The transcriptional profile of mesenchymal stem cell populations in primary osteoporosis is distinct and shows overexpression of osteogenic inhibitors (Q34428195)

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English	The transcriptional profile of mesenchymal stem cell populations in primary osteoporosis is distinct and shows overexpression of osteogenic inhibitors	scientific article

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9 March 2020

The transcriptional profile of mesenchymal stem cell populations in primary osteoporosis is distinct and shows overexpression of osteogenic inhibitors (English)

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mesenchymal stem cell

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based on heuristic

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Ludger Klein-Hitpass

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Ludger Klein-Hitpass

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Peggy Benisch

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Tatjana Schilling

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Sönke P Frey

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Lothar Seefried

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Nadja Raaijmakers

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Melanie Krug

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Martina Regensburger

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Sabine Zeck

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Thorsten Schinke

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Michael Amling

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Franz Jakob

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24 September 2012

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e45142

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Creative Commons Attribution 4.0 International

24 September 2012

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0 references

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Retinoic acid-induced Smad3 expression is required for the induction of osteoblastogenesis of mesenchymal stem cells

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Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk

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Mouse genome-wide association and systems genetics identify Asxl2 as a regulator of bone mineral density and osteoclastogenesis

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Osteoporosis: now and the future

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Bivariate association analysis in selected samples: application to a GWAS of two bone mineral density phenotypes in males with high or low BMD.

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EGFR signaling suppresses osteoblast differentiation and inhibits expression of master osteoblastic transcription factors Runx2 and Osterix.

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TGF-β regulates β-catenin signaling and osteoblast differentiation in human mesenchymal stem cells

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Molecular silencing of Twist1 enhances osteogenic differentiation of murine mesenchymal stem cells: implication of FGFR2 signaling.

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How to track cellular aging of mesenchymal stromal cells?

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Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength

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Serum sclerostin levels negatively correlate with parathyroid hormone levels and free estrogen index in postmenopausal women

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Wnt signaling controls the fate of mesenchymal stem cells

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Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

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BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop

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THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

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High bone resorption in adult aging transgenic mice overexpressing cbfa1/runx2 in cells of the osteoblastic lineage

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

6 July 2018

Eukaryotic DNA Polymerases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

6 July 2018

Inhibin suppresses and activin stimulates osteoblastogenesis and osteoclastogenesis in murine bone marrow cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

6 July 2018

Minireview: the OPG/RANKL/RANK system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

6 July 2018

HMG1 and 2: architectural DNA-binding proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

6 July 2018

Significance analysis of microarrays applied to the ionizing radiation response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

6 July 2018

Tumor suppressors and oncogenes in cellular senescence.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

6 July 2018

Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

6 July 2018

Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

6 July 2018

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

6 July 2018

IGF2 derived from SH-SY5Y neuroblastoma cells induces the osteoclastogenesis of human monocytic precursors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

27 October 2018

The effect of bone morphogenetic protein-2, bone morphogenetic protein-7, parathyroid hormone, and platelet-derived growth factor on the proliferation and osteogenic differentiation of mesenchymal stem cells derived from osteoporotic bone.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

27 October 2018

Association between polymorphisms in Wnt signaling pathway genes and bone mineral density in postmenopausal Korean women.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

27 October 2018

The type 2 deiodinase Thr92Ala polymorphism is associated with increased bone turnover and decreased femoral neck bone mineral density.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

27 October 2018

Functional signature of human islet-derived precursor cells compared to bone marrow-derived mesenchymal stem cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

27 October 2018

HSD11B1 polymorphisms predicted bone mineral density and fracture risk in postmenopausal women without a clinically apparent hypercortisolemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

27 October 2018

Human primary osteocyte differentiation in a 3D culture system.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

27 October 2018

RANKL/OPG in primary cultures of osteoblasts from post-menopausal women. Differences between osteoporotic hip fractures and osteoarthritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

27 October 2018

Protein related to DAN and cerberus (PRDC) inhibits osteoblastic differentiation and its suppression promotes osteogenesis in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

27 October 2018

RHAMM is differentially expressed in the cell cycle and downregulated by the tumor suppressor p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

27 October 2018

Gene expression profile of the bone microenvironment in human fragility fracture bone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

27 October 2018

Coordinate expression of the human pregnancy-specific glycoprotein gene family during induced and replicative senescence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

27 October 2018

RAD51AP1 is a structure-specific DNA binding protein that stimulates joint molecule formation during RAD51-mediated homologous recombination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

27 October 2018

Osteoblast-targeted expression of Sfrp4 in mice results in low bone mass.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

27 October 2018

Endogenous Wnt signaling promotes proliferation and suppresses osteogenic differentiation in human adipose derived stromal cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

27 October 2018

Foxc1 integrates Fgf and Bmp signalling independently of twist or noggin during calvarial bone development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

27 October 2018

Altered epigenetic patterning leading to replicative senescence and reduced longevity. A role of a novel SNF2 factor, PASG.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

27 October 2018

Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

27 October 2018

Follistatin restricts bone morphogenetic protein (BMP)-2 action on the differentiation of osteoblasts in fetal rat mandibular cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

27 October 2018

Potentiating role of IGFBP-2 on IGF-II-stimulated alkaline phosphatase activity in differentiating osteoblasts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

27 October 2018

Circulating levels of osteoclast activating cytokines, interleukin-11 and transforming growth factor-beta2, as valuable biomarkers for the assessment of bone turnover in postmenopausal osteoporosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

27 October 2018

Osteopontin facilitates bone resorption, decreasing bone mineral crystallinity and content during calcium deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

27 October 2018

Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

27 October 2018

gp130-Mediated Signaling Is Necessary for Normal Osteoblastic Functionin Vivoandin Vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

9 December 2018

Skeletal Overexpression of Noggin Results in Osteopenia and Reduced Bone Formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454401

9 December 2018

TRAIL effect on osteoclast formation in physiological and pathological conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/23028809

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

VEGF enhancement of osteoclast survival and bone resorption involves VEGF receptor-2 signaling and beta3-integrin

1 reference

https://pubmed.ncbi.nlm.nih.gov/23028809

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A CD36-binding peptide from thrombospondin-1 can stimulate resorption by osteoclasts in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/23028809

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal osteogenesis in osteoporotic patients is reflected by altered mesenchymal stem cells dynamics

1 reference

https://pubmed.ncbi.nlm.nih.gov/23028809

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of Cdc25A contributes to cyclin E1-Cdk2 inhibition at senescence in human mammary epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23028809

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Circulating mesenchymal stem cells with abnormal osteogenic differentiation in patients with osteoporosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23028809

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetics of osteoporosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23028809

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostaglandin E2 stimulates osteoclast-like cell formation and bone-resorbing activity via osteoblasts: role of cAMP-dependent protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/23028809

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased bone formation and bone mass induced by sclerostin antibody is not affected by pretreatment or cotreatment with alendronate in osteopenic, ovariectomized rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/23028809

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0045142

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23028809%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

2012PLoSO...745142B

0 references

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23028809%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23028809%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

ResearchGate publication ID

0 references

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