Sequence-specific interactions of drugs interfering with the topoisomerase-DNA cleavage complex (Q34707948)

4 August 2017

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title

Sequence-specific interactions of drugs interfering with the topoisomerase-DNA cleavage complex (English)

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4 August 2017

Barbara Gatto

2

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Manlio Palumbo

object named as

Manlio Palumbo

1

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Stefano Moro

object named as

Stefano Moro

3

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author name string

Claudia Sissi

4

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4 August 2017

Giuseppe Zagotto

5

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4 August 2017

language of work or name

English

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publication date

1 July 2002

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4 August 2017

number of pages

10

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Biochimica et Biophysica Acta

inferred from page(s)

published in

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4 August 2017

volume

1587

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4 August 2017

issue

2-3

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4 August 2017

page(s)

145-154

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4 August 2017

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Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme

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Functional and regulatory characteristics of eukaryotic type II DNA topoisomerase

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The mechanism of type IA topoisomerase-mediated DNA topological transformations

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Catalytic mechanism of DNA topoisomerase IB.

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DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis

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Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia

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7 January 2021

Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme

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7 January 2021

Topoisomerase I poisons and suppressors as anticancer drugs

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7 January 2021

Mapping drug interactions at the covalent topoisomerase II-DNA complex by bisantrene/amsacrine congeners.

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7 January 2021

Analysis of etoposide binding to subdomains of human DNA topoisomerase II alpha in the absence of DNA.

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7 January 2021

Mechanism of cytotoxicity of N-[2-(dimethylamino)ethyl] acridine-4-carboxamide and of its 7-chloro derivative: the roles of topoisomerases I and II.

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7 January 2021

Bis(phenazine-1-carboxamides): structure-activity relationships for a new class of dual topoisomerase I/II-directed anticancer drugs

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A dual topoisomerase inhibitor, TAS-103, induces apoptosis in human cancer cells

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Acetyl-boswellic acids are novel catalytic inhibitors of human topoisomerases I and IIalpha.

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F 11782, a novel epipodophylloid non-intercalating dual catalytic inhibitor of topoisomerases I and II with an original mechanism of action

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Distribution of topoisomerase II cleavage sites in simian virus 40 DNA and the effects of drugs

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DNA sequence selectivity of topoisomerases and topoisomerase poisons.

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Eukaryotic topoisomerase II preferentially cleaves alternating purine-pyrimidine repeats

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A protein-mediated mechanism for the DNA sequence-specific action of topoisomerase II poisons.

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Localization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complex

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Interaction of an alkylating camptothecin derivative with a DNA base at topoisomerase I-DNA cleavage sites

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Site-specific topoisomerase I-mediated DNA cleavage induced by nogalamycin: a potential role of ligand-induced DNA bending at a distal site

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Cytosine arabinoside lesions are position-specific topoisomerase II poisons and stimulate DNA cleavage mediated by the human type II enzymes

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Molecular analysis of yeast and human type II topoisomerases. Enzyme-DNA and drug interactions.

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Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA

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Molecular modeling studies of the DNA-topoisomerase I ternary cleavable complex with camptothecin

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7 January 2021

A structural model for the ternary cleavable complex formed between human topoisomerase I, DNA, and camptothecin

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Homocamptothecin, an E-ring-modified camptothecin analogue, generates new topoisomerase I-mediated DNA breaks.

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7 January 2021

DNA-binding preferences of bisantrene analogues: relevance to the sequence specificity of drug-mediated topoisomerase II poisoning

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Bisindolylmaleimides linked to DNA minor groove binding lexitropsins: synthesis, inhibitory activity against topoisomerase I, and biological evaluation

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7 January 2021

Camptothecin and minor-groove binder hybrid molecules: synthesis, inhibition of topoisomerase I, and anticancer cytotoxicity in vitro

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Sequence-Specific DNA Minor Groove Binders. Design and Synthesis of Netropsin and Distamycin Analogues

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Sequence-specific trapping of topoisomerase I by DNA binding polyamide-camptothecin conjugates

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Triple helix-forming oligonucleotides conjugated to indolocarbazole poisons direct topoisomerase I-mediated DNA cleavage to a specific site.

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7 January 2021

Topoisomerase II-mediated site-directed alkylation of DNA by psorospermin and its use in mapping other topoisomerase II poison binding sites

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7 January 2021

Topoisomerase II site-directed alkylation of DNA by psorospermin and its effect on topoisomerase II-mediated DNA cleavage.

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7 January 2021

Poisoning of human DNA topoisomerase I by ecteinascidin 743, an anticancer drug that selectively alkylates DNA in the minor groove

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Phthalascidin, a synthetic antitumor agent with potency and mode of action comparable to ecteinascidin 743.

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Investigation of the biological mode of action of clerocidin using whole cell assays

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The topoisomerase II poison clerocidin alkylates non-paired guanines of DNA: implications for irreversible stimulation of DNA cleavage

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The distribution and expression of the two isoforms of DNA topoisomerase II in normal and neoplastic human tissues

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Differential expression of the topoisomerase II alpha and beta genes in human breast cancers

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DNA topoisomerase II isozymes involved in anticancer drug action and resistance

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Relationship between expression of topoisomerase II isoforms and intrinsic sensitivity to topoisomerase II inhibitors in breast cancer cell lines

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7 January 2021

Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage

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7 January 2021

Carbamate analogues of amsacrine active against non-cycling cells: relative activity against topoisomerases IIalpha and beta

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7 January 2021

Altered drug interaction and regulation of topoisomerase IIbeta: potential mechanisms governing sensitivity of HL-60 cells to amsacrine and etoposide.

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7 January 2021

Topoisomerase poisoning activity of novel disaccharide anthracyclines

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7 January 2021

Murine transgenic cells lacking DNA topoisomerase IIbeta are resistant to acridines and mitoxantrone: analysis of cytotoxicity and cleavable complex formation.

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7 January 2021

XK469, a selective topoisomerase IIbeta poison

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7 January 2021

Amsacrine-promoted DNA cleavage site determinants for the two human DNA topoisomerase II isoforms alpha and beta

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7 January 2021

Novel HeLa topoisomerase II is the II beta isoform: complete coding sequence and homology with other type II topoisomerases.

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7 January 2021

Genomic sites of topoisomerase II activity determined by comparing DNA breakage enhanced by three distinct poisons

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7 January 2021

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Identifiers

DOI

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4 August 2017

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