The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and Lepr(db/db) mice (Q34412580)

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English	The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and Lepr(db/db) mice	scientific article

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scholarly article

1 reference

Europe PubMed Central

2 August 2017

The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and Lepr(db/db) mice (English)

1 reference

Europe PubMed Central

2 August 2017

Marina Konopleva

3

object named as

Marina Konopleva

1 reference

Europe PubMed Central

2 August 2017

Michael Andreeff

4

object named as

Michael Andreeff

1 reference

Europe PubMed Central

2 August 2017

author name string

Pradip K Saha

1

1 reference

Europe PubMed Central

2 August 2017

Vasumathi T Reddy

2

1 reference

Europe PubMed Central

2 August 2017

Lawrence Chan

5

1 reference

Europe PubMed Central

2 August 2017

language of work or name

0 references

publication date

18 October 2010

1 reference

Europe PubMed Central

2 August 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

2 August 2017

285

1 reference

Europe PubMed Central

2 August 2017

52

1 reference

Europe PubMed Central

2 August 2017

40581-40592

1 reference

Europe PubMed Central

2 August 2017

Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide

1 reference

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Feed-forward signaling of TNF-alpha and NF-kappaB via IKK-beta pathway contributes to insulin resistance and coronary arteriolar dysfunction in type 2 diabetic mice

1 reference

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A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin

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Apoptotic activity and mechanism of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic-acid and related synthetic triterpenoids in prostate cancer

1 reference

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Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells.

1 reference

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PPARgamma-active triterpenoid CDDO enhances ATRA-induced differentiation in APL.

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CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer binding protein alpha

1 reference

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Synthetic triterpenoids inhibit growth and induce apoptosis in human glioblastoma and neuroblastoma cells through inhibition of prosurvival Akt, NF-kappaB and Notch1 signaling

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Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP.

1 reference

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LKB1-dependent signaling pathways

1 reference

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A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells

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The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

1 reference

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Adiponectin represses gluconeogenesis independent of insulin in hepatocytes

1 reference

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Inflammation, stress, and diabetes

1 reference

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Inhibition of mitochondrial respiration by nitric oxide rapidly stimulates cytoprotective GLUT3-mediated glucose uptake through 5'-AMP-activated protein kinase

1 reference

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Regulation of glucose transport by the AMP-activated protein kinase

1 reference

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Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR.

1 reference

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Growth-inhibitory effect of a novel synthetic triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, on ovarian carcinoma cell lines not dependent on peroxisome proliferator-activated receptor-gamma expression

1 reference

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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

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LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

1 reference

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Induction of redox imbalance and apoptosis in multiple myeloma cells by the novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid.

1 reference

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Obesity is associated with macrophage accumulation in adipose tissue

1 reference

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LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

1 reference

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MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

1 reference

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Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

1 reference

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AMP-activated protein kinase, super metabolic regulator

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Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome

1 reference

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Role of AMP-activated protein kinase in mechanism of metformin action

1 reference

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Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth

1 reference

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A synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), is a ligand for the peroxisome proliferator-activated receptor gamma

1 reference

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Obesity and insulin resistance

1 reference

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Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators

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Metabolic stress and altered glucose transport: activation of AMP-activated protein kinase as a unifying coupling mechanism

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Chemoprevention of cancer

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AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes

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A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity.

1 reference

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The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?

1 reference

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Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport.

1 reference

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Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages

1 reference

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Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

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Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assay

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Insulin activation of acetyl-CoA carboxylase accompanied by inhibition of the 5'-AMP-activated protein kinase

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The novel triterpenoid C-28 methyl ester of 2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid inhibits metastatic murine breast tumor growth through inactivation of STAT3 signaling.

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Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase

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Identifiers

10.1074/JBC.M110.176545

1 reference

Europe PubMed Central

2 August 2017

1 reference

Europe PubMed Central

2 August 2017

1 reference

Europe PubMed Central

2 August 2017

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