Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling (Q34429013)

2 August 2017

title

Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling (English)

1 reference

2 August 2017

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Lin Luo

1

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Adam Alexander Wall

Adam A Wall

2

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Kaiwen W Chen

Kaiwen W Chen

7

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Simone M Schoenwaelder

Simone Schoenwaelder

6

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Brendan J. Jenkins

Brendan J Jenkins

9

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Brett M. Collins

Brett M Collins

12

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Kate Schroder

Kate Schroder

11

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Jennifer Stow

Jennifer L Stow

14

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Matthew J. Sweet

Matthew J Sweet

13

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Elizabeth L. Hartland

Elizabeth L Hartland

10

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Shaun P Jackson

Shaun Jackson

8

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author name string

Jeremy C Yeo

3

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2 August 2017

Nicholas D Condon

4

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2 August 2017

Suzanne J Norwood

5

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2 August 2017

publication date

15 July 2014

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2 August 2017

published in

Nature Communications

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2 August 2017

volume

5

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2 August 2017

page(s)

4407

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Intracellular trafficking and secretion of inflammatory cytokines

2 August 2017

cites work

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Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4

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The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes

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A network of Rab GTPases controls phagosome maturation and is modulated by Salmonella enterica serovar Typhimurium

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Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes

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Toll-like receptor signalling

21 January 2018

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The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.

21 January 2018

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CD14 controls the LPS-induced endocytosis of Toll-like receptor 4

21 January 2018

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TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta

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21 January 2018

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The TSC-mTOR signaling pathway regulates the innate inflammatory response

21 January 2018

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Defining the role of mTOR in cancer

21 January 2018

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Toll-like receptors in the pathogenesis of human disease

21 January 2018

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Membrane ruffles capture C3bi-opsonized particles in activated macrophages

21 January 2018

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Ruffles limit diffusion in the plasma membrane during macropinosome formation

21 January 2018

1 reference

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Dorsal ruffle microdomains potentiate Met receptor tyrosine kinase signaling and down-regulation

21 January 2018

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Foot and mouth: podosomes, invadopodia and circular dorsal ruffles

21 January 2018

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Characterization of the Rab8-specific membrane traffic route linked to protrusion formation

21 January 2018

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Phosphatidic acid is required for the constitutive ruffling and macropinocytosis of phagocytes

21 January 2018

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Sequential signaling in plasma-membrane domains during macropinosome formation in macrophages

21 January 2018

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Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains

21 January 2018

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Large scale screening for novel rab effectors reveals unexpected broad Rab binding specificity

21 January 2018

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Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

21 January 2018

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Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression.

21 January 2018

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Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils

21 January 2018

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p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma

21 January 2018

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Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma

21 January 2018

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A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1

21 January 2018

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Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

21 January 2018

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Shaping cups into phagosomes and macropinosomes

21 January 2018

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Coordination between RAB GTPase and phosphoinositide regulation and functions

21 January 2018

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Immune responses of macrophages and dendritic cells regulated by mTOR signalling.

21 January 2018

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Pathogen signatures activate a ubiquitination pathway that modulates the function of the metabolic checkpoint kinase mTOR.

21 January 2018

1 reference

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Rab8 GTPase as a regulator of cell shape

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5407

Coordination of Rab8 and Rab11 in primary ciliogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5407

Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5407

EPI64 interacts with Slp1/JFC1 to coordinate Rab8a and Arf6 membrane trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5407

Phosphatidylinositol-3-OH kinases are Rab5 effectors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5407

Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs)

21 January 2018

1 reference

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RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms

21 January 2018

1 reference

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Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function

21 January 2018

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The multiple facets of mTOR in immunity.

21 January 2018

1 reference

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Signal transducer and activator of transcription 3 (STAT3) mediates amino acid inhibition of insulin signaling through serine 727 phosphorylation

21 January 2018

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PI3Kgamma inhibition: towards an 'aspirin of the 21st century'?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5407

Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5407

Inhibition of phosphoinositide 3-kinase γ attenuates inflammation, obesity, and cardiovascular risk factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5407

The phosphoinositide phosphatase SopB manipulates membrane surface charge and trafficking of the Salmonella-containing vacuole

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5407

PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5407

Vps29 has a phosphoesterase fold that acts as a protein interaction scaffold for retromer assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5407

Localization and post-Golgi trafficking of tumor necrosis factor-alpha in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5407

Enhanced EGFP-chromophore-assisted laser inactivation using deficient cells rescued with functional EGFP-fusion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5407

A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5407

Production, concentration and titration of pseudotyped HIV-1-based lentiviral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5407

The t-SNARE syntaxin 4 is regulated during macrophage activation to function in membrane traffic and cytokine secretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5407

Syntaxin 6 and Vti1b form a novel SNARE complex, which is up-regulated in activated macrophages to facilitate exocytosis of tumor necrosis Factor-alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5407

Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5407

Single-step protease cleavage elution for identification of protein-protein interactions from GST pull-down and mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5407

Kinetics of interaction of Rab5 and Rab7 with nucleotides and magnesium ions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5407

Erratum: Corrigendum: A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5407

Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5407

7 January 2021

Survival of mononuclear phagocytes depends on a lineage-specific growth factor that the differentiated cells selectively destroy

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5407

7 January 2021

Regulation of bone-marrow macrophage proliferation

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5407

7 January 2021

High-throughput quantification of early stages of phagocytosis

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS5407

7 January 2021

Identifiers

DOI

10.1038/NCOMMS5407

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Dimensions Publication ID

2 August 2017

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1042488076

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1 reference