The stress protein BAG3 stabilizes Mcl-1 protein and promotes survival of cancer cells and resistance to antagonist ABT-737 (Q34557856)

3 August 2017

title

The stress protein BAG3 stabilizes Mcl-1 protein and promotes survival of cancer cells and resistance to antagonist ABT-737 (English)

1 reference

3 August 2017

Mariana Boiani

1

1 reference

3 August 2017

Cristina Daniel

2

1 reference

3 August 2017

Xueyuan Liu

3

1 reference

3 August 2017

Michael D Hogarty

4

1 reference

3 August 2017

Lawrence J Marnett

5

1 reference

3 August 2017

language of work or name

English

0 references

publication date

22 January 2013

1 reference

Journal of Biological Chemistry

3 August 2017

published in

1 reference

3 August 2017

volume

288

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3 August 2017

issue

10

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3 August 2017

page(s)

6980-6990

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HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers

3 August 2017

cites work

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7 July 2018

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Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

7 July 2018

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HSF1-mediated BAG3 expression attenuates apoptosis in 4-hydroxynonenal-treated colon cancer cells via stabilization of anti-apoptotic Bcl-2 proteins

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Down-regulation of myeloid cell leukemia-1 through inhibiting Erk/Pin 1 pathway by sorafenib facilitates chemosensitization in breast cancer

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation

7 July 2018

1 reference

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The antiapoptotic protein BAG3 is expressed in thyroid carcinomas and modulates apoptosis mediated by tumor necrosis factor-related apoptosis-inducing ligand.

7 July 2018

1 reference

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

7 July 2018

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7 July 2018

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BAG3 deficiency results in fulminant myopathy and early lethality

7 July 2018

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7 July 2018

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Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

7 July 2018

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7 July 2018

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Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

7 July 2018

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7 July 2018

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

7 July 2018

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7 July 2018

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Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells

7 July 2018

1 reference

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7 July 2018

1 reference

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MCL-1 expression in B-cell non-Hodgkin's lymphomas

7 July 2018

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MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol

7 July 2018

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Characterisation of Mcl-1 cleavage during apoptosis of haematopoietic cells

7 July 2018

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7 July 2018

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Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation

7 July 2018

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CAIR-1/BAG-3 abrogates heat shock protein-70 chaperone complex-mediated protein degradation: accumulation of poly-ubiquitinated Hsp90 client proteins

7 July 2018

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What's in the 'BAG'?--A functional domain analysis of the BAG-family proteins.

7 July 2018

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

7 July 2018

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7 July 2018

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MCL1 provides a window on the role of the BCL2 family in cell proliferation, differentiation and tumorigenesis

7 July 2018

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The anti-apoptotic protein BAG-3 is overexpressed in pancreatic cancer and induced by heat stress in pancreatic cancer cell lines

7 July 2018

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7 July 2018

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The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

7 July 2018

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The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2

7 July 2018

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Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity

7 July 2018

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Immunohistochemical analysis of Mcl-1 protein in human tissues. Differential regulation of Mcl-1 and Bcl-2 protein production suggests a unique role for Mcl-1 in control of programmed cell death in vivo.

7 July 2018

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Oncogenic potential of bcl-2 demonstrated by gene transfer.

7 July 2018

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Antisense-mediated inhibition of BCL2 protooncogene expression and leukemic cell growth and survival: comparisons of phosphodiester and phosphorothioate oligodeoxynucleotides

7 July 2018

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Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-x(L) is an essential survival protein of human myeloma cells.

7 July 2018

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Crossref

https://api.crossref.org/works/10.1074%2FJBC.M112.414177

[Bag3 gene expression in chronic lymphocytic leukemia and its association with patients' prognosis].

21 January 2018

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Genome-wide array CGH analysis of murine neuroblastoma reveals distinct genomic aberrations which parallel those in human tumors.

27 October 2018

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In vivo localisation and stability of human Mcl-1 using green fluorescent protein (GFP) fusion proteins

27 October 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/23341456

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A matter of life and death

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23341456

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M112.414177

1 reference

3 August 2017

1 reference

3 August 2017

1 reference