Mystery of DNA repair: the role of the MRN complex and ATM kinase in DNA damage repair (Q34657712)

3 August 2017

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title

Mystery of DNA repair: the role of the MRN complex and ATM kinase in DNA damage repair (English)

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3 August 2017

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3

Krystyna H Chrzanowska

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3 August 2017

Kamila Czornak

1

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PubMed ID

19029686

3 August 2017

Sanaullah Chughtai

series ordinal

2

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3 August 2017

1 January 2008

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Journal of Applied Genetics

3 August 2017

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3 August 2017

49

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3 August 2017

4

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3 August 2017

383-396

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https://scigraph.springernature.com/pub.10.1007/bf03195638

3 August 2017

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cites work

Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FBF03195638

Current topics in DNA double-strand break repair

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FBF03195638

hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FBF03195638

The Werner syndrome protein is a DNA helicase

21 January 2018

1 reference

12 December 2020

Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.

1 reference

12 December 2020

Molecular pathogenesis of Fanconi anemia: recent progress

1 reference

12 December 2020

MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control

1 reference

12 December 2020

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

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12 December 2020

The many substrates and functions of ATM

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12 December 2020

ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks

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12 December 2020

Cell cycle checkpoint signaling through the ATM and ATR kinases

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12 December 2020

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12 December 2020

Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV

1 reference

12 December 2020

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

1 reference

12 December 2020

Breast cancer predisposing alleles in Poland

1 reference

12 December 2020

Nijmegen breakage syndrome: clinical manifestation of defective response to DNA double-strand breaks

1 reference

12 December 2020

A novel function of Rad54 protein. Stabilization of the Rad51 nucleoprotein filament

1 reference

12 December 2020

MRE11/RAD50/NBS1: complex activities

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12 December 2020

Homologous recombination in DNA repair and DNA damage tolerance

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12 December 2020

The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM.

1 reference

12 December 2020

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

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12 December 2020

The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres

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12 December 2020

Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex.

1 reference

12 December 2020

Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis

1 reference

12 December 2020

Clinical ascertainment of Nijmegen breakage syndrome (NBS) and prevalence of the major mutation, 657del5, in three Slav populations

1 reference

12 December 2020

Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

1 reference

12 December 2020

Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.

1 reference

12 December 2020

Increased risk of gastrointestinal lymphoma in carriers of the 657del5 NBS1 gene mutation

1 reference

12 December 2020

The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

1 reference

12 December 2020

A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome

1 reference

12 December 2020

ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses

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12 December 2020

Involvement of novel autophosphorylation sites in ATM activation

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12 December 2020

657del5 mutation in the gene for Nijmegen breakage syndrome (NBS1) in a cohort of Russian children with lymphoid tissue malignancies and controls

1 reference

12 December 2020

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

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12 December 2020

Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

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12 December 2020

Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.

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12 December 2020

Enhanced phosphorylation of p53 by ATM in response to DNA damage

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12 December 2020

Identification and functional consequences of a novel MRE11 mutation affecting 10 Saudi Arabian patients with the ataxia telangiectasia-like disorder.

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12 December 2020

Role of the Nijmegen breakage syndrome 1 gene in familial and sporadic prostate cancer.

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12 December 2020

Signaling networks controlled by the MRN complex and MDC1 during early DNA damage responses

1 reference

12 December 2020

Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes

1 reference

12 December 2020

Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging

1 reference

12 December 2020

Functional human telomeres are recognized as DNA damage in G2 of the cell cycle

1 reference

12 December 2020

The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair

1 reference

12 December 2020

Primary immunodeficiency syndromes associated with defective DNA double-strand break repair

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12 December 2020

MDC1 is required for the intra-S-phase DNA damage checkpoint

1 reference

12 December 2020

Chromosomal stability and the DNA double-stranded break connection

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12 December 2020

DNA replication-dependent nuclear dynamics of the Mre11 complex.

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12 December 2020

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

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12 December 2020

The Bloom's syndrome gene product is homologous to RecQ helicases

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12 December 2020

Germline 657del5 mutation in the NBS1 gene in patients with malignant melanoma of the skin.

1 reference

12 December 2020

Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells

1 reference

12 December 2020

Unusual features in the inheritance of ataxia telangiectasia

1 reference

12 December 2020

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

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12 December 2020

Germline NBS1 mutations in families with aggregation of Breast and/or ovarian cancer from north-east Poland

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12 December 2020

Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4

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12 December 2020

Nijmegen Breakage Syndrome mutations and risk of breast cancer

1 reference

12 December 2020

Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase.

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12 December 2020

Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination

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12 December 2020

Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage

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12 December 2020

The DNA damage response: putting checkpoints in perspective

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12 December 2020

The role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint control

1 reference

12 December 2020

Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

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12 December 2020

Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks

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12 December 2020

The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

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12 December 2020

Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation

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12 December 2020

DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension

1 reference

12 December 2020

Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

1 reference

12 December 2020

Replication protein A is required for etoposide-induced assembly of MRE11/RAD50/NBS1 complex repair foci.

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12 December 2020

Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responses

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12 December 2020

Telomere dysfunction in genome instability syndromes.

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12 December 2020

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

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12 December 2020

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12 December 2020

The rad50 signature motif: essential to ATP binding and biological function

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12 December 2020

The incidence and gene frequency of ataxia-telangiectasia in the United States

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12 December 2020

Specific interactions between the human RAD51 and RAD52 proteins

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12 December 2020

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12 December 2020

DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex

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12 December 2020

Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair

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12 December 2020

Purification and characterization of the human Rad51 protein, an analogue of E. coli RecA

1 reference

12 December 2020

MRE11 mutations and impaired ATM-dependent responses in an Italian family with ataxia-telangiectasia-like disorder

1 reference

12 December 2020

The MRN complex: coordinating and mediating the response to broken chromosomes

1 reference

12 December 2020

ATM-dependent phosphorylation of nibrin in response to radiation exposure

1 reference

12 December 2020

Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly

1 reference

12 December 2020

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

1 reference

12 December 2020

Human Rad50/Mre11 is a flexible complex that can tether DNA ends

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12 December 2020

ATM phosphorylates histone H2AX in response to DNA double-strand breaks

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12 December 2020

ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation

1 reference

12 December 2020

FAT: a novel domain in PIK-related kinases

1 reference

12 December 2020

ATM associates with and phosphorylates p53: mapping the region of interaction

1 reference

12 December 2020

Founder mutations in early-onset, familial and bilateral breast cancer patients from Russia

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12 December 2020

A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM

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12 December 2020

Cancer risk of heterozygotes with the NBN founder mutation.

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12 December 2020

The Nijmegen breakage syndrome protein is essential for Mre11 phosphorylation upon DNA damage

1 reference

12 December 2020

Interaction between ATM protein and c-Abl in response to DNA damage

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12 December 2020

Detection of a tandem BRCT in Nbs1 and Xrs2 with functional implications in the DNA damage response

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12 December 2020

The importance of making ends meet: mutations in genes and altered expression of proteins of the MRN complex and cancer

1 reference

12 December 2020

Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA

1 reference

12 December 2020

Nijmegen breakage syndrome. The International Nijmegen Breakage Syndrome Study Group

1 reference

12 December 2020

Intermediates of recombination during mating type switching in Saccharomyces cerevisiae

1 reference

12 December 2020

The ATM-mediated DNA-damage response: taking shape.

1 reference

12 December 2020

Cancer incidence in Nijmegen breakage syndrome is modulated by the amount of a variant NBS protein.

1 reference

12 December 2020

Carrier frequency of mutation 657del5 in the NBS1 gene in a population of Polish pediatric patients with sporadic lymphoid malignancies

1 reference

12 December 2020

The endless tale of non-homologous end-joining

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12 December 2020

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

1 reference

12 December 2020

Increased cancer risk of heterozygotes with NBS1 germline mutations in Poland

1 reference

12 December 2020

A single-stranded DNA-binding protein is needed for efficient presynaptic complex formation by the Saccharomyces cerevisiae Rad51 protein

1 reference

12 December 2020

DNA double-strand breaks: signaling, repair and the cancer connection

1 reference

12 December 2020

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

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12 December 2020

An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele

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12 December 2020

Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice.

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12 December 2020

Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95

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12 December 2020

Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway

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12 December 2020

Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways

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12 December 2020

Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control.

1 reference

12 December 2020

Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

1 reference

12 December 2020

NBS1 is a prostate cancer susceptibility gene.

1 reference

12 December 2020

Regulation of telomerase by telomeric proteins

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12 December 2020

Functional diversity of human protection of telomeres 1 isoforms in telomere protection and cellular senescence

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12 December 2020

Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation

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12 December 2020

DNA-binding and strand-annealing activities of human Mre11: implications for its roles in DNA double-strand break repair pathways

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12 December 2020

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

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12 December 2020

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

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12 December 2020

Ataxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage.

1 reference

12 December 2020

DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency

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12 December 2020

Identifiers

DOI

10.1007/BF03195638

1 reference

release_2jxdewphkjhwhotqoh2kcezjq4

3 August 2017

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Fatcat

https://api.fatcat.wiki/v0/release/2jxdewphkjhwhotqoh2kcezjq4

24 November 2022

mapped directly with Wikidata item

PubMed ID

19029686

1 reference

PubMed ID

19029686