The Triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic-acid Methyl Ester Has Potent Anti-diabetic Effects in Diet-induced Diabetic Mice and Lepr Mice (Q34412580)

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scientific article published on October 18, 2010

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English	The Triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic-acid Methyl Ester Has Potent Anti-diabetic Effects in Diet-induced Diabetic Mice and Lepr Mice	scientific article published on October 18, 2010

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scholarly article

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2 August 2017

The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and Lepr(db/db) mice (English)

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The Triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic-acid Methyl Ester Has Potent Anti-diabetic Effects in Diet-induced Diabetic Mice and Lepr Mice (English)

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Marina Konopleva

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Marina Konopleva

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Michael Andreeff

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Michael Andreeff

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Lawrence Chan

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Pradip K. Saha

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Vasumathi T. Reddy

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https://doi.org/10.1074/jbc.m110.176545

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Journal of Biological Chemistry

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285

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52

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40581-40592

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Europe PubMed Central

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LKB1-dependent signaling pathways

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Induction of redox imbalance and apoptosis in multiple myeloma cells by the novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid.

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Obesity is associated with macrophage accumulation in adipose tissue

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LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

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MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

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Role of AMP-activated protein kinase in mechanism of metformin action

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Cancer Research

3

54

701

author name string

Huang

publication date

1994

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Cancer Research

4

48

5210

author name string

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1988

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Cancer Research

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717

author name string

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publication date

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Cancer Research

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59

336

author name string

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publication date

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Cancer Research

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author name string

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Cancer Research

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61

1533

author name string

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American Journal of Physiology

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277

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author name string

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