Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal. (Q34856951)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18922912%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

title

Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal (English)

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24 December 2019

1 reference

4

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24 December 2019

author name string

Guikai Wu

1

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24 December 2019

Xiao-Long Qiu

2

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24 December 2019

Longen Zhou

3

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24 December 2019

Richard Chamberlin

5

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24 December 2019

Johnson Lau

6

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24 December 2019

Phang-Lang Chen

7

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24 December 2019

Wen-Hwa Lee

8

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24 December 2019

language of work or name

English

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publication date

1 October 2008

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24 December 2019

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24 December 2019

volume

68

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24 December 2019

issue

20

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24 December 2019

page(s)

8393-8399

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A novel role of the chromokinesin Kif4A in DNA damage response

24 December 2019

cites work

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Hice1, a novel microtubule-associated protein required for maintenance of spindle integrity and chromosomal stability in human cells

8 July 2018

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Polo and Aurora kinases: lessons derived from chemical biology

8 July 2018

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Mitotic regulation by NIMA-related kinases

8 July 2018

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The Ndc80 complex: hub of kinetochore activity

8 July 2018

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Development of recombinant adeno-associated virus vectors carrying small interfering RNA (shHec1)-mediated depletion of kinetochore Hec1 protein in tumor cells

8 July 2018

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The conserved KMN network constitutes the core microtubule-binding site of the kinetochore

8 July 2018

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Kinetochore microtubule dynamics and attachment stability are regulated by Hec1

8 July 2018

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Self-renewal of embryonic stem cells by a small molecule

8 July 2018

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Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control

8 July 2018

1 reference

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Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C

8 July 2018

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Nek2 kinase in chromosome instability and cancer

8 July 2018

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Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage

8 July 2018

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Inhibitors of kinesin motor proteins--research and clinical progress

8 July 2018

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Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore

8 July 2018

1 reference

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Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer

8 July 2018

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Mitotic kinesins: prospects for antimitotic drug discovery.

8 July 2018

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Molecular organization of the Ndc80 complex, an essential kinetochore component

8 July 2018

1 reference

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Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth

8 July 2018

1 reference

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Hec1 and nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites

8 July 2018

1 reference

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The centrosomal kinase Nek2 displays elevated levels of protein expression in human breast cancer

8 July 2018

1 reference

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Suppression of Nek2A in mouse early embryos confirms its requirement for chromosome segregation

8 July 2018

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Timing and checkpoints in the regulation of mitotic progression

8 July 2018

1 reference

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Antitumor activity of a kinesin inhibitor

8 July 2018

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Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

8 July 2018

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Microtubules as a target for anticancer drugs

8 July 2018

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

8 July 2018

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Nuf2 and Hec1 are required for retention of the checkpoint proteins Mad1 and Mad2 to kinetochores

8 July 2018

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Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss

8 July 2018

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Assembly of functional ALT-associated promyelocytic leukemia bodies requires Nijmegen Breakage Syndrome 1

8 July 2018

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hNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells

8 July 2018

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Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation

8 July 2018

1 reference

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Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2

8 July 2018

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Gene expression profiling predicts clinical outcome of breast cancer

8 July 2018

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8 July 2018

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Cells that register logical relationships among proteins

8 July 2018

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HEC, a novel nuclear protein rich in leucine heptad repeats specifically involved in mitosis

8 July 2018

1 reference

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HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2709694

Docetaxel: a review of its pharmacology and clinical activity

8 July 2018

1 reference

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Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2709694

5-Fluoroorotic acid as a selective agent in yeast molecular genetics

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2709694

RNA interference against Hec1 inhibits tumor growth in vivo

8 July 2018

1 reference

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Live cell imaging reveals distinct roles in cell cycle regulation for Nek2A and Nek2B.

26 October 2018

1 reference

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Drosophila Nek2 protein kinase knockdown leads to centrosome maturation defects while overexpression causes centrosome fragmentation and cytokinesis failure.

26 October 2018

1 reference

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Gene expression profile of serial samples of transformed B-cell lymphomas.

26 October 2018

1 reference

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Expression analysis of pediatric solid tumor cell lines using oligonucleotide microarrays.

26 October 2018

1 reference

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Dynamic behavior of Nuf2-Hec1 complex that localizes to the centrosome and centromere and is essential for mitotic progression in vertebrate cells

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2709694

10.1158/0008-5472.CAN-08-1915

9 December 2018

Identifiers

DOI

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24 December 2019

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24 December 2019

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