MDM2 overexpression generates a skin phenotype in both wild type and p53 null mice. (Q42468494)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10050879%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

title

MDM2 overexpression generates a skin phenotype in both wild type and p53 null mice (English)

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11 November 2019

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5

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11 November 2019

author name string

M Alkhalaf

1

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11 November 2019

G Ganguli

2

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11 November 2019

N Messaddeq

3

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11 November 2019

M Le Meur

4

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11 November 2019

language of work or name

English

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publication date

1 February 1999

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11 November 2019

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11 November 2019

volume

18

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11 November 2019

issue

7

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11 November 2019

page(s)

1419-1434

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1202448

11 November 2019

exact match

0 references

cites work

Targeted expression of the E6 and E7 oncogenes of human papillomavirus type 16 in the epidermis of transgenic mice elicits generalized epidermal hyperplasia involving autocrine factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

The genetics of ichthyosis: a primer for epidemiologists

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Overexpression of insulin-like growth factor-1 induces hyperplasia, dermal abnormalities, and spontaneous tumor formation in transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Transgenic mice and squamous multistage skin carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Multiple patterns of MDM-2 deregulation in human leukemias: implications in leukemogenesis and prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Regulation of gene expression in developing epidermal epithelia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Tissue- and stratum-specific expression of the human involucrin promoter in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

MDM-2 protein is expressed in different layers of normal human skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

The genetics of human skin diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Amplification of MDM2 inhibits MyoD-mediated myogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Transgenic mice expressing a mutant keratin 10 gene reveal the likely genetic basis for epidermolytic hyperkeratosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

The variability in activity of the universally expressed human cytomegalovirus immediate early gene 1 enhancer/promoter in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Physical and functional interaction between wild-type p53 and mdm2 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

21 January 2018

The mdm2 proto-oncogene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Tumor suppressors: a developing role for p53?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

p53; from inductive signal to cellular effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Tumor spectrum analysis in p53-mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

E2F as a regulator of keratinocyte proliferation: implications for skin tumor development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Unusual cell specific expression of a major human cytomegalovirus immediate early gene promoter-lacZ hybrid gene in transgenic mouse embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

MDM2--arbiter of p53's destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

The MDM2 C-terminal region binds to TAFII250 and is required for MDM2 regulation of the cyclin A promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

p53, the cellular gatekeeper for growth and division

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Analysis of p53 and mdm-2 expression in 18 patients with Sézary syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Mdm-2: "big brother" of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

The organization and expression of the mdm2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

p53 and tumour viruses: catching the guardian off-guard

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Mdm2: keeping p53 under control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Expression of cyclin D1 in epithelial tissues of transgenic mice results in epidermal hyperproliferation and severe thymic hyperplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Delays in malignant tumor development in transgenic mice by forced epidermal keratin 10 expression in mouse skin carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

The cytomegalovirus enhancer: a pan-active control element in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Human papillomavirus type 16 E6 and E7 oncogenes abrogate radiation-induced DNA damage responses in vivo through p53-dependent and p53-independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Repression of p53-mediated transcription by MDM2: a dual mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Expression of a p53 mutant in the epidermis of transgenic mice accelerates chemical carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

p53 tumor-suppressor gene: clues to molecular carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Ichthyosis: mechanisms of disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Interaction between the retinoblastoma protein and the oncoprotein MDM2

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1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Transgenic Mice Expressing IFN-γ in the Epidermis Have Eczema, Hair Hypopigmentation, and Hair Loss

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1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

Involvement of p53 in cell differentiation and development

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1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

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Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic mice

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

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The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

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1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

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1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

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1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

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1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

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1 reference

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1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

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1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202448

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Identifiers

DOI

10.1038/SJ.ONC.1202448

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10050879%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

11 November 2019

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