IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells. (Q34420821)

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16 January 2020

title

IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells (English)

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16 January 2020

4

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Patrick Caplazi

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Cecile King

12

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Stuart Tangye

13

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Nico Ghilardi

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16 January 2020

author name string

Marcel Batten

1

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Nandhini Ramamoorthi

2

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Noelyn M Kljavin

3

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Jennifer H Cox

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Hart S Dengler

6

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Dimitry M Danilenko

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Melanie Wong

9

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16 January 2020

David A Fulcher

10

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Matthew C Cook

11

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Frederic J de Sauvage

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16 January 2020

language of work or name

English

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publication date

22 November 2010

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Journal of Experimental Medicine

16 January 2020

published in

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volume

207

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16 January 2020

page(s)

2895-2906

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issue

13

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Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling.

16 January 2020

cites work

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IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism

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IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

6 July 2018

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New insights into the differentiation and function of T follicular helper cells.

6 July 2018

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Type I interferon signaling in dendritic cells stimulates the development of lymph-node-resident T follicular helper cells

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Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells

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The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding

6 July 2018

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Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities

6 July 2018

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Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors

6 July 2018

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A fundamental role for interleukin-21 in the generation of T follicular helper cells

6 July 2018

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Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages

6 July 2018

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ICOS controls the pool size of effector-memory and regulatory T cells.

6 July 2018

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6 July 2018

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6 July 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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IFN-alpha regulates Toll-like receptor-mediated IL-27 gene expression in human macrophages

21 January 2018

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IFN-beta modulates the response to TLR stimulation in human DC: involvement of IFN regulatory factor-1 (IRF-1) in IL-27 gene expression.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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12 December 2020

IL-27 induces a Th1 immune response and susceptibility to experimental arthritis

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12 December 2020

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12 December 2020

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Identifiers

DOI

10.1084/JEM.20100064

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21098093%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

0 references

1 reference

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16 January 2020

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