Crippling p53 activities via knock-in mutations in mouse models (Q34614596)

3 August 2017

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title

Crippling p53 activities via knock-in mutations in mouse models (English)

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3 August 2017

T Iwakuma

1

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3 August 2017

G Lozano

series ordinal

2

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3 August 2017

language of work or name

English

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publication date

1 April 2007

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3 August 2017

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3 August 2017

26

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3 August 2017

15

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3 August 2017

2177-2184

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1210278

3 August 2017

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cites work

Hypoxia attenuates the p53 response to cellular damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Post-translational modifications and activation of p53 by genotoxic stresses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

The effects of wild-type p53 tumor suppressor activity and mutant p53 gain-of-function on cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Regulation of p53 activity through lysine methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Novel phosphorylation sites of human tumour suppressor protein p53 at Ser20 and Thr18 that disrupt the binding of mdm2 (mouse double minute 2) protein are modified in human cancers

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Transcriptional activation by p53 correlates with suppression of growth but not transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Expression and stability of p53 protein in normal human mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Modulation of binding of DNA to the C-terminal domain of p53 by acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Identification of a sequence element from p53 that signals for Mdm2-targeted degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Mutation of phosphoserine 389 affects p53 function in vivo

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Neddylating the guardian; Mdm2 catalyzed conjugation of Nedd8 to p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

p53 mutations in human cancers

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Allosteric activation of latent p53 tetramers

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

TP53 mutation in colorectal cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Li-Fraumeni syndrome: a p53 family affair

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Mutation at p53 serine 389 does not rescue the embryonic lethality in mdm2 or mdm4 null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

p53QS: an old mutant teaches us new tricks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

The complexity of p53 stabilization and activation

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

The tumor suppressor genes

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

High metastatic potential in mice inheriting a targeted p53 missense mutation

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

p53 mutations in benzo(a)pyrene-exposed human p53 knock-in murine fibroblasts correlate with p53 mutations in human lung tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Ultraviolet radiation, but not gamma radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Knock-in mice with a chimeric human/murine p53 gene develop normally and show wild-type p53 responses to DNA damaging agents: a new biomedical research tool.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

p53 linear diffusion along DNA requires its C terminus

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Mutation of the casein kinase II phosphorylation site abolishes the anti-proliferative activity of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

SUMO-1 modification activates the transcriptional response of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Mutant p53: gain-of-function oncoproteins and wild-type p53 inactivators

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Phosphorylation of serine 18 regulates distinct p53 functions in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Physical interaction with human tumor-derived p53 mutants inhibits p63 activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

The alpha-helical FXXPhiPhi motif in p53: TAF interaction and discrimination by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

p53 function and dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Mutation of mouse p53 Ser23 and the response to DNA damage

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

p73 function is inhibited by tumor-derived p53 mutants in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

7 January 2021

Effects of genetic background on tumorigenesis in p53-deficient mice

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

7 January 2021

The role of UV-B light in skin carcinogenesis through the analysis of p53 mutations in squamous cell carcinomas of hairless mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

7 January 2021

Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

7 January 2021

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

7 January 2021

Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

7 January 2021

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

7 January 2021

Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

7 January 2021

Phosphorylation of serine 392 stabilizes the tetramer formation of tumor suppressor protein p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210278

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1210278

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Dimensions Publication ID

3 August 2017

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1 reference