The basic helix-loop-helix transcription factor Nex-1/Math-2 promotes neuronal survival of PC12 cells by modulating the dynamic expression of anti-apoptotic and cell cycle regulators. (Q34474341)

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English	The basic helix-loop-helix transcription factor Nex-1/Math-2 promotes neuronal survival of PC12 cells by modulating the dynamic expression of anti-apoptotic and cell cycle regulators.	scientific article

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7 January 2020

The basic helix-loop-helix transcription factor Nex-1/Math-2 promotes neuronal survival of PC12 cells by modulating the dynamic expression of anti-apoptotic and cell cycle regulators (English)

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7 January 2020

apoptotic process

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Anne Chiaramello

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Martine Uittenbogaard

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1 February 2005

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7 January 2020

Journal of Neurochemistry

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92

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3

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585-596

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7 January 2020

Basic helix-loop-helix proteins bind to TrkB and p21(Cip1) promoters linking differentiation and cell cycle arrest in neuroblastoma cells.

1 reference

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Bcl-xL/Bcl-2 coordinately regulates apoptosis, cell cycle arrest and cell cycle entry

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The basic helix-loop-helix differentiation factor Nex1/MATH-2 functions as a key activator of the GAP-43 gene

1 reference

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Constitutive overexpression of the basic helix-loop-helix Nex1/MATH-2 transcription factor promotes neuronal differentiation of PC12 cells and neurite regeneration.

1 reference

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Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems

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Identification and characterization of nuclear factor kappaB binding sites in the murine bcl-x promoter.

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Phosphorylation of the PTEN tail regulates protein stability and function

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Bcl-2 retards cell cycle entry through p27(Kip1), pRB relative p130, and altered E2F regulation

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The relationship between neuronal survival and regeneration.

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6 July 2018

Neuronal basic helix-loop-helix proteins (NEX and BETA2/Neuro D) regulate terminal granule cell differentiation in the hippocampus

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6 July 2018

CREB couples neurotrophin signals to survival messages

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The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling

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Generation of neurons by transient expression of neural bHLH proteins in mammalian cells

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Cellular survival: a play in three Akts

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p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB

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Transcriptional analysis of human survivin gene expression

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6 July 2018

IAP family proteins--suppressors of apoptosis

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6 July 2018

Control of apoptosis and mitotic spindle checkpoint by survivin

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1411982

6 July 2018

The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases

1 reference

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6 July 2018

The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry

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6 July 2018

X-linked IAP is a direct inhibitor of cell-death proteases

1 reference

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6 July 2018

Cyclin D1 is an essential mediator of apoptotic neuronal cell death.

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Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

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Cell death during development of the nervous system

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Nerve growth factor prevents the death and stimulates the neuronal differentiation of clonal PC12 pheochromocytoma cells in serum-free medium

1 reference

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6 July 2018

NEX-1: a novel brain-specific helix-loop-helix protein with autoregulation and sustained expression in mature cortical neurons.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02886.X

21 January 2018

Acute ablation of survivin uncovers p53-dependent mitotic checkpoint functions and control of mitochondrial apoptosis.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02886.X

21 January 2018

A population of PC12 cells that is initiating apoptosis can be rescued by nerve growth factor.

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21 January 2018

Differential expression of bcl-w and bcl-x messenger RNA in the developing and adult rat nervous system.

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21 January 2018

Need for caspase-2 in apoptosis of growth-factor-deprived PC12 cells.

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21 January 2018

NeuroD2 is necessary for development and survival of central nervous system neurons.

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21 January 2018

Ordering the cell death pathway. Differential effects of BCL2, an interleukin-1-converting enzyme family protease inhibitor, and other survival agents on JNK activation in serum/nerve growth factor-deprived PC12 cells

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21 January 2018

Expression profiling upon Nex1/MATH-2-mediated neuritogenesis in PC12 cells and its implication in regeneration

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https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02886.X

21 January 2018

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1 reference

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21 January 2018

hCDC47, a Human Member of the MCM Family

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02886.X

21 January 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1411982

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1 reference

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27 October 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1411982

27 October 2018

G1/S cell cycle blockers and inhibitors of cyclin-dependent kinases suppress camptothecin-induced neuronal apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15659228

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nedd2 is required for apoptosis after trophic factor withdrawal, but not superoxide dismutase (SOD1) downregulation, in sympathetic neurons and PC12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15659228

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin dependent kinase inhibitors and dominant negative cyclin dependent kinase 4 and 6 promote survival of NGF-deprived sympathetic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/15659228

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-apoptosis gene, survivin, and prognosis of neuroblastoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/15659228

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-2 (Nedd-2) processing and death of trophic factor-deprived PC12 cells and sympathetic neurons occur independently of caspase-3 (CPP32)-like activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15659228

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nerve growth factor determines survival and death of PC12 cells by regulation of the bcl-x, bax, and caspase-3 genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15659228

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation-dependent Akt cleavage in neural cell in vitro reconstitution of apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15659228

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

xIAP induces cell-cycle arrest and activates nuclear factor-kappaB : new survival pathways disabled by caspase-mediated cleavage during apoptosis of human endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15659228

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/15659228

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2 affects survival but not neuronal differentiation of PC12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15659228

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15659228

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell cycle blockers mimosine, ciclopirox, and deferoxamine prevent the death of PC12 cells and postmitotic sympathetic neurons after removal of trophic support

1 reference

https://pubmed.ncbi.nlm.nih.gov/15659228

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2 has a cell cycle inhibitory function separable from its enhancement of cell survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/15659228

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of CPP32-like activity in PC12 cells by withdrawal of trophic support. Dissociation from apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15659228

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1471-4159.2004.02886.X

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15659228%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

1 reference

Europe PubMed Central

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7 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15659228%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

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