Methionine residue 35 is critical for the oxidative stress and neurotoxic properties of Alzheimer's amyloid beta-peptide 1-42. (Q34750595)

4 August 2017

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title

Methionine residue 35 is critical for the oxidative stress and neurotoxic properties of Alzheimer's amyloid beta-peptide 1-42. (English)

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4 August 2017

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1

D Allan Butterfield

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4 August 2017

Jaroslaw Kanski

2

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4 August 2017

1 July 2002

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4 August 2017

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4 August 2017

23

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4 August 2017

7

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4 August 2017

1299-1309

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Enhancement of beta-amyloid peptide A beta(1-40)-mediated neurotoxicity by glutamine synthetase.

4 August 2017

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Glutamine synthetase-induced enhancement of beta-amyloid peptide A beta (1-40) neurotoxicity accompanied by abrogation of fibril formation and A beta fragmentation

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7 January 2021

Oxidative modification of glutamine synthetase by amyloid beta peptide.

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7 January 2021

Oxidative modification of creatine kinase BB in Alzheimer's disease brain.

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7 January 2021

Protein oxidation in the brain in Alzheimer's disease

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7 January 2021

Bcl-2 protects isolated plasma and mitochondrial membranes against lipid peroxidation induced by hydrogen peroxide and amyloid beta-peptide.

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7 January 2021

beta-Amyloid-associated free radical oxidative stress and neurotoxicity: implications for Alzheimer's disease

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7 January 2021

beta-Amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: implications to Alzheimer's disease.

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7 January 2021

Oxidatively induced structural alteration of glutamine synthetase assessed by analysis of spin label incorporation kinetics: relevance to Alzheimer's disease.

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7 January 2021

NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: the role of oxidant/antioxidant balance.

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7 January 2021

Solution structure of amyloid beta-peptide(1-40) in a water-micelle environment. Is the membrane-spanning domain where we think it is?

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7 January 2021

Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits

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Melatonin prevents beta-amyloid-induced lipid peroxidation

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7 January 2021

In vivo aggregation of beta-amyloid peptide variants

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7 January 2021

Increased nuclear DNA oxidation in the brain in Alzheimer's disease.

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7 January 2021

Decrease in peptide methionine sulfoxide reductase in Alzheimer's disease brain.

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7 January 2021

Low concentrations of estradiol reduce beta-amyloid (25-35)-induced toxicity, lipid peroxidation and glucose utilization in human SK-N-SH neuroblastoma cells.

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7 January 2021

Brain membrane fluidity and lipid peroxidation in Alzheimer's disease.

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7 January 2021

Direct evidence of oxidative injury produced by the Alzheimer's beta-amyloid peptide (1-40) in cultured hippocampal neurons

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7 January 2021

Amyloid beta peptide (25-35) inhibits Na+-dependent glutamate uptake in rat hippocampal astrocyte cultures

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7 January 2021

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease

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7 January 2021

Brain regional correspondence between Alzheimer's disease histopathology and biomarkers of protein oxidation.

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7 January 2021

Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

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7 January 2021

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

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7 January 2021

Role of glycine-33 and methionine-35 in Alzheimer's amyloid beta-peptide 1-42-associated oxidative stress and neurotoxicity

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7 January 2021

Advances in Alzheimer's disease

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7 January 2021

4-Hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes.

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7 January 2021

Vitamin E protects against Alzheimer's amyloid peptide (25-35)-induced changes in neocortical synaptosomal membrane lipid structure and composition.

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7 January 2021

Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis.

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7 January 2021

NMDA-dependent superoxide production and neurotoxicity.

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7 January 2021

Vulnerability of synaptosomes from apoE knock-out mice to structural and oxidative modifications induced by A beta(1-40): implications for Alzheimer's disease.

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7 January 2021

The glial glutamate transporter, GLT-1, is oxidatively modified by 4-hydroxy-2-nonenal in the Alzheimer's disease brain: the role of Abeta1-42.

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7 January 2021

Methionine residues as endogenous antioxidants in proteins

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7 January 2021

Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34.

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7 January 2021

Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease.

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7 January 2021

Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer's disease.

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7 January 2021

An assessment of oxidative damage to proteins, lipids, and DNA in brain from patients with Alzheimer's disease.

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Increased peroxidation and reduced antioxidant enzyme activity in Alzheimer's disease.

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7 January 2021

Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death.

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7 January 2021

Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation

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Characterization of 8-epiprostaglandin F2alpha as a marker of amyloid beta-peptide-induced oxidative damage.

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7 January 2021

Oxidative stress hypothesis in Alzheimer's disease

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7 January 2021

Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease.

1 reference

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7 January 2021

Disruption of brain cell ion homeostasis in Alzheimer's disease by oxy radicals, and signaling pathways that protect therefrom

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Increased susceptibility of Alzheimer's disease temporal cortex to oxygen free radical-mediated processes.

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7 January 2021

Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain.

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7 January 2021

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

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7 January 2021

4-hydroxy-2-nonenal pyrrole adducts in human neurodegenerative disease.

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7 January 2021

Cerebrospinal fluid F2-isoprostane levels are increased in Alzheimer's disease.

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7 January 2021

In-vivo glutathione elevation protects against hydroxyl free radical-induced protein oxidation in rat brain

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Glutathione elevation and its protective role in acrolein-induced protein damage in synaptosomal membranes: relevance to brain lipid peroxidation in neurodegenerative disease

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7 January 2021

Is Oxidative Damage by β-Amyloid and Prion Peptides Mediated by Hydrogen Atom Transfer from Glycine α-Carbon to Methionine Sulfur within β-Sheets?

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7 January 2021

The toxicity of the Alzheimer's beta-amyloid peptide correlates with a distinct fiber morphology.

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7 January 2021

Amyloid beta-protein and the genetics of Alzheimer's disease

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7 January 2021

Diastereoselective reduction of protein-bound methionine sulfoxide by methionine sulfoxide reductase.

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7 January 2021

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease

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Advanced Maillard reaction end products are associated with Alzheimer disease pathology

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Widespread peroxynitrite-mediated damage in Alzheimer's disease.

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Cytochemical demonstration of oxidative damage in Alzheimer disease by immunochemical enhancement of the carbonyl reaction with 2,4-dinitrophenylhydrazine.

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7 January 2021

Autopsy samples of Alzheimer's cortex show increased peroxidation in vitro

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7 January 2021

The free radical antioxidant vitamin E protects cortical synaptosomal membranes from amyloid beta-peptide(25-35) toxicity but not from hydroxynonenal toxicity: relevance to the free radical hypothesis of Alzheimer's disease.

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7 January 2021

Methionine residue 35 is important in amyloid beta-peptide-associated free radical oxidative stress.

1 reference

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7 January 2021

Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity

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Different mechanisms of oxidative stress and neurotoxicity for Alzheimer's A beta(1--42) and A beta(25--35).

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Advanced glycation end products contribute to amyloidosis in Alzheimer disease

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Oxidation of methionyl residues in proteins: tools, targets, and reversal

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The antioxidant vitamin E modulates amyloid beta-peptide-induced creatine kinase activity inhibition and increased protein oxidation: implications for the free radical hypothesis of Alzheimer's disease.

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Alzheimer's amyloid beta-peptide associated free radicals increase rat embryonic neuronal polyamine uptake and ornithine decarboxylase activity: protective effect of vitamin E.

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Role of spermine in amyloid beta-peptide-associated free radical-induced neurotoxicity

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Substitution of isoleucine-31 by helical-breaking proline abolishes oxidative stress and neurotoxic properties of Alzheimer's amyloid beta-peptide

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7 January 2021

The hydrophobic environment of Met35 of Alzheimer's Abeta(1-42) is important for the neurotoxic and oxidative properties of the peptide.

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7 January 2021

Lipid peroxidation and protein oxidation in Alzheimer's disease brain: potential causes and consequences involving amyloid beta-peptide-associated free radical oxidative stress

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Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide

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7 January 2021

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Identifiers

DOI

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4 August 2017

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PubMed ID

12128086