Many ways to telomere dysfunction: in vivo studies using mouse models (Q34535647)

2 August 2017

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title

Many ways to telomere dysfunction: in vivo studies using mouse models (English)

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2 August 2017

María A Blasco

2

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author name string

Fermín A Goytisolo

series ordinal

1

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PubMed ID

11850783

2 August 2017

language of work or name

English

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publication date

1 January 2002

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2 August 2017

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2 August 2017

21

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2 August 2017

584-591

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2 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1205085

2 August 2017

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cites work

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

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DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes

21 January 2018

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

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Atm-deficient mice: a paradigm of ataxia telangiectasia

21 January 2018

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Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways.

21 January 2018

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Pot1, the putative telomere end-binding protein in fission yeast and humans

21 January 2018

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Ku binds telomeric DNA in vitro

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Telomeric localization of TRF2, a novel human telobox protein

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Telomere states and cell fates

21 January 2018

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Functional characterization and developmental regulation of mouse telomerase RNA.

21 January 2018

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Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

21 January 2018

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Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Two survivor pathways that allow growth in the absence of telomerase are generated by distinct telomere recombination events

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

21 January 2018

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A human telomeric protein

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Mammalian telomeres and telomerase

21 January 2018

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DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

21 January 2018

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Telomere maintenance by recombination in human cells.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang.

21 January 2018

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Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals

21 January 2018

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Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Telomeres do D-loop-T-loop

21 January 2018

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Mammalian telomeres end in a large duplex loop

21 January 2018

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Aging. What makes us tick?

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Inhibition of telomerase limits the growth of human cancer cells.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Telomeres shorten during ageing of human fibroblasts

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

G-strand overhangs on telomeres in telomerase-deficient mouse cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Wild-derived inbred mouse strains have short telomeres

21 January 2018

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Impaired germinal center reaction in mice with short telomeres.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Telomere shortening in mTR-/- embryos is associated with failure to close the neural tube

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Disease states associated with telomerase deficiency appear earlier in mice with short telomeres

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Ku is associated with the telomere in mammals

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Ku acts in a unique way at the mammalian telomere to prevent end joining

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

TIN2, a new regulator of telomere length in human cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Essential role of mouse telomerase in highly proliferative organs

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Telomere dysfunction alters the chemotherapeutic profile of transformed cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Identification of human Rap1: implications for telomere evolution

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

An alternative pathway for yeast telomere maintenance rescues est1- senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

The terminal DNA structure of mammalian chromosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Circular chromosome formation in a fission yeast mutant defective in two ATM homologues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Severe growth defect in mouse cells lacking the telomerase RNA component.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

The telomerase reverse transcriptase: components and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Telomere maintenance is dependent on activities required for end repair of double-strand breaks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

In vitro reconstitution of the end replication problem

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Chromosome end associations, telomeres and telomerase activity in ataxia telangiectasia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Defects in mismatch repair promote telomerase-independent proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Telomere dysfunction and evolution of intestinal carcinoma in mice and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Normal telomere length and chromosomal end capping in poly(ADP-ribose) polymerase-deficient mice and primary cells despite increased chromosomal instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc-/- mice with short telomeres.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Role of the INK4a locus in tumor suppression and cell mortality.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

A survey of telomerase activity in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

The DNA-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Tankyrase, a poly(ADP-ribose) polymerase at human telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Control of human telomere length by TRF1 and TRF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Interaction of human Ku70 with TRF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Control of telomere length by the human telomeric protein TRF1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

TRF2 Protects Human Telomeres from End-to-End Fusions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Deletion of Ku86 causes early onset of senescence in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Normal human chromosomes have long G-rich telomeric overhangs at one end

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Nuclear structure in normal and Bloom syndrome cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Telomeres: has cancer's Achilles' heel been exposed?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

CELL BIOLOGY: Enhanced: Telomere Capping--One Strand Fits All

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Accelerated telomere shortening in ataxia telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

Tankyrase promotes telomere elongation in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

21 January 2018

Telomeres and telomerase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

7 January 2021

Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

7 January 2021

Telomere elongation in immortal human cells without detectable telomerase activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

7 January 2021

Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

7 January 2021

Yeast Ku as a regulator of chromosomal DNA end structure

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

7 January 2021

Elongated Telomeres inscidMice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

7 January 2021

SGS1 is required for telomere elongation in the absence of telomerase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

7 January 2021

Presence of telomeric G-strand tails in the telomerase catalytic subunit TERT knockout mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

7 January 2021

Influence of ATM function on telomere metabolism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

7 January 2021

Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

7 January 2021

Different means to common ends

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

7 January 2021

Molecular biology. DNA ends ReQ-uire attention

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

7 January 2021

Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205085

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205085

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/756qwpo5qza5fi2gcwsmat7s3u

30 July 2022

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Dimensions Publication ID

1031977888

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Fatcat ID

release_756qwpo5qza5fi2gcwsmat7s3u

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Fatcat

https://api.fatcat.wiki/v0/release/756qwpo5qza5fi2gcwsmat7s3u

30 July 2022

mapped directly with Wikidata item

1 reference

https://api.fatcat.wiki/v0/release/756qwpo5qza5fi2gcwsmat7s3u

30 July 2022