Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F. (Q34393383)

1 August 2017

Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F. (English)

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1 August 2017

Hershko T

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1 August 2017

Chaussepied M

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1 August 2017

Oren M

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1 August 2017

Ginsberg D

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1 August 2017

language of work or name

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1 April 2005

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Cell Death & Differentiation

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12

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1 August 2017

377-383

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https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401575

1 August 2017

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E2F1 pathways to apoptosis

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7 January 2021

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis

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7 January 2021

p53 and E2F-1 cooperate to mediate apoptosis

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7 January 2021

E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis.

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7 January 2021

E2F-1 blocks terminal differentiation and causes proliferation in transgenic megakaryocytes

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7 January 2021

E2F-1-induced p53-independent apoptosis in transgenic mice.

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7 January 2021

Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development

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7 January 2021

E2F-1 functions in mice to promote apoptosis and suppress proliferation

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

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7 January 2021

E2F1 induces phosphorylation of p53 that is coincident with p53 accumulation and apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

7 January 2021

ARF differentially modulates apoptosis induced by E2F1 and Myc.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

7 January 2021

p19(ARF) is dispensable for oncogenic stress-induced p53-mediated apoptosis and tumor suppression in vivo

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

7 January 2021

ARF is not required for apoptosis in Rb mutant mouse embryos

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

7 January 2021

ATM is a target for positive regulation by E2F-1.

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7 January 2021

Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

7 January 2021

E2F-1:DP-1 induces p53 and overrides survival factors to trigger apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

7 January 2021

p53: puzzle and paradigm

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

7 January 2021

ASPP proteins specifically stimulate the apoptotic function of p53

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

7 January 2021

A novel cofactor for p300 that regulates the p53 response

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

7 January 2021

p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

7 January 2021

iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

7 January 2021

The N-terminus of a novel isoform of human iASPP is required for its cytoplasmic localization.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

7 January 2021

Molecular and functional characterization of the stress-induced protein (SIP) gene and its two transcripts generated by alternative splicing. SIP induced by stress and promotes cell death

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

7 January 2021

P53-dependent expression of the stress-induced protein (SIP).

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7 January 2021

TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

7 January 2021

CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

7 January 2021

Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

7 January 2021

p14ARF links the tumour suppressors RB and p53.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

7 January 2021

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

7 January 2021

PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

7 January 2021

The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

7 January 2021

The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

7 January 2021

ASPP1 and ASPP2: common activators of p53 family members

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

7 January 2021

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

7 January 2021

Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

7 January 2021

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

7 January 2021

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

7 January 2021

Apaf-1 is a transcriptional target for E2F and p53

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

7 January 2021

PUMA, a novel proapoptotic gene, is induced by p53

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

7 January 2021

PUMA induces the rapid apoptosis of colorectal cancer cells

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

7 January 2021

Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

7 January 2021

The proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

7 January 2021

Expression analysis using DNA microarrays demonstrates that E2F-1 up-regulates expression of DNA replication genes including replication protein A2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401575

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4401575

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Dimensions Publication ID

1 August 2017

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