KSR1 is overexpressed in endometrial carcinoma and regulates proliferation and TRAIL-induced apoptosis by modulating FLIP levels (Q34805471)

4 August 2017

title

KSR1 is overexpressed in endometrial carcinoma and regulates proliferation and TRAIL-induced apoptosis by modulating FLIP levels (English)

1 reference

4 August 2017

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endometrial carcinoma

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Mario Encinas

10

0 references

Maria Santacana

object named as

Maria Santacana

6

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Gema Moreno-Bueno

object named as

Gema Moreno-Bueno

11

0 references

Xavier Matias-Guiu Guia

14

object named as

Xavier Matias-Guiu

1 reference

4 August 2017

David Llobet

1

1 reference

4 August 2017

Nuria Eritja

2

1 reference

4 August 2017

Monica Domingo

3

1 reference

4 August 2017

Laura Bergada

4

1 reference

4 August 2017

Cristina Mirantes

5

1 reference

4 August 2017

Judit Pallares

7

1 reference

4 August 2017

Anna Macià

8

1 reference

4 August 2017

Andree Yeramian

9

1 reference

4 August 2017

Jose Palacios

12

1 reference

4 August 2017

Robert E Lewis

13

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4 August 2017

Xavi Dolcet

15

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4 August 2017

language of work or name

English

0 references

publication date

1 April 2011

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The American Journal of Pathology

4 August 2017

published in

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4 August 2017

volume

178

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4 August 2017

issue

4

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4 August 2017

page(s)

1529-1543

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CK2beta is expressed in endometrial carcinoma and has a role in apoptosis resistance and cell proliferation.

4 August 2017

cites work

1 reference

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The TRAIL apoptotic pathway in cancer onset, progression and therapy

8 July 2018

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CK2 controls TRAIL and Fas sensitivity by regulating FLIP levels in endometrial carcinoma cells.

8 July 2018

1 reference

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Targeting TRAIL agonistic receptors for cancer therapy.

8 July 2018

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The promise of TRAIL--potential and risks of a novel anticancer therapy

8 July 2018

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TRAIL signalling: decisions between life and death.

8 July 2018

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CK2 Is a component of the KSR1 scaffold complex that contributes to Raf kinase activation

8 July 2018

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8 July 2018

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TRAIL receptor-mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver damage and lethality.

8 July 2018

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8 July 2018

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8 July 2018

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Proteasome inhibitors induce death but activate NF-kappaB on endometrial carcinoma cell lines and primary culture explants

8 July 2018

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8 July 2018

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The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover

8 July 2018

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Coordinating ERK/MAPK signalling through scaffolds and inhibitors

8 July 2018

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mTOR controls FLIPS translation and TRAIL sensitivity in glioblastoma multiforme cells

8 July 2018

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Expression of kinase suppressor of Ras1 enhances cisplatin-induced extracellular signal-regulated kinase activation and cisplatin sensitivity

8 July 2018

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Rapid turnover of c-FLIPshort is determined by its unique C-terminal tail

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078440

FLIP is frequently expressed in endometrial carcinoma and has a role in resistance to TRAIL-induced apoptosis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078440

NF-kB in development and progression of human cancer

8 July 2018

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Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation

8 July 2018

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Inflammatory bowel disease reveals the kinase activity of KSR1

8 July 2018

1 reference

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Persistent c-FLIP(L) expression is necessary and sufficient to maintain resistance to tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in prostate cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078440

FLIP overexpression inhibits death receptor-induced apoptosis in malignant mesothelial cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078440

The molecular scaffold KSR1 regulates the proliferative and oncogenic potential of cells

8 July 2018

1 reference

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Expression of the cellular FLICE-inhibitory protein (c-FLIP) protects Hodgkin's lymphoma cells from autonomous Fas-mediated death

8 July 2018

1 reference

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N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway

8 July 2018

1 reference

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Pharmacologic inactivation of kinase suppressor of ras-1 abrogates Ras-mediated pancreatic cancer

8 July 2018

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Apo2L/TRAIL and its death and decoy receptors

8 July 2018

1 reference

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Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.

8 July 2018

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Protein kinase CK2: structure, regulation and role in cellular decisions of life and death

8 July 2018

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The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex

8 July 2018

1 reference

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Joining the cell survival squad: an emerging role for protein kinase CK2.

8 July 2018

1 reference

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Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo

8 July 2018

1 reference

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An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis

8 July 2018

1 reference

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KSR is a scaffold required for activation of the ERK/MAPK module

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078440

Protein kinase CK2 signal in neoplasia

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078440

KSR: a MAPK scaffold of the Ras pathway?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078440

Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078440

Mammalian MAP kinase signalling cascades

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078440

Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078440

FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078440

TRAIL receptor-2 signals apoptosis through FADD and caspase-8

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078440

Caspase-induced inactivation of the anti-apoptotic TRAF1 during Fas ligand-mediated apoptosis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078440

Safety and antitumor activity of recombinant soluble Apo2 ligand

8 July 2018

1 reference

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Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.

8 July 2018

1 reference

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TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078440

Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078440

KSR modulates signal propagation within the MAPK cascade

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078440

The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078440

The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078440

KSR, a novel protein kinase required for RAS signal transduction

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078440

Protein kinases. 4. Protein kinase CK2: an enzyme with multiple substrates and a puzzling regulation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078440

Isolation, sequencing, and disruption of the yeast CKA2 gene: casein kinase II is essential for viability in Saccharomyces cerevisiae

8 July 2018

1 reference

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Molecular cloning of casein kinase II alpha subunit from Dictyostelium discoideum and its expression in the life cycle

8 July 2018

1 reference

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The multikinase inhibitor Sorafenib induces apoptosis and sensitises endometrial cancer cells to TRAIL by different mechanisms.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078440

KSR1 is required for cell cycle reinitiation following DNA damage

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078440

Promoter hypermethylation and reduced expression of RASSF1A are frequent molecular alterations of endometrial carcinoma.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078440

The multikinase inhibitor sorafenib potentiates TRAIL lethality in human leukemia cells in association with Mcl-1 and cFLIPL down-regulation

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078440

PIK3CA gene mutations in endometrial carcinoma: correlation with PTEN and K-RAS alterations.

26 October 2018

1 reference

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Translational regulation of TRAIL sensitivity.

26 October 2018

1 reference

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Survivin expression in endometrial carcinoma: a tissue microarray study with correlation with PTEN and STAT-3.

26 October 2018

1 reference

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c-FLIP expression in bladder urothelial carcinomas: its role in resistance to Fas-mediated apoptosis and clinicopathologic correlations

26 October 2018

1 reference

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The kinase activity of kinase suppressor of Ras1 (KSR1) is independent of bound MEK.

26 October 2018

1 reference

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Differential gene expression profile in endometrioid and nonendometrioid endometrial carcinoma: STK15 is frequently overexpressed and amplified in nonendometrioid carcinomas.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078440

Deficiency of kinase suppressor of Ras1 prevents oncogenic ras signaling in mice

26 October 2018

1 reference

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Increased expression of FLIP, an inhibitor of Fas‐mediated apoptosis, in stomach cancer

26 October 2018

1 reference

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Kinase suppressor of Ras signals through Thr269 of c-Raf-1.

26 October 2018

1 reference

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Kinase suppressor of Ras inhibits the activation of extracellular ligand-regulated (ERK) mitogen-activated protein (MAP) kinase by growth factors, activated Ras, and Ras effectors

26 October 2018

1 reference

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Phosphorylation regulates KSR1 stability, ERK activation, and cell proliferation

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21435442

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

K-ras mutations in endometrial carcinomas with microsatellite instability

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21435442

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.AJPATH.2010.12.041

1 reference

4 August 2017

1 reference

4 August 2017

1 reference