Angiotensin Receptor Activation and Signaling

6 July 2018

1 reference

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Effect of carvedilol on the morbidity of patients with severe chronic heart failure: results of the carvedilol prospective randomized cumulative survival (COPERNICUS) study

6 July 2018

1 reference

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Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol

6 July 2018

1 reference

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Seven-transmembrane-spanning receptors and heart function

6 July 2018

1 reference

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Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy

6 July 2018

1 reference

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Inverse, protean, and ligand-selective agonism: matters of receptor conformation

6 July 2018

1 reference

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Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes

6 July 2018

1 reference

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The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor

6 July 2018

1 reference

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Effects of controlled-release metoprolol on total mortality, hospitalizations, and well-being in patients with heart failure: the Metoprolol CR/XL Randomized Intervention Trial in congestive heart failure (MERIT-HF). MERIT-HF Study Group

6 July 2018

1 reference

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Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors.

6 July 2018

1 reference

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Regulation of carbamoyl phosphate synthetase by MAP kinase

6 July 2018

1 reference

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G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization

6 July 2018

1 reference

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Cell type-specific angiotensin II-evoked signal transduction pathways: critical roles of Gbetagamma subunit, Src family, and Ras in cardiac fibroblasts

6 July 2018

1 reference

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Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.

6 July 2018

1 reference

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Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

6 July 2018

1 reference

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Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases

6 July 2018

1 reference

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Lack of association between adrenergic receptor genotypes and survival in heart failure patients treated with carvedilol or metoprolol

6 July 2018

1 reference

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Effects of AGTR1 A1166C gene polymorphism in patients with heart failure treated with candesartan

27 October 2018

1 reference

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The angiotensin type 1 receptor activates extracellular signal-regulated kinases 1 and 2 by G protein-dependent and -independent pathways in cardiac myocytes and langendorff-perfused hearts.

27 October 2018

1 reference

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Relation of beta(2)-adrenoceptor haplotype to risk of death and heart transplantation in patients with heart failure

27 October 2018

1 reference

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PKA-mediated phosphorylation of the beta1-adrenergic receptor promotes Gs/Gi switching

27 October 2018

1 reference

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β1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure

27 October 2018

1 reference

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The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation

27 October 2018

1 reference

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Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor

27 October 2018

1 reference

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Anti-apoptotic versus pro-apoptotic signal transduction: checkpoints and stop signs along the road to death.

27 October 2018

1 reference

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Beta2-adrenergic receptor genotype and survival among patients receiving beta-blocker therapy after an acute coronary syndrome

27 October 2018

1 reference

12 December 2020

Myocardial beta1-adrenergic receptor polymorphisms affect functional recovery after ischemic injury

1 reference

12 December 2020

Angiotensin II sensitivity is associated with the angiotensin II type 1 receptor A(1166)C polymorphism in essential hypertensives on a high sodium diet

1 reference

12 December 2020

The Angiotensin II Type 1 Receptor Gene Polymorphism Is Associated With Coronary Artery Vasoconstriction

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12 December 2020

Identifiers

DOI

10.1124/MOL.110.067066

1 reference

1 August 2017

1 reference

1 August 2017

1 reference