Alzheimer's disease and cholesterol: the fat connection (Q36693396)

15 August 2017

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title

Alzheimer's disease and cholesterol: the fat connection (English)

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15 August 2017

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Laura Canevari

1

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15 August 2017

John B Clark

series ordinal

2

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15 August 2017

publication date

27 December 2006

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15 August 2017

published in

Neurochemical Research

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15 August 2017

volume

32

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15 August 2017

issue

4-5

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15 August 2017

page(s)

739-750

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Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APP(SW) mice

15 August 2017

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12 December 2020

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Concentrations of pravastatin and lovastatin in cerebrospinal fluid in healthy subjects.

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Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease

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12 December 2020

Plasma 24S-hydroxycholesterol: a peripheral indicator of neuronal degeneration and potential state marker for Alzheimer's disease.

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12 December 2020

Apolipoprotein E and cholesterol affect neuronal calcium signalling: the possible relationship to beta-amyloid neurotoxicity

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12 December 2020

Intracellular calcium changes in neuronal cells induced by Alzheimer's beta-amyloid protein are blocked by estradiol and cholesterol

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12 December 2020

Statins and the risk of dementia

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12 December 2020

Role of cholesterol and lipid organization in disease

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12 December 2020

ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.

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12 December 2020

Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase.

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12 December 2020

Cholesterol paradox: is high total or low HDL cholesterol level a risk for Alzheimer's disease?

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12 December 2020

Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

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12 December 2020

The neurobiology of apolipoproteins and their receptors in the CNS and Alzheimer's disease

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12 December 2020

Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin

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12 December 2020

Mechanisms of statin-mediated inhibition of small G-protein function

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12 December 2020

Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain.

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12 December 2020

Relative risk of Alzheimer disease and age-at-onset distributions, based on APOE genotypes among elderly African Americans, Caucasians, and Hispanics in New York City.

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12 December 2020

Reduction in levels of 24S-hydroxycholesterol by statin treatment in patients with Alzheimer disease

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12 December 2020

Purification of apolipoprotein E attenuates isoform-specific binding to beta-amyloid

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12 December 2020

Statin treatment and a disease-specific pattern of beta-amyloid peptides in Alzheimer's disease

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12 December 2020

The role of oxidative abnormalities in the pathophysiology of Alzheimer's disease.

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12 December 2020

Accumulation and aggregation of amyloid beta-protein in late endosomes of Niemann-pick type C cells

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12 December 2020

Do statins reduce risk of incident dementia and Alzheimer disease? The Cache County Study.

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12 December 2020

Body cholesterol metabolism in man. I. The equilibration of serum and tissue cholesterol

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12 December 2020

Metal ions, pH, and cholesterol regulate the interactions of Alzheimer's disease amyloid-beta peptide with membrane lipid

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12 December 2020

Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease

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12 December 2020

Membrane cholesterol interferes with neuronal apoptosis induced by soluble oligomers but not fibrils of amyloid-beta peptide

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12 December 2020

Cholesterol distribution, not total levels, correlate with altered amyloid precursor protein processing in statin-treated mice

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12 December 2020

Serum cholesterol and risk of Alzheimer disease: a community-based cohort study.

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12 December 2020

Apolipoprotein E is a prime suspect, not just an accomplice, in Alzheimer's disease.

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12 December 2020

A receptor-mediated pathway for cholesterol homeostasis

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12 December 2020

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

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12 December 2020

Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide

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12 December 2020

A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease

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12 December 2020

24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regulates apolipoprotein E-mediated cholesterol efflux.

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12 December 2020

Amyloid beta-peptide and oxidative cellular injury in Alzheimer's disease

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12 December 2020

Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal

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12 December 2020

Recent advances in membrane microdomains: rafts, caveolae, and intracellular cholesterol trafficking

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12 December 2020

Plasma membrane cholesterol controls the cytotoxicity of Alzheimer's disease AbetaP (1-40) and (1-42) peptides.

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12 December 2020

Implication of apoE isoforms in cholesterol metabolism by primary rat hippocampal neurons and astrocytes

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12 December 2020

Lack of association of the cholesterol 24-hydroxylase (CYP46) intron 2 polymorphism with Alzheimer's disease

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12 December 2020

Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration.

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12 December 2020

Modulation of secreted beta-amyloid precursor protein and amyloid beta-peptide in brain by cholesterol

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12 December 2020

Influence of the apolipoprotein E genotype on amyloid deposition and neurofibrillary tangle formation in Alzheimer's disease.

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12 December 2020

Increased neuronal damage and apoE immunoreactivity in human apolipoprotein E, E4 isoform-specific, transgenic mice after global cerebral ischaemia.

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12 December 2020

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

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12 December 2020

Soluble oligomers of amyloid-beta peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway

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12 December 2020

Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro

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12 December 2020

Lipid rafts determine efficiency of NADPH oxidase activation in neutrophils

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12 December 2020

A cluster of cholesterol-related genes confers susceptibility for Alzheimer's disease.

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12 December 2020

Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial

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12 December 2020

Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

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12 December 2020

Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation

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12 December 2020

Cholesterol protects PC12 cells from beta-amyloid induced calcium disordering and cytotoxicity.

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12 December 2020

Fibrillar amyloid-beta peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase. Implications for Alzheimer's disease

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12 December 2020

Activation of NADPH oxidase in Alzheimer's disease brains.

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12 December 2020

APOE promoter, ACE1 and CYP46 polymorphisms and beta-amyloid in Alzheimer's disease

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12 December 2020

Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture

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12 December 2020

Amyloid beta-protein interactions with membranes and cholesterol: causes or casualties of Alzheimer's disease

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12 December 2020

Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels

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12 December 2020

Oxysterol-induced activation of macrophage NADPH-oxidase enhances cell-mediated oxidation of LDL in the atherosclerotic apolipoprotein E deficient mouse: inhibitory role for vitamin E.

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12 December 2020

Cholesterol is necessary both for the toxic effect of Abeta peptides on vascular smooth muscle cells and for Abeta binding to vascular smooth muscle cell membranes

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12 December 2020

Amyloid beta-peptide effects on synaptosomes from apolipoprotein E-deficient mice.

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12 December 2020

Cholesterol, a modulator of membrane-associated Abeta-fibrillogenesis and neurotoxicity.

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12 December 2020

The intracellular domain of amyloid precursor protein interacts with flotillin-1, a lipid raft protein

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12 December 2020

Cholesterol Modulates Amyloid Beta-peptide’s Membrane Interactions

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12 December 2020

CNS synaptogenesis promoted by glia-derived cholesterol

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12 December 2020

Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity

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12 December 2020

Expression and modulation of an NADPH oxidase in mammalian astrocytes.

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12 December 2020

Role of the apolipoprotein E polymorphism in determining normal plasma lipid and lipoprotein variation

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12 December 2020

Amyloid-beta peptide is toxic to neurons in vivo via indirect mechanisms.

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12 December 2020

Astrocytosis, microgliosis, metallothionein-I-II and amyloid expression in high cholesterol-fed rabbits.

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12 December 2020

Differential expression of cholesterol hydroxylases in Alzheimer's disease

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12 December 2020

Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation

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12 December 2020

Functional rafts in cell membranes

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12 December 2020

Atorvastatin for the treatment of mild to moderate Alzheimer disease: preliminary results.

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12 December 2020

Anti-apoptotic effect of atorvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, on cardiac myocytes through protein kinase C activation

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12 December 2020

The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease.

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12 December 2020

Apolipoprotein E polymorphism and acute ischemic stroke: a diffusion- and perfusion-weighted magnetic resonance imaging study

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12 December 2020

Amyloid ion channels: a common structural link for protein-misfolding disease

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12 December 2020

Cholesterol depletion reduces aggregation of amyloid-beta peptide in hippocampal neurons.

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12 December 2020

Re-assessing the relationship between cholesterol, statins and Alzheimer's disease

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12 December 2020

Isoform-specific effect of apolipoprotein E on cell survival and beta-amyloid-induced toxicity in rat hippocampal pyramidal neuronal cultures.

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12 December 2020

Cholesterol, statins and dementia.

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12 December 2020

Lovastatin enhances Abeta production and senile plaque deposition in female Tg2576 mice

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12 December 2020

Effects of statins on endothelium and signaling mechanisms

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12 December 2020

Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

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12 December 2020

Neuronal membrane cholesterol loss enhances amyloid peptide generation

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12 December 2020

Genetic variants of ABCA1 modify Alzheimer disease risk and quantitative traits related to beta-amyloid metabolism

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12 December 2020

Oxidative metabolites accelerate Alzheimer's amyloidogenesis by a two-step mechanism, eliminating the requirement for nucleation

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12 December 2020

Isoform-specific interactions of human apolipoprotein E to an intermediate conformation of human Alzheimer amyloid-beta peptide.

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12 December 2020

beta-amyloid activates the O-2 forming NADPH oxidase in microglia, monocytes, and neutrophils. A possible inflammatory mechanism of neuronal damage in Alzheimer's disease

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12 December 2020

An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha

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12 December 2020

Apolipoprotein E genotype and deposits of Abeta40 and Abeta42 in Alzheimer disease

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12 December 2020

Effects of lovastatin and pravastatin on amyloid processing and inflammatory response in TgCRND8 brain

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12 December 2020

Cholesterol synthesis rate in human hippocampus declines with aging.

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12 December 2020

Altered membrane fluidity and lipid raft composition in presenilin-deficient cells

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12 December 2020

Induction of Alzheimer-like beta-amyloid immunoreactivity in the brains of rabbits with dietary cholesterol

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12 December 2020

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

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12 December 2020

Cholesterol, copper and Abeta in controls, MCI, AD and the AD cholesterol-lowering treatment trial (ADCLT).

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12 December 2020

Use of in vivo models to study the role of cholesterol in the etiology of Alzheimer's disease.

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12 December 2020

Is hypercholesterolemia a risk factor for Alzheimer's disease?

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12 December 2020

A novel pleiotropic effect of statins: prevention of cardiac hypertrophy by cholesterol-independent mechanisms

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12 December 2020

On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells

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12 December 2020

High-dose statins and skeletal muscle metabolism in humans: a randomized, controlled trial

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12 December 2020

Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study

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12 December 2020

Metabolism of cholesterol and triacylglycerol in cultured chick neuronal cells, glial cells, and fibroblasts: accumulation of esterified cholesterol in serum-free culture

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12 December 2020

Statin effects on cholesterol micro-domains in brain plasma membranes

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12 December 2020

Quantitative imaging of glutathione in hippocampal neurons and glia in culture using monochlorobimane

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12 December 2020

Simvastatin affects cell motility and actin cytoskeleton distribution of microglia

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12 December 2020

Caveolin, a protein component of caveolae membrane coats

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12 December 2020

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

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12 December 2020

The phagocyte NADPH oxidase depends on cholesterol-enriched membrane microdomains for assembly

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12 December 2020

Relation of plasma lipids to Alzheimer disease and vascular dementia

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12 December 2020

Effect of sterols on beta-amyloid peptide (AbetaP 1-40) channel formation and their properties in planar lipid membranes

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12 December 2020

Cholesterol modulates the membrane-disordering effects of beta-amyloid peptides in the hippocampus: specific changes in Alzheimer's disease.

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12 December 2020

Apolipoprotein E ε4 allele is associated with deposition of amyloid β-protein following head injury

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12 December 2020

Cholesterol-dependent Generation of a Seeding Amyloid β-Protein in Cell Culture

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12 December 2020

Tangle-bearing neurons contain more free cholesterol than adjacent tangle-free neurons.

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12 December 2020

Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease

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12 December 2020

A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes

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12 December 2020

Statins cause intracellular accumulation of amyloid precursor protein, beta-secretase-cleaved fragments, and amyloid beta-peptide via an isoprenoid-dependent mechanism.

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12 December 2020

Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity.

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12 December 2020

Isolation of a mammalian cell mutant resistant to 25-hydroxy cholesterol

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12 December 2020

Apolipoprotein E and Alzheimer disease.

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12 December 2020

Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex

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12 December 2020

Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts

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12 December 2020

Reduction of plasma 24S-hydroxycholesterol (cerebrosterol) levels using high-dosage simvastatin in patients with hypercholesterolemia: evidence that simvastatin affects cholesterol metabolism in the human brain

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12 December 2020

Time course of biosynthetic cholesterol in the adult rat brain.

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12 December 2020

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

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12 December 2020

Effects of aging and beta-amyloid on the properties of brain synaptic and mitochondrial membranes

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12 December 2020

Mitochondrial damage in Alzheimer's disease varies with apolipoprotein E genotype.

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12 December 2020

10.1007/S11064-006-9200-1

Identifiers

DOI

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15 August 2017

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