Mechanisms of tumour invasion and metastasis: emerging targets for therapy (Q34837655)

4 August 2017

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title

Mechanisms of tumour invasion and metastasis: emerging targets for therapy (English)

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4 August 2017

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John T Price

1

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4 August 2017

Erik W Thompson

series ordinal

2

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4 August 2017

language of work or name

English

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publication date

1 April 2002

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Expert Opinion on Therapeutic Targets

4 August 2017

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4 August 2017

6

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4 August 2017

2

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4 August 2017

217-233

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The biochemistry of cancer dissemination

4 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Cancer invasion and metastasis: positive and negative regulatory elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Supramolecular assembly of basement membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

The influence of the microenvironment on the malignant phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

The microenvironment of the tumour-host interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Angiogenesis and tumor metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

The multiple roles of tumour stroma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Tumour dormancy: findings and hypotheses from clinical research on breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Integrins: versatility, modulation, and signaling in cell adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Integrin cell adhesion receptors and the concept of agonism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Integrins and GTPases in tumour cell growth, motility and invasion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

21 January 2018

Integrins and anoikis

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Integrins and vascular extracellular matrix assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Role of integrins in angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Pro-collagenase-1 (matrix metalloproteinase-1) binds the alpha(2)beta(1) integrin upon release from keratinocytes migrating on type I collagen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Re-expression of the alpha 2 beta 1 integrin abrogates the malignant phenotype of breast carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Integrin alpha6beta1 role in metastatic behavior of human pancreatic carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

The integrin, alpha6beta1, is necessary for the matrix-dependent activation of FAK and MAP kinase and the migration of human hepatocarcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

The integrin alpha6beta4 functions in carcinoma cell migration on laminin-1 by mediating the formation and stabilization of actin-containing motility structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

AlphaVbeta6 integrin promotes invasion of squamous carcinoma cells through up-regulation of matrix metalloproteinase-9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Transforming growth factor-beta and breast cancer: Tumor promoting effects of transforming growth factor-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Role of transforming growth factor beta in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Identification and in vivo efficacy of small-molecule antagonists of integrin alphavbeta3 (the vitronectin receptor).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

The role of alpha v-integrins in tumour progression and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

The role of the integrin vitronectin receptor, alpha v beta 3 in melanoma metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Involvement of integrin alpha V gene expression in human melanoma tumorigenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Requirement of the NPXY motif in the integrin beta 3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Small molecule alpha(v) integrin antagonists: novel anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

A pilot trial of Vitaxin, a humanized anti-vitronectin receptor (anti alpha v beta 3) antibody in patients with metastatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

A causal role for E-cadherin in the transition from adenoma to carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell Contacts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Inhibition of invasion of epithelial cells by Tiam1-Rac signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Mutations of the E-cadherin gene in human gynecologic cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Functional interaction of beta-catenin with the transcription factor LEF-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Stabilization of beta-catenin by genetic defects in melanoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

beta-catenin signaling and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Specific protection against breast cancers by cyclin D1 ablation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Correlation of beta-catenin and cyclin D1 expression in colon cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Expression of N-cadherin by human squamous carcinoma cells induces a scattered fibroblastic phenotype with disrupted cell-cell adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

How matrix metalloproteinases regulate cell behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Regulation of cell invasion and morphogenesis in a three-dimensional type I collagen matrix by membrane-type matrix metalloproteinases 1, 2, and 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Critical appraisal of the use of matrix metalloproteinase inhibitors in cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Human endothelial gelatinases and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

The role and regulation of urokinase-type plasminogen activator receptor gene expression in cancer invasion and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Urokinase receptor: a molecular organizer in cellular communication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Prevention of metastasis by inhibition of the urokinase receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Inhibition of colon cancer metastasis by a 3'- end antisense urokinase receptor mRNA in a nude mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Overexpression of ErbB2 in cancer and ErbB2-targeting strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

ErbB2 is necessary for induction of carcinoma cell invasion by ErbB family receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Herceptin (trastuzamab) in advanced breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Platelet-derived growth factor-BB, insulin-like growth factor-I, and phorbol ester activate different signaling pathways for stimulation of vascular smooth muscle cell migration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Cooperative signaling between alpha(6)beta(4) integrin and ErbB-2 receptor is required to promote phosphatidylinositol 3-kinase-dependent invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Rho GTPases: molecular switches that control the organization and dynamics of the actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Rho GTPases are over-expressed in human tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Genomic analysis of metastasis reveals an essential role for RhoC

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Focal adhesion kinase (p125FAK) expression correlates with motility of human melanoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Alterations in the focal adhesion kinase/Src signal transduction pathway correlate with increased migratory capacity of prostate carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Specific Requirement for the p85-p110α Phosphatidylinositol 3-Kinase during Epidermal Growth Factor-stimulated Actin Nucleation in Breast Cancer Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Molecular switches in metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

Broad antitumor and antiangiogenic activities of AG3340, a potent and selective MMP inhibitor undergoing advanced oncology clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.6.2.217

21 January 2018

Identifiers

DOI

10.1517/14728222.6.2.217

1 reference

release_nrsz2yqyp5av3eitb5mlpraxca

4 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/nrsz2yqyp5av3eitb5mlpraxca

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference