Characterization of a tumor-associated activating mutation of the p110β PI 3-kinase. (Q34755265)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23734178%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

title

Characterization of a tumor-associated activating mutation of the p110β PI 3-kinase (English)

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2 March 2020

1

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2 March 2020

author name string

Bassem D Khalil

2

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2 March 2020

Haiyan Wu

3

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2 March 2020

Aliaksei Shymanets

4

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2 March 2020

Bernd Nürnberg

5

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2 March 2020

Jonathan M Backer

6

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2 March 2020

language of work or name

English

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publication date

29 May 2013

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2 March 2020

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2 March 2020

volume

8

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2 March 2020

issue

5

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2 March 2020

page(s)

e63833

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Creative Commons Attribution 4.0 International

2 March 2020

copyright license

start time

29 May 2013

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3667187/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness

1 reference

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Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS).

7 July 2018

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The p101 subunit of PI3Kγ restores activation by Gβ mutants deficient in stimulating p110γ.

7 July 2018

1 reference

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Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110α

7 July 2018

1 reference

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Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism

7 July 2018

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A biochemical mechanism for the oncogenic potential of the p110β catalytic subunit of phosphoinositide 3-kinase

7 July 2018

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Diverse somatic mutation patterns and pathway alterations in human cancers

7 July 2018

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Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation

7 July 2018

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A frequent kinase domain mutation that changes the interaction between PI3K and the membrane

7 July 2018

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Targeting PI3K signalling in cancer: opportunities, challenges and limitations

7 July 2018

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Gbetagamma-copurified lipid kinase impurity from Sf9 cells

7 July 2018

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PI3K pathway alterations in cancer: variations on a theme

7 July 2018

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Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms

7 July 2018

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Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase

7 July 2018

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Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma

7 July 2018

1 reference

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A specific function for phosphatidylinositol 3-kinase alpha (p85alpha-p110alpha) in cell survival and for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in de novo DNA synthesis of human colon carcinoma cells

7 July 2018

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Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation

7 July 2018

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Mechanism of constitutive phosphoinositide 3-kinase activation by oncogenic mutants of the p85 regulatory subunit

7 July 2018

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Crossref

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Gbetagamma stimulates phosphoinositide 3-kinase-gamma by direct interaction with two domains of the catalytic p110 subunit.

21 January 2018

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Functional differences between two classes of oncogenic mutation in the PIK3CA gene

21 January 2018

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Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3'-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas.

21 January 2018

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10.1371/JOURNAL.PONE.0063833

26 October 2018

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23734178%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

0 references

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2 March 2020

PubMed publication ID

23734178

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23734178%20AND%20SRC:MED&resulttype=core&format=json