Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: a novel mechanism of action (Q34556705)

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English	Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: a novel mechanism of action	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

3 August 2017

Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: a novel mechanism of action (English)

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Europe PubMed Central

PubMed publication ID

3 August 2017

D Allan Butterfield

9

object named as

D Allan Butterfield

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3 August 2017

author name string

Eugenio Barone

1

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3 August 2017

Giovanna Cenini

2

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3 August 2017

Fabio Di Domenico

3

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Europe PubMed Central

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3 August 2017

Sarah Martin

4

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Europe PubMed Central

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3 August 2017

Rukhsana Sultana

5

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3 August 2017

Cesare Mancuso

6

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3 August 2017

Michael Paul Murphy

7

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3 August 2017

Elizabeth Head

8

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3 August 2017

publication date

27 December 2010

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3 August 2017

Pharmacological Research

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3 August 2017

63

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3 August 2017

3

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Europe PubMed Central

PubMed publication ID

3 August 2017

172-180

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Statins for the treatment of dementia

1 reference

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25-hydroxycholesterol provokes oligodendrocyte cell line apoptosis and stimulates the secreted phospholipase A2 type IIA via LXR beta and PXR.

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The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches.

1 reference

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Brain cholesterol metabolism and neurologic disease

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Pleiotropic effects of statin therapy: molecular mechanisms and clinical results.

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Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity

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Roles of amyloid beta-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment

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Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease

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Oxysterols, cholesterol homeostasis, and Alzheimer disease

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Alzheimer's disease and cholesterol: the fat connection

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Mitochondrial dysfunction, free radical generation and cellular stress response in neurodegenerative disorders

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Oxidative stress and neurodegeneration: where are we now?

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7 July 2018

Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: insights into the development of Alzheimer's disease

1 reference

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7 July 2018

HPLC assay and pharmacokinetic study of atorvastatin in beagle dogs after oral administration of atorvastatin self-microemulsifying drug delivery system

1 reference

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Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment

1 reference

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Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins

1 reference

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7 July 2018

Pleiotropic effects of statins

1 reference

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7 July 2018

Mild cognitive impairment clinical trials

1 reference

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7 July 2018

Cholesterol homeostasis and function in neurons of the central nervous system

1 reference

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7 July 2018

Lipid peroxidation and protein oxidation in Alzheimer's disease brain: potential causes and consequences involving amyloid beta-peptide-associated free radical oxidative stress

1 reference

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7 July 2018

A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease

1 reference

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7 July 2018

The -48 C/T polymorphism in the presenilin 1 promoter is associated with an increased risk of developing Alzheimer's disease and an increased Abeta load in brain.

1 reference

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7 July 2018

Alzheimer's disease: genes, proteins, and therapy

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7 July 2018

Acrolein is increased in Alzheimer's disease brain and is toxic to primary hippocampal cultures

1 reference

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7 July 2018

Statins and the risk of dementia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3034810

7 July 2018

Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

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7 July 2018

Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

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7 July 2018

Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity

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7 July 2018

Region-specific age at onset of beta-amyloid in dogs

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Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

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Hydrophilicity/lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors

1 reference

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7 July 2018

beta-Amyloid-associated free radical oxidative stress and neurotoxicity: implications for Alzheimer's disease

1 reference

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7 July 2018

Oxidative stress hypothesis in Alzheimer's disease

1 reference

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7 July 2018

Atorvastatin. A review of its pharmacology and therapeutic potential in the management of hyperlipidaemias

1 reference

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7 July 2018

A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide.

1 reference

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7 July 2018

Subchronic toxicity of atorvastatin, a hydroxymethylglutaryl-coenzyme A reductase inhibitor, in beagle dogs.

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In vivo and in vitro blood-brain barrier transport of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors

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7 July 2018

Advanced Maillard reaction end products, free radicals, and protein oxidation in Alzheimer's disease

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7 July 2018

Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis

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7 July 2018

Changes in cognition and amyloid-β processing with long term cholesterol reduction using atorvastatin in aged dogs.

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27 October 2018

Comparison of effects of simvastatin versus atorvastatin on oxidative stress in patients with coronary heart disease.

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27 October 2018

Atorvastatin increases blood ratios of vitamin E/low-density lipoprotein cholesterol and coenzyme Q10/low-density lipoprotein cholesterol in hypercholesterolemic patients

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27 October 2018

In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid beta-peptide of APP.

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27 October 2018

Pleiotropic effects of atorvastatin on monocytes in atherosclerotic patients

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27 October 2018

The Atorvastatin/Donepezil in Alzheimer's Disease Study (LEADe): design and baseline characteristics

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27 October 2018

Biphasic effects of atorvastatin on inflammation.

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27 October 2018

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27 October 2018

Prevention of 7-ketocholesterol-induced mitochondrial damage and cell death by calmodulin inhibition.

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27 October 2018

Nitrosative stress, cellular stress response, and thiol homeostasis in patients with Alzheimer's disease.

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27 October 2018

Circulating cholesterol levels, apolipoprotein E genotype and dementia severity influence the benefit of atorvastatin treatment in Alzheimer's disease: results of the Alzheimer's Disease Cholesterol-Lowering Treatment (ADCLT) trial.

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Neuropathologic outcome of mild cognitive impairment following progression to clinical dementia.

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1 reference

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1 reference

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Oxidative stress precedes fibrillar deposition of Alzheimer's disease amyloid beta-peptide (1-42) in a transgenic Caenorhabditis elegans model.

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Statin therapy for Alzheimer's disease: will it work?

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Causes and consequences of oxidative stress in Alzheimer's disease.

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27 October 2018

Ultrastructural analyses of beta-amyloid in the aged dog brain: neuronal beta-amyloid is localized to the plasma membrane.

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27 October 2018

Ultrastructural evidence of fibrillar beta-amyloid associated with neuronal membranes in behaviorally characterized aged dog brains.

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27 October 2018

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27 October 2018

Brain Regional Correspondence Between Alzheimer's Disease Histopathology and Biomarkers of Protein Oxidation

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Clusterin (apoJ) Alters the Aggregation of Amyloid β-Peptide (Aβ1-42) and Forms Slowly Sedimenting Aβ Complexes That Cause Oxidative Stress

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Effects of atorvastatin therapy on hypercholesterolemic rabbits with respect to oxidative stress, nitric oxide pathway and homocysteine

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Multiple-dose pharmacokinetics, pharmacodynamics, and safety of atorvastatin, an inhibitor of HMG-CoA reductase, in healthy subjects

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based on heuristic

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Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates

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https://pubmed.ncbi.nlm.nih.gov/21193043

12 December 2020

based on heuristic

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Increased plasma levels of oxysterols, in vivo markers of oxidative stress, in patients with familial combined hyperlipidemia: Reduction during atorvastatin and fenofibrate therapy

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https://pubmed.ncbi.nlm.nih.gov/21193043

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gas chromatography-mass spectrometry-based simultaneous quantitative analytical method for urinary oxysterols and bile acids in rats

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https://pubmed.ncbi.nlm.nih.gov/21193043

12 December 2020

based on heuristic

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Pharmacodynamics and pharmacokinetic-pharmacodynamic relationships of atorvastatin, an HMG-CoA reductase inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/21193043

12 December 2020

based on heuristic

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Association between statin use and Alzheimer's disease

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based on heuristic

inferred from PubMed ID database lookup

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10.1016/J.PHRS.2010.12.007

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

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