Obesity therapy: altering the energy intake-and-expenditure balance sheet (Q34743295)

4 August 2017

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title

Obesity therapy: altering the energy intake-and-expenditure balance sheet (English)

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4 August 2017

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Stephen O'Rahilly

3

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author name string

Vivion E F Crowley

series ordinal

1

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4 August 2017

Giles S H Yeo

series ordinal

2

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4 August 2017

language of work or name

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1 April 2002

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Nature Reviews Drug Discovery

4 August 2017

published in

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4 August 2017

volume

1

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4 August 2017

issue

4

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4 August 2017

page(s)

276-286

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Congenital leptin deficiency is associated with severe early-onset obesity in humans

4 August 2017

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Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor

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Alternative role for prolactin-releasing peptide in the regulation of food intake.

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Y-receptor subtypes--how many more?

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Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y.

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Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor.

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Role of the Y5 neuropeptide Y receptor in feeding and obesity

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The melanin-concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization

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Immunohistochemical localization of a melanin concentrating hormone-like peptide in the rat brain.

21 January 2018

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A role for melanin-concentrating hormone in the central regulation of feeding behaviour

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Mice lacking melanin-concentrating hormone are hypophagic and lean

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Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance

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Molecular characterization of the melanin-concentrating-hormone receptor

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Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1

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Identification and characterization of a melanin-concentrating hormone receptor

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Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R

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A role for ghrelin in the central regulation of feeding

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Ghrelin induces adiposity in rodents

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Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues

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A receptor in pituitary and hypothalamus that functions in growth hormone release

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Identification of endocannabinoids and cannabinoid CB(1) receptor mRNA in the pituitary gland

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Low dose anandamide affects food intake, cognitive function, neurotransmitter and corticosterone levels in diet-restricted mice.

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Leptin-regulated endocannabinoids are involved in maintaining food intake

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Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean.

21 January 2018

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21 January 2018

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Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation

21 January 2018

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The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene

21 January 2018

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Towards a molecular understanding of adaptive thermogenesis

21 January 2018

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Thermogenic drugs as a strategy for treatment of obesity

21 January 2018

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A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis

21 January 2018

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The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes

21 January 2018

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Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

21 January 2018

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Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors: a potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis

21 January 2018

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Nuclear respiratory factors 1 and 2 utilize similar glutamine-containing clusters of hydrophobic residues to activate transcription

21 January 2018

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Nuclear control of respiratory chain expression in mammalian cells

21 January 2018

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Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

21 January 2018

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Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1.

21 January 2018

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FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance

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Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1.

21 January 2018

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The physiological significance of mitochondrial proton leak in animal cells and tissues

21 January 2018

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Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia

21 January 2018

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21 January 2018

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21 January 2018

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The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts

21 January 2018

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Linkage Between Markers in the Vicinity of the Uncoupling Protein 2 Gene and Resting Metabolic Rate in Humans

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21 January 2018

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Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

21 January 2018

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Energy metabolism in uncoupling protein 3 gene knockout mice

21 January 2018

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In vivo effects of uncoupling protein-3 gene disruption on mitochondrial energy metabolism

21 January 2018

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Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean

21 January 2018

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Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

21 January 2018

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Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice

21 January 2018

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Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat

21 January 2018

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Absence of perilipin results in leanness and reverses obesity in Lepr(db/db) mice

21 January 2018

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Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity

21 January 2018

1 reference

Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2

21 January 2018

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Life without white fat: a transgenic mouse

21 January 2018

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21 January 2018

Lipoatrophy revisited

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PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance

21 January 2018

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Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency

21 January 2018

1 reference

Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension

21 January 2018

1 reference

In vivo modulation of Hmgic reduces obesity

21 January 2018

1 reference

Effects of GH and/or sex steroid administration on abdominal subcutaneous and visceral fat in healthy aged women and men.

21 January 2018

1 reference

A transgenic model of visceral obesity and the metabolic syndrome

21 January 2018

1 reference

CELL BIOLOGY: Enhanced: Chewing the Fat--ACC and Energy Balance

21 January 2018

1 reference

Positional cloning of the mouse obese gene and its human homologue

21 January 2018

1 reference

Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y

21 January 2018

1 reference

Orlistat, a lipase inhibitor, for weight maintenance after conventional dieting: a 1-y study

21 January 2018

1 reference

Positional cloning of the mouse obese gene and its human homologue

31 March 2020

1 reference

Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

31 March 2020

1 reference

A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse

31 March 2020

1 reference

Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein

31 March 2020

1 reference

Cholecystokinin decreases food intake in rats.

31 March 2020

1 reference

Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats

31 March 2020

1 reference

Towards cannabinoid drugs--revisited.

31 March 2020

1 reference

Anandamide induces overeating: mediation by central cannabinoid (CB1) receptors

31 March 2020

1 reference

Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold

31 March 2020

1 reference

Regulation of adipose cell number in man

31 March 2020

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Failure of adipocyte differentiation causes type II diabetes mellitus?

31 March 2020

1 reference

Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes

31 March 2020

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Afferent signals regulating food intake

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD770

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Dimensions Publication ID

4 August 2017

1025071082

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