Historical claims and current interpretations of replicative aging (Q34713128)

4 August 2017

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title

Historical claims and current interpretations of replicative aging (English)

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4 August 2017

1

Woodring E Wright

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4 August 2017

2

Jerry W Shay

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PubMed ID

12089552

4 August 2017

language of work or name

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1 July 2002

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4 August 2017

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4 August 2017

20

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4 August 2017

682-688

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4 August 2017

7

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https://scigraph.springernature.com/pub.10.1038/nbt0702-682

4 August 2017

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cites work

Advanced glycosylation: chemistry, biology, and implications for diabetes and aging

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7 January 2021

The multistep nature of cancer

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7 January 2021

Specific association of human telomerase activity with immortal cells and cancer

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7 January 2021

A survey of telomerase activity in human cancer

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https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Site-specific DNA damage at GGG sequence by oxidative stress may accelerate telomere shortening

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https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival

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https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Telomerase activity in 'immortal' fish

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https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Cellular senescence: mitotic clock or culture shock?

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https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology

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https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Cellular senescence as a tumor-protection mechanism: the essential role of counting

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita

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https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

A telomerase component is defective in the human disease dyskeratosis congenita

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https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

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https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

The p53 tumor suppressor protein does not regulate expression of its own inhibitor, MDM2, except under conditions of stress

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https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

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https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Atm-deficient mice: a paradigm of ataxia telangiectasia

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https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Postnatal growth failure, short life span, and early onset of cellular senescence and subsequent immortalization in mice lacking the xeroderma pigmentosum group G gene

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

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https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Extended culture of mouse embryo cells without senescence: inhibition by serum.

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Lack of replicative senescence in cultured rat oligodendrocyte precursor cells

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Lack of replicative senescence in normal rodent glia

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Telomere loss: mitotic clock or genetic time bomb?

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts

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https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Is beta-galactosidase staining a marker of senescence in vitro and in vivo?

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells.

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

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https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Senescence of human fibroblasts induced by oncogenic Raf.

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Immortalisation and transformation revisited

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Aging. When do telomeres matter?

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Extension of life-span by introduction of telomerase into normal human cells

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Telomere biology and cellular aging in nonhuman primate cells

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Formation of functional tissue from transplanted adrenocortical cells expressing telomerase reverse transcriptase.

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Cell aging in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Telomerase and cellular lifespan: ending the debate?

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

The relation between lifespan of a species and the number of doublings of its cells in culture is an unresolved issue

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Genetic and epigenetic changes in human epithelial cells immortalized by telomerase

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

The effect of low oxygen tension on the in vitro-replicative life span of human diploid fibroblast cells and their transformed derivatives

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Low oxygen concentration extends the lifespan of cultured human diploid cells

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

N-t-butyl hydroxylamine, a hydrolysis product of alpha-phenyl-N-t-butyl nitrone, is more potent in delaying senescence in human lung fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Thymidine labelling index as a criterion of aging in vitro

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Influence of oxygen and pH on plating efficiency and colony development of WI-38 and Vero cells.

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

The relationships of animal age and caloric intake to cellular replication in vivo and in vitro: a review

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Skeletal muscle satellite cells: changes in proliferation potential as a function of age

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Variation in the life-span of clones derived from human diploid cell strains

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Intraclonal variation in proliferative potential of human diploid fibroblasts: stochastic mechanism for cellular aging

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Colony size distributions as a measure of in vivo and in vitro aging

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Telomeres shorten during ageing of human fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Telomere shortening is proportional to the size of the G-rich telomeric 3'-overhang

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Refining the telomere-telomerase hypothesis of aging and cancer.

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

In vivo loss of telomeric repeats with age in humans

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Telomeric length and telomerase activity vary with age in peripheral blood cells obtained from normal individuals

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Telomere shortening and decline in replicative potential as a function of donor age in human adrenocortical cells

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Frequent p53 accumulation in the chronically sun-exposed epidermis and clonal expansion of p53 mutant cells in the epidermis adjacent to basal cell carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Involvement of follicular stem cells in forming not only the follicle but also the epidermis

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

The small intestine in old mice: Growth, alkaline phosphatase and disaccharidase activities, and deposition of amyloid

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

The relative quiescence of hematopoietic stem cells in nonhuman primates

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Multiple pathways for the regulation of telomerase activity

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Telomerase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

A protein-counting mechanism for telomere length regulation in yeast.

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

The yeast telomere length counting machinery is sensitive to sequences at the telomere-nontelomere junction.

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Telomere states and cell fates

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

A role for both RB and p53 in the regulation of human cellular senescence

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Transient expression of human telomerase extends the life span of normal human fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Preferential maintenance of critically short telomeres in mammalian cells heterozygous for mTert.

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Regulation of telomerase activity in immortal cell lines

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Lack of cell cycle regulation of telomerase activity in human cells

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta.

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Telomerase and differentiation in multicellular organisms: turn it off, turn it on, and turn it off again

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Shorter telomeres in dystrophic muscle consistent with extensive regeneration in young children

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Myoblast senescence in muscular dystrophy

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Defective myoblasts identified in Duchenne muscular dystrophy

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Progressive telomere shortening and telomerase reactivation during hepatocellular carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Telomere shortening in chronic liver diseases

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Telomere length in human liver diseases

1 reference

https://api.crossref.org/works/10.1038%2FNBT0702-682

7 January 2021

Identifiers

DOI

10.1038/NBT0702-682

1 reference

PubMed ID

12089552

Dimensions Publication ID

4 August 2017

0 references

1 reference

PubMed ID

12089552