Insight into the role of mTOR and metabolism in T cells reveals new potential approaches to preventing graft rejection (Q34437449)

2 August 2017

title

Insight into the role of mTOR and metabolism in T cells reveals new potential approaches to preventing graft rejection (English)

1 reference

2 August 2017

Ying-Chun Lo

1

1 reference

2 August 2017

Chen-Fang Lee

series ordinal

2

1 reference

2 August 2017

Jonathan D Powell

series ordinal

3

1 reference

2 August 2017

publication date

1 August 2014

1 reference

Current opinion in organ transplantation

2 August 2017

published in

1 reference

2 August 2017

volume

19

1 reference

2 August 2017

issue

4

1 reference

2 August 2017

page(s)

363-371

1 reference

The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex.

2 August 2017

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6 July 2018

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FOXO transcription factors throughout T cell biology

6 July 2018

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Progesterone suppresses the mTOR pathway and promotes generation of induced regulatory T cells with increased stability

6 July 2018

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The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis

6 July 2018

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6 July 2018

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6 July 2018

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The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

6 July 2018

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6 July 2018

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6 July 2018

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Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways

6 July 2018

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HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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mTOR signalling and metabolic regulation of T cell differentiation

6 July 2018

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Activation of a metabolic gene regulatory network downstream of mTOR complex 1

6 July 2018

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Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways

6 July 2018

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Glutamine uptake and metabolism are coordinately regulated by ERK/MAPK during T lymphocyte activation

6 July 2018

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Phosphoinositide 3-kinase and the mammalian target of rapamycin pathways control T cell migration

6 July 2018

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PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

6 July 2018

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Allogeneic hematopoietic stem-cell transplantation for sickle cell disease

6 July 2018

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Anergic T cells are metabolically anergic

6 July 2018

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6 July 2018

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6 July 2018

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Infectious tolerance via the consumption of essential amino acids and mTOR signaling

6 July 2018

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Differential responses of human regulatory T cells (Treg) and effector T cells to rapamycin

6 July 2018

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mTOR regulates memory CD8 T-cell differentiation

6 July 2018

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The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment

6 July 2018

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Bidirectional transport of amino acids regulates mTOR and autophagy

6 July 2018

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Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor.

6 July 2018

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mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

6 July 2018

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SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding

6 July 2018

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Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

6 July 2018

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Dissecting the mechanism of T-cell anergy with immunophilin ligands

6 July 2018

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6 July 2018

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Kruppel-like factor 2 regulates thymocyte and T-cell migration

6 July 2018

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Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes.

6 July 2018

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

6 July 2018

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6 July 2018

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Fuel feeds function: energy metabolism and the T-cell response

6 July 2018

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6 July 2018

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Cyclin D1 and c-myc internal ribosome entry site (IRES)-dependent translation is regulated by AKT activity and enhanced by rapamycin through a p38 MAPK- and ERK-dependent pathway.

6 July 2018

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6 July 2018

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On the Origin of Cancer Cells

6 July 2018

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Rheb promotes cell growth as a component of the insulin/TOR signalling network

6 July 2018

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Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability

6 July 2018

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Inhibition of amino acid-mTOR signaling by a leucine derivative induces G1 arrest in Jurkat cells

6 July 2018

1 reference

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The CD28 signaling pathway regulates glucose metabolism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4216568

Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis.

6 July 2018

1 reference

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Regulation of cellular growth by the Drosophila target of rapamycin dTOR

6 July 2018

1 reference

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Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins

6 July 2018

1 reference

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Rheb interacts with Raf-1 kinase and may function to integrate growth factor- and protein kinase A-dependent signals

6 July 2018

1 reference

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TOR controls translation initiation and early G1 progression in yeast

6 July 2018

1 reference

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Immunopharmacology of rapamycin

6 July 2018

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rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein

6 July 2018

1 reference

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Comparison of the effects of FK-506, cyclosporin A and rapamycin on IL-2 production

6 July 2018

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Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

6 July 2018

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Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle

6 July 2018

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The transcription factor Foxo1 controls central-memory CD8+ T cell responses to infection

6 July 2018

1 reference

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Association between calcineurin inhibitor treatment and peripheral nerve dysfunction in renal transplant recipients

27 October 2018

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27 October 2018

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ER stress inhibits mTORC2 and Akt signaling through GSK-3β-mediated phosphorylation of rictor.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4216568

Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4216568

The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4216568

FOXO1 regulates L-Selectin and a network of human T cell homing molecules downstream of phosphatidylinositol 3-kinase

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4216568

Cutting edge: Foxp3-mediated induction of pim 2 allows human T regulatory cells to preferentially expand in rapamycin

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4216568

AMP-activated protein kinase regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4216568

Sequence motifs in IL-4R alpha mediating cell-cycle progression of primary lymphocytes.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4216568

5-aminoimidazole-4-carboxamide ribonucleoside: a novel immunomodulator with therapeutic efficacy in experimental autoimmune encephalomyelitis.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4216568

Intracellular sensing of amino acids in Xenopus laevis oocytes stimulates p70 S6 kinase in a target of rapamycin-dependent manner

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4216568

Steroids and risk of upper gastrointestinal complications

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4216568

Mammalian target of rapamycin: immunosuppressive drugs uncover a novel pathway of cytokine receptor signaling

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4216568

Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4216568

Transplantation 50 years later--progress, challenges, and promises

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24991977

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1097/MOT.0000000000000098

1 reference

2 August 2017

1 reference

2 August 2017

1 reference