Clinical pharmacology and pharmacogenetics of thiopurines (Q34782066)

4 August 2017

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title

Clinical pharmacology and pharmacogenetics of thiopurines (English)

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4 August 2017

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Srikumar Sahasranaman

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1

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4 August 2017

Danny Howard

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2

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4 August 2017

Sandip Roy

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3

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4 August 2017

publication date

28 May 2008

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European Journal of Clinical Pharmacology

4 August 2017

published in

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4 August 2017

volume

64

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4 August 2017

issue

8

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4 August 2017

page(s)

753-767

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Azathioprine metabolism: pharmacokinetics of 6-mercaptopurine, 6-thiouric acid and 6-thioguanine nucleotides in renal transplant patients

4 August 2017

cites work

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12 December 2020

Epstein-Barr virus-positive lymphoma in patients with inflammatory bowel disease treated with azathioprine or 6-mercaptopurine

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12 December 2020

Lamina propria T cells in Crohn's disease and other gastrointestinal inflammation show defective CD2 pathway-induced apoptosis

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12 December 2020

Influence of the variable number of tandem repeats located in the promoter region of the thiopurine methyltransferase gene on enzymatic activity

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12 December 2020

No induction of thiopurine methyltransferase during thiopurine treatment in inflammatory bowel disease

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12 December 2020

Detection of known and new mutations in the thiopurine S-methyltransferase gene by single-strand conformation polymorphism analysis

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12 December 2020

Long-term results of TPMT activity monitoring in azathioprine-treated renal allograft recipients

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12 December 2020

Inflammatory bowel disease is not associated with an increased risk of lymphoma

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12 December 2020

Identification of two novel sequence variants affecting thiopurine methyltransferase enzyme activity.

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12 December 2020

Human erythrocyte thiopurine methyltransferase: radiochemical microassay and biochemical properties

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12 December 2020

The successful treatment of autoimmune hepatitis with 6-mercaptopurine after failure with azathioprine

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12 December 2020

Substitution of oral and intravenous thioguanine for mercaptopurine in a treatment regimen for children with standard risk acute lymphoblastic leukemia: a collaborative Children's Oncology Group/National Cancer Institute pilot trial (CCG-1942).

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12 December 2020

Treatment of acute myeloid leukaemia in children.

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12 December 2020

Gene mutation of thiopurine S-methyltransferase in Uygur Chinese

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12 December 2020

The clinical pharmacology of 6-mercaptopurine

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12 December 2020

Human thiopurine methyltransferase pharmacogenetics: gene sequence polymorphisms

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12 December 2020

A role for TNF-alpha and mucosal T helper-1 cytokines in the pathogenesis of Crohn's disease

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12 December 2020

Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase

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12 December 2020

Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience

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12 December 2020

Exposure to thiopurine drugs through breast milk is low based on metabolite concentrations in mother-infant pairs

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12 December 2020

Thiopurine methyltransferase phenotype and genotype in relation to azathioprine therapy in autoimmune hepatitis

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12 December 2020

Enhanced proteasomal degradation of mutant human thiopurine S-methyltransferase (TPMT) in mammalian cells: mechanism for TPMT protein deficiency inherited by TPMT*2, TPMT*3A, TPMT*3B or TPMT*3C

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12 December 2020

Mechanism of angiotensin converting enzyme inhibitor-related anemia in renal transplant recipients

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12 December 2020

Thiopurine S-methyltransferase as a target for drug interactions

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12 December 2020

Non-Hodgkin's lymphoma in children. A comparative study of two modalities of therapy

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12 December 2020

Vaccination of a Patient Receiving Immunosuppressive Therapy for Lymphosarcoma

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12 December 2020

Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia

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12 December 2020

Allelotype frequency of the thiopurine methyltransferase (TPMT) gene in Japanese

1 reference

12 December 2020

In vitro characterization of four novel non-functional variants of the thiopurine S-methyltransferase

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12 December 2020

Pharmacokinetics and metabolism of thiopurines in children with acute lymphoblastic leukemia receiving 6-thioguanine versus 6-mercaptopurine

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12 December 2020

Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity

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12 December 2020

Allelic variants of the thiopurine methyltransferase (TPMT) gene in the Colombian population

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12 December 2020

Inhibition of human thiopurine methyltransferase by furosemide, bendroflumethiazide and trichlormethiazide

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12 December 2020

Molecular analysis of thiopurine S-methyltransferase alleles in South-east Asian populations

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12 December 2020

The importance of thiopurine methyltransferase activity for the use of azathioprine in transplant recipients

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12 December 2020

Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians

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12 December 2020

Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus

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12 December 2020

A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase

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12 December 2020

Thiopurine methyltransferase polymorphisms in a multiracial asian population and children with acute lymphoblastic leukemia

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12 December 2020

Warfarin and azathioprine: an important drug interaction

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12 December 2020

Isolation of a human thiopurine S-methyltransferase (TPMT) complementary DNA with a single nucleotide transition A719G (TPMT*3C) and its association with loss of TPMT protein and catalytic activity in humans.

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12 December 2020

Thiopurine pharmacogenetics: clinical and molecular studies of thiopurine methyltransferase

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12 December 2020

Human thiopurine methyltransferase pharmacogenetics. Kindred with a terminal exon splice junction mutation that results in loss of activity

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12 December 2020

6-Mercaptopurine in the management of inflammatory bowel disease: short- and long-term toxicity

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12 December 2020

Prednisone plus azathioprine treatment in patients with rheumatoid arthritis complicated by vasculitis

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12 December 2020

Azathioprine as a treatment for severe atopic eczema in children with a partial thiopurine methyl transferase (TPMT) deficiency

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12 December 2020

6-Methylthioguanylic acid, a metabolite of 6-thioguanine

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12 December 2020

Pulse dosing of thioguanine in recalcitrant psoriasis

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12 December 2020

Risk of lymphoma in inflammatory bowel disease

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12 December 2020

Genetic polymorphism of thiopurine S-methyltransferase in Argentina

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12 December 2020

Ulcerative colitis practice guidelines in adults. American College of Gastroenterology, Practice Parameters Committee.

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12 December 2020

6-Thioguanine in children with acute lymphoblastic leukaemia: influence of food on parent drug pharmacokinetics and 6-thioguanine nucleotide concentrations

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12 December 2020

Inhibition of phosphoribosyl pyrophosphate amidotransferase from Ehrlich ascites-tumour cells by thiopurine nucleotides

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12 December 2020

Genetic determinants of the thiopurine methyltransferase intermediate activity phenotype in British Asians and Caucasians

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12 December 2020

Characterization of three new VNTR alleles in the promoter region of the TPMT gene

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12 December 2020

Review article: thiopurines in inflammatory bowel disease

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12 December 2020

Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms

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12 December 2020

Olsalazine and 6-mercaptopurine-related bone marrow suppression: a possible drug-drug interaction

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12 December 2020

The role of leukopenia in the 6-mercaptopurine-induced remission of refractory Crohn's disease

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12 December 2020

Controlled trial of azathioprine in chronic ulcerative colitis

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12 December 2020

Genotype and allele frequencies of TPMT, NAT2, GST, SULT1A1 and MDR-1 in the Egyptian population

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12 December 2020

Detection of one single mutation predicts thiopurine S-methyltransferase activity in a population of Saami in northern Norway

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12 December 2020

The pharmacokinetic effect of discontinuation of mesalazine on mercaptopurine metabolite levels in inflammatory bowel disease patients

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12 December 2020

Optimizing immunomodulator therapy for inflammatory bowel disease

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12 December 2020

Azathioprine and 6-mercaptopurine in Crohn disease. A meta-analysis

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12 December 2020

CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes

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12 December 2020

Genotype-phenotype correlation for thiopurine S-methyltransferase in healthy Italian subjects

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12 December 2020

Thiopurine methyltransferase alleles in British and Ghanaian populations

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12 December 2020

6-thioguanine-buried alive?

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12 December 2020

Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia

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12 December 2020

Renal transplantation, past, present and future

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12 December 2020

Efficacy of daunorubicin in the therapy of adult acute lymphocytic leukemia: a prospective randomized trial by cancer and leukemia group B

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12 December 2020

Safety of azathioprine and 6-mercaptopurine in pediatric patients with inflammatory bowel disease

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12 December 2020

Selective inhibition of inflammatory gene expression in activated T lymphocytes: a mechanism of immune suppression by thiopurines

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12 December 2020

Lack of effect of intravenous administration on time to respond to azathioprine for steroid-treated Crohn's disease

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12 December 2020

Diminished anticoagulant effects of warfarin with concomitant mercaptopurine therapy

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12 December 2020

Transport and metabolism of 6-thioguanine and 6-mercaptopurine in mouse small intestine

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12 December 2020

6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease.

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12 December 2020

Hazard of combining allopurinol and thiopurine.

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12 December 2020

Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine

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12 December 2020

Symposium on immunosuppressive drugs. Biochemistry and pharmacology of purine analogues

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12 December 2020

The frequency and distribution of thiopurine methyltransferase alleles in Caucasian and Asian populations

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12 December 2020

Frequency distribution of thiopurine S-methyltransferase alleles in a polish population

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12 December 2020

Identification of 6-mercaptopurine riboside in patients receiving 6-mercaptopurine as a prolonged intravenous infusion

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12 December 2020

High cure rate with a moderately intensive treatment regimen in non-high-risk childhood acute lymphoblastic leukemia. Results of protocol ALL VI from the Dutch Childhood Leukemia Study Group

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12 December 2020

Drug interaction between infliximab and azathioprine in patients with Crohn's disease.

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12 December 2020

Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease

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12 December 2020

Treatment of Crohn's disease with 6-mercaptopurine. A long-term, randomized, double-blind study

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12 December 2020

Thiopurine methyltransferase activity in American white subjects and black subjects

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12 December 2020

A comparison of red blood cell thiopurine metabolites in children with acute lymphoblastic leukemia who received oral mercaptopurine twice daily or once daily: a Pediatric Oncology Group study (now The Children's Oncology Group).

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12 December 2020

Characterization of a variable number tandem repeat region in the thiopurine S-methyltransferase gene promoter

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12 December 2020

Phase II evaluation and plasma pharmacokinetics of high-dose intravenous 6-thioguanine in patients with colorectal carcinoma

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12 December 2020

Sulphasalazine inhibition of thiopurine methyltransferase: possible mechanism for interaction with 6‐mercaptopurine and azathioprine

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12 December 2020

Organic anion transporter 3 is involved in the brain-to-blood efflux transport of thiopurine nucleobase analogs

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12 December 2020

Pharmacogenetics as a molecular basis for individualized drug therapy: the thiopurine S-methyltransferase paradigm

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12 December 2020

Thiopurine methyltransferase. Aromatic thiol substrates and inhibition by benzoic acid derivatives.

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12 December 2020

Intravenous azathioprine in severe ulcerative colitis: a pilot study.

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12 December 2020

Pyrosequencing of TPMT alleles in a general Swedish population and in patients with inflammatory bowel disease.

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12 December 2020

Interleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa

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12 December 2020

Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): mechanisms for the genetic polymorphism of TPMT activity

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12 December 2020

RELATIONSHIP BETWEEN METABOLIC FATES AND ANTITUMOR ACTIVITIES OF THIOPURINES

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12 December 2020

Allele frequency of inosine triphosphate pyrophosphatase gene polymorphisms in a Japanese population

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12 December 2020

Thiopurine methyltransferase polymorphic tandem repeat: genotype-phenotype correlation analysis

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12 December 2020

The fate of 6-mercaptopurine in man

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12 December 2020

Pharmacogenetics of thiopurine S-methyltransferase and thiopurine therapy

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12 December 2020

Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia

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12 December 2020

Thiopurine S-methyltransferase genetic polymorphism in the Thai population

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12 December 2020

Distribution of ITPA P32T alleles in multiple world populations

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12 December 2020

Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants

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12 December 2020

Drugs of choice for cancer chemotherapy

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12 December 2020

Ethnic differences in thiopurine methyltransferase pharmacogenetics: evidence for allele specificity in Caucasian and Kenyan individuals.

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12 December 2020

Phenotypic and Genotypic Analysis of Thiopurine S-Methyltransferase Polymorphism in the Bulgarian Population

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12 December 2020

Interethnic difference in thiopurine methyltransferase activity

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12 December 2020

Human kidney thiopurine methyltransferase. Purification and biochemical properties.

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12 December 2020

Leucopenia resulting from a drug interaction between azathioprine or 6-mercaptopurine and mesalamine, sulphasalazine, or balsalazide

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12 December 2020

Thiopurine methyltransferase: should it be measured before commencing thiopurine drug therapy?

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12 December 2020

Thioguanine administered as a continuous intravenous infusion to pediatric patients is metabolized to the novel metabolite 8-hydroxy-thioguanine

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12 December 2020

Phenotype and genotype for thiopurine methyltransferase activity in the French Caucasian population: impact of age.

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12 December 2020

Lack of association between the ITPA 94C>A polymorphism and adverse effects from azathioprine

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12 December 2020

Phenotyping and genotyping study of thiopurine S-methyltransferase in healthy Chinese children: a comparison of Han and Yao ethnic groups

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12 December 2020

Actions of purine analogs: enzyme specificity studies as a basis for interpretation and design

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12 December 2020

Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency.

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12 December 2020

A comparison of the specificities of xanthine oxidase and aldehyde oxidase.

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12 December 2020

Azathioprine therapy for patients with systemic lupus erythematosus

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12 December 2020

Thioguanine used in maintenance therapy of chronic myeloid leukaemia causes non-cirrhotic portal hypertension. Results from MRC CML. II. Trial comparing busulphan with busulphan and thioguanine

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12 December 2020

The purine path to chemotherapy

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12 December 2020

Polymorphism of the thiopurine S-methyltransferase gene in African-Americans

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12 December 2020

Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient.

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12 December 2020

Anemia in renal transplant recipients caused by concomitant therapy with azathioprine and angiotensin-converting enzyme inhibitors

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12 December 2020

Azathioprine and anti-TNF alpha therapies in Crohn's disease: a review of pharmacology, clinical efficacy and safety

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12 December 2020

The treatment of chronic ulcerative colitis with 6-mercaptopurine

1 reference

12 December 2020

Thiopurine methyltransferase polymorphisms in a Brazilian population.

1 reference

12 December 2020

Inhibition of first-pass metabolism in cancer chemotherapy: interaction of 6-mercaptopurine and allopurinol

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12 December 2020

Thiopurine treatment in inflammatory bowel disease: clinical pharmacology and implication of pharmacogenetically guided dosing

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12 December 2020

Thiopurine-methyl-transferase activity to assess azathioprine myelotoxicity in renal transplant recipients

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12 December 2020

Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase).

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12 December 2020

Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance

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12 December 2020

Management of Crohn's disease in adults

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12 December 2020

Role of postreplicative DNA mismatch repair in the cytotoxic action of thioguanine.

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12 December 2020

The thiopurine S-methyltransferase gene locus -- implications for clinical pharmacogenomics

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12 December 2020

A pediatric phase I trial and pharmacokinetic study of thioguanine administered by continuous i.v. infusion

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12 December 2020

Non-Hodgkin's lymphoma in children.A progress report on the original patients treated with the LSA2-L2 protocol

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12 December 2020

Breast-feeding during maternal use of azathioprine

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12 December 2020

Variable mercaptopurine metabolism and treatment outcome in childhood lymphoblastic leukemia

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12 December 2020

Delayed cytotoxicity of 6-mercaptopurine is compatible with mitotic death caused by DNA damage due to incorporation of 6-thioguanine into DNA as 6-thioguanine nucleotide

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12 December 2020

10.1007/S00228-008-0478-6

Identifiers

DOI

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Dimensions Publication ID

4 August 2017

1015605568

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