The tuberin/mTOR pathway promotes apoptosis of tubular epithelial cells in diabetes (Q34534870)

2 August 2017

title

The tuberin/mTOR pathway promotes apoptosis of tubular epithelial cells in diabetes (English)

1 reference

2 August 2017

1 reference

Chakradhar Velagapudi

1

1 reference

2 August 2017

Basant S Bhandari

2

1 reference

2 August 2017

Sherry Abboud-Werner

3

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2 August 2017

Simona Simone

4

1 reference

2 August 2017

Hanna E Abboud

5

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2 August 2017

Samy L Habib

6

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2 August 2017

publication date

1 February 2011

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Journal of the American Society of Nephrology

2 August 2017

published in

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2 August 2017

volume

22

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2 August 2017

issue

2

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2 August 2017

page(s)

262-273

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Attenuated mTOR signaling and enhanced autophagy in adipocytes from obese patients with type 2 diabetes

2 August 2017

cites work

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Mechanism of oxidative DNA damage in diabetes: tuberin inactivation and downregulation of DNA repair enzyme 8-oxo-7,8-dihydro-2'-deoxyguanosine-DNA glycosylase

7 July 2018

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Tuberin haploinsufficiency is associated with the loss of OGG1 in rat kidney tumors

7 July 2018

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Overexpression of angiotensinogen increases tubular apoptosis in diabetes

7 July 2018

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Tsc2 expression increases the susceptibility of renal tumor cells to apoptosis

7 July 2018

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The pathobiology of diabetic complications: a unifying mechanism

7 July 2018

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Caspase-dependent regulation and subcellular redistribution of the transcriptional modulator YY1 during apoptosis

7 July 2018

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Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells

7 July 2018

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Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

7 July 2018

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Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

7 July 2018

1 reference

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Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

7 July 2018

1 reference

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Rheb promotes cell growth as a component of the insulin/TOR signalling network

7 July 2018

1 reference

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High glucose-induced oxidative stress causes apoptosis in proximal tubular epithelial cells and is mediated by multiple caspases

7 July 2018

1 reference

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Taurine prevents apoptosis induced by high ambient glucose in human tubule renal cells.

7 July 2018

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A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling

7 July 2018

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The Bcl2 family: regulators of the cellular life-or-death switch

7 July 2018

1 reference

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Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation

7 July 2018

1 reference

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A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells

7 July 2018

1 reference

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Mammalian caspases: structure, activation, substrates, and functions during apoptosis

7 July 2018

1 reference

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Ribosomal S6 kinase signaling and the control of translation

7 July 2018

1 reference

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Cellular responses to DNA damage in the absence of Poly(ADP-ribose) polymerase

7 July 2018

1 reference

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Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

7 July 2018

1 reference

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Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

7 July 2018

1 reference

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Poly(ADP-ribose) in the cellular response to DNA damage

7 July 2018

1 reference

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

7 July 2018

1 reference

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Rapamycin induces autophagy and exacerbates metabolism associated complications in a mouse model of type 1 diabetes.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3029899

Tuberin regulates the DNA repair enzyme OGG1.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3029899

Tuberin activates the proapoptotic molecule BAD.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3029899

Apoptosis induced by oxalate in human renal tubular epithelial HK-2 cells

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3029899

Oxidative stress mediates apoptotic changes induced by hyperglycemia in human tubular kidney cells.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3029899

Reduced constitutive 8-oxoguanine-DNA glycosylase expression and impaired induction following oxidative DNA damage in the tuberin deficient Eker rat.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3029899

Damaged microtubules can inactivate BCL-2 by means of the mTOR kinase.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3029899

High glucose inhibits renal proximal tubule cell proliferation and involves PKC, oxidative stress, and TGF-beta 1.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3029899

27 October 2018

Identifiers

DOI

10.1681/ASN.2010040352

1 reference

2 August 2017

1 reference

2 August 2017

1 reference