The role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint control (Q28296356)

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

Europe PubMed Central

title

The role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint control (English)

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author name string

Ying Zhang

series ordinal

1

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Junqing Zhou

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2

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Chang Uk Lim

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3

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language of work or name

English

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publication date

January 2006

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published in

Cell Research

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volume

16

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issue

1

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page(s)

45-54

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cites work

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The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

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Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

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Interaction of FANCD2 and NBS1 in the DNA damage response

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Cell cycle checkpoint signaling through the ATM and ATR kinases

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Switching and signaling at the telomere

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Protection of mammalian telomeres

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Nijmegen breakage syndrome gene, NBS1, and molecular links to factors for genome stability

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Fatal toxicity following radio- and chemotherapy of medulloblastoma in a child with unrecognized Nijmegen breakage syndrome

21 January 2018

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Sequence analysis of an 800-kb genomic DNA region on chromosome 8q21 that contains the Nijmegen breakage syndrome gene, NBS1.

21 January 2018

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Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells

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Nijmegen Breakage syndrome: a progress report

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Expression pattern of the Nijmegen breakage syndrome gene, Nbs1, during murine development

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Therapy for non-Hodgkin lymphoma in children with primary immunodeficiency: analysis of 19 patients from the BFM trials.

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Nijmegen breakage syndrome: clinical characteristics and mutation analysis in eight unrelated Russian families

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Transcriptional coactivator Drosophila eyes absent homologue 2 is up-regulated in epithelial ovarian cancer and promotes tumor growth.

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Nijmegen breakage syndrome and DNA double strand break repair by NBS1 complex

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A murine model of Nijmegen breakage syndrome

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An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele

21 January 2018

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Distinct pathways of nonhomologous end joining that are differentially regulated by DNA-dependent protein kinase-mediated phosphorylation

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Initiating cellular stress responses

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Requirement of the MRN complex for ATM activation by DNA damage

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The Mre11 complex is required for ATM activation and the G2/M checkpoint

21 January 2018

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Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

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Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation

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Nbs1 is required for ATR-dependent phosphorylation events

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The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50[middle dot]hMRE11[middle dot]NBS1 complex DNA repair activity

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ATM signaling and genomic stability in response to DNA damage

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The Nijmegen breakage syndrome protein is essential for Mre11 phosphorylation upon DNA damage

21 January 2018

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Checking on the fork: the DNA-replication stress-response pathway

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Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II

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Telomeres and their control

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The kinase activity of DNA-PK is required to protect mammalian telomeres

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Dysfunctional mammalian telomeres join with DNA double-strand breaks

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Telomere maintenance is dependent on activities required for end repair of double-strand breaks

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T-loops and the origin of telomeres

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Recombination in telomere-length maintenance

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The Nijmegen breakage syndrome gene and its role in genome stability

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Telomere maintenance and cell cycle regulation in spontaneously immortalized T-cell lines from Nijmegen breakage syndrome patients.

21 January 2018

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ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

21 January 2018

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Radiosensitivity in ataxia-telangiectasia: a new explanation

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Nijmegen breakage syndrome: clinical manifestation of defective response to DNA double-strand breaks

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The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways

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NBS1 and its functional role in the DNA damage response

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Differing responses of Nijmegen breakage syndrome and ataxia telangiectasia cells to ionizing radiation

21 January 2018

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21 January 2018

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Cell cycle checkpoints and DNA repair in Nijmegen breakage syndrome

21 January 2018

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Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation

21 January 2018

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Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes

21 January 2018

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NBS1 knockdown by small interfering RNA increases ionizing radiation mutagenesis and telomere association in human cells

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7 January 2021

The many interfaces of Mre11

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7 January 2021

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7 January 2021

Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest

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7 January 2021

Loss of a yeast telomere: arrest, recovery, and chromosome loss.

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7 January 2021

Alteration of telomeric sequences and senescence caused by mutations in RAD50 of Saccharomyces cerevisiae

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7 January 2021