A critical role for Mnt in Myc-driven T-cell proliferation and oncogenesis (Q34476361)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23150551%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

title

A critical role for Mnt in Myc-driven T-cell proliferation and oncogenesis (English)

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17 February 2020

1

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17 February 2020

author name string

Sara Ota

2

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17 February 2020

Zi-Qiang Zhou

3

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17 February 2020

Colin J Daniel

4

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17 February 2020

Rosalie C Sears

5

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17 February 2020

Peter J Hurlin

6

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17 February 2020

language of work or name

English

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publication date

12 November 2012

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Proceedings of the National Academy of Sciences of the United States of America

17 February 2020

published in

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17 February 2020

volume

109

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17 February 2020

issue

48

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17 February 2020

page(s)

19685-19690

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Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC.

17 February 2020

cites work

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The action mechanism of the Myc inhibitor termed Omomyc may give clues on how to target Myc for cancer therapy

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Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

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OX40 engagement stabilizes Mxd4 and Mnt protein levels in antigen-stimulated T cells leading to an increase in cell survival

6 July 2018

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Phosphorylation regulates c-Myc's oncogenic activity in the mammary gland.

6 July 2018

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The metabolic life and times of a T-cell

6 July 2018

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MYC in oncogenesis and as a target for cancer therapies

6 July 2018

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6 July 2018

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MYC as a regulator of ribosome biogenesis and protein synthesis

6 July 2018

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Coupling of the cell cycle and apoptotic machineries in developing T cells

6 July 2018

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The ups and downs of Myc biology

6 July 2018

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MYC-induced cancer cell energy metabolism and therapeutic opportunities

6 July 2018

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MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT.

6 July 2018

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c-Myc activates multiple metabolic networks to generate substrates for cell-cycle entry

6 July 2018

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Distinct thresholds govern Myc's biological output in vivo

6 July 2018

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Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

6 July 2018

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6 July 2018

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Drosophila growth and development in the absence of dMyc and dMnt

6 July 2018

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Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species

6 July 2018

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HIF-dependent antitumorigenic effect of antioxidants in vivo

6 July 2018

1 reference

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Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway

6 July 2018

1 reference

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Conditional transgenic models define how MYC initiates and maintains tumorigenesis

6 July 2018

1 reference

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c-Myc mediates pre-TCR-induced proliferation but not developmental progression

6 July 2018

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Mnt-deficient mammary glands exhibit impaired involution and tumors with characteristics of myc overexpression.

6 July 2018

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Inflammatory disease and lymphomagenesis caused by deletion of the Myc antagonist Mnt in T cells

6 July 2018

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6 July 2018

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Fuel feeds function: energy metabolism and the T-cell response

6 July 2018

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Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants

6 July 2018

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The transcriptional repressor dMnt is a regulator of growth in Drosophila melanogaster

6 July 2018

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Mnt-Max to Myc-Max complex switching regulates cell cycle entry

6 July 2018

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Intrinsic tumour suppression

6 July 2018

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Mnt loss triggers Myc transcription targets, proliferation, apoptosis, and transformation

6 July 2018

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Myc pathways provoking cell suicide and cancer

6 July 2018

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Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines

6 July 2018

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Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis

6 July 2018

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T cell apoptosis and reactive oxygen species

6 July 2018

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Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression.

6 July 2018

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Antigen-presenting dendritic cells provide the reducing extracellular microenvironment required for T lymphocyte activation

6 July 2018

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Analysis of C-MYC function in normal cells via conditional gene-targeted mutation

6 July 2018

1 reference

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The Myc/Max/Mad network and the transcriptional control of cell behavior

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3511755

The c-Myc transactivation domain is a direct modulator of apoptotic versus proliferative signals

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3511755

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3511755

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3511755

Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3511755

Recombinant interleukin 2 regulates levels of c-myc mRNA in a cloned murine T lymphocyte

6 July 2018

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Cooperative interaction between c-myc and bcl-2 proto-oncogenes

6 July 2018

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Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites.

6 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1206406109

Defining the specific physiological requirements for c-Myc in T cell development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1206406109

Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1206406109

Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production

21 January 2018

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Revving the engine: signal transduction fuels T cell activation.

21 January 2018

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CTLA4-CD80/CD86 interactions on primary mouse CD4+ T cells integrate signal-strength information to modulate activation with Concanavalin A

27 October 2018

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Mnt: master regulator of the Max network

27 October 2018

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Conditional expression and oncogenicity of c-myc linked to a CD2 gene dominant control region

27 October 2018

1 reference

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Phosphorylation sites mapping in the N-terminal domain of c-myc modulate its transforming potential.

27 October 2018

1 reference

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T-cell apoptosis detected in situ during positive and negative selection in the thymus

27 October 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1206406109

c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability

21 January 2018

1 reference

12 December 2020

c-Myc hot spot mutations in lymphomas result in inefficient ubiquitination and decreased proteasome-mediated turnover

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12 December 2020

Reversible activation of c-Myc in thymocytes enhances positive selection and induces proliferation and apoptosis in vitro

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12 December 2020

Modulation of T-cell functions. I. Effect of 2-mercaptoethanol and macrophages on T-cell proliferation

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12 December 2020

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

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12 December 2020

N-acetylcysteine enhances T cell functions and T cell growth in culture

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12 December 2020

Mitochondrial perturbations define lymphocytes undergoing apoptotic depletion in vivo

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12 December 2020

Identifiers

DOI

10.1073/PNAS.1206406109

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23150551%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23150551%20AND%20SRC:MED&resulttype=core&format=json

17 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23150551%20AND%20SRC:MED&resulttype=core&format=json