The p101 subunit of PI3Kγ restores activation by Gβ mutants deficient in stimulating p110γ. (Q42015385)

15 October 2017

The p101 subunit of PI3Kγ restores activation by Gβ mutants deficient in stimulating p110γ. (English)

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15 October 2017

Aliaksei Shymanets

1

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15 October 2017

Mohammad R Ahmadian

2

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15 October 2017

Katja T Kössmeier

3

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15 October 2017

Reinhard Wetzker

4

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15 October 2017

Christian Harteneck

5

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15 October 2017

Bernd Nürnberg

6

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15 October 2017

language of work or name

English

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publication date

1 February 2012

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15 October 2017

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15 October 2017

441

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15 October 2017

851-858

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15 October 2017

3

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Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase

15 October 2017

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Fine tuning the immune response with PI3K.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

The catalytic PI3K isoforms p110gamma and p110delta contribute to B cell development and maintenance, transformation, and proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Phosphoinositide signalling in cancer: beyond PI3K and PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

PI3K kinase and scaffold functions in heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Key role of phosphoinositide 3-kinase class IB in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

The emerging mechanisms of isoform-specific PI3K signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Mechanisms regulating phosphoinositide 3-kinase signalling in insulin-sensitive tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

PI3K inhibition in inflammation: Toward tailored therapies for specific diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Gbetagamma stimulates phosphoinositide 3-kinase-gamma by direct interaction with two domains of the catalytic p110 subunit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Assigning functional domains within the p101 regulatory subunit of phosphoinositide 3-kinase gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Signalling through Class I PI3Ks in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

PI3Kgamma adaptor subunits define coupling to degranulation and cell motility by distinct PtdIns(3,4,5)P3 pools in mast cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Pasteurella multocida toxin activates Gbetagamma dimers of heterotrimeric G proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Regulation of the p85/p110alpha phosphatidylinositol 3'-kinase. Distinct roles for the n-terminal and c-terminal SH2 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Mechanism of constitutive phosphoinositide 3-kinase activation by oncogenic mutants of the p85 regulatory subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Form and flexibility in phosphoinositide 3-kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110alpha and are disrupted in oncogenic p85 mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

A biochemical mechanism for the oncogenic potential of the p110beta catalytic subunit of phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Gbeta 5gamma 2 is a highly selective activator of phospholipid-dependent enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Signal amplification between Gbetagamma release and PI3Kgamma-mediated PI(3,4,5)P3 formation monitored by a fluorescent Gbetagamma biosensor protein and repetitive two component total internal reflection/fluorescence redistribution after photobleach

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

The 2.0 A crystal structure of a heterotrimeric G protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Molecular basis for interactions of G protein betagamma subunits with effectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

G protein betagamma subunits as targets for small molecule therapeutic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Gbetagamma-copurified lipid kinase impurity from Sf9 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms beta and gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

G protein beta gamma subunit: physical and chemical characterization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Sites for Galpha binding on the G protein beta subunit overlap with sites for regulation of phospholipase Cbeta and adenylyl cyclase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Sites important for PLCbeta2 activation by the G protein betagamma subunit map to the sides of the beta propeller structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Analysis of class I phosphoinositide 3-kinase autophosphorylation sites by mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

G protein mechanisms: insights from structural analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

Structural and molecular characterization of a preferred protein interaction surface on G protein beta gamma subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

PI3K p110β: More Tightly Controlled or Constitutively Active?

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111664

21 January 2018

Identifiers

DOI

10.1042/BJ20111664

1 reference

15 October 2017

1 reference