Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction (Q34871118)

5 August 2017

title

Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction. (English)

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Gene Ontology release 2020-05-02

5 August 2017

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Sheng Wang

1

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5 August 2017

Junlin Yin

2

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5 August 2017

Duozhi Chen

3

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5 August 2017

Fen Nie

4

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5 August 2017

Xiaomin Song

5

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5 August 2017

Cong Fei

6

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5 August 2017

Haofei Miao

7

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5 August 2017

Changbin Jing

8

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5 August 2017

Wenjing Ma

9

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5 August 2017

Lei Wang

10

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5 August 2017

Sichun Xie

11

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5 August 2017

Chen Li

12

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5 August 2017

Rong Zeng

13

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5 August 2017

Weijun Pan

14

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5 August 2017

Xiaojiang Hao

15

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5 August 2017

Lin Li

16

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5 August 2017

publication date

28 July 2013

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5 August 2017

published in

Nature Chemical Biology

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5 August 2017

volume

9

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5 August 2017

issue

9

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5 August 2017

page(s)

579-585

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Wnt/β-catenin signaling and disease

5 August 2017

cites work

1 reference

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Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex

21 January 2018

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The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway

21 January 2018

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Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight

21 January 2018

1 reference

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Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.1309

DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathway

21 January 2018

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FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development

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naked cuticle encodes an inducible antagonist of Wnt signalling

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A molecular mechanism for the effect of lithium on development

21 January 2018

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Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

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Axin: a master scaffold for multiple signaling pathways

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AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

21 January 2018

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The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization

21 January 2018

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Zebrafish wnt8 encodes two wnt8 proteins on a bicistronic transcript and is required for mesoderm and neurectoderm patterning.

21 January 2018

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Combinatorial gene regulation by Bmp and Wnt in zebrafish posterior mesoderm formation

21 January 2018

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cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes

21 January 2018

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WNT8 and BMP2B co-regulate non-axial mesoderm patterning during zebrafish gastrulation

21 January 2018

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Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis

21 January 2018

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Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

21 January 2018

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Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway

21 January 2018

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Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-catenin

21 January 2018

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Functional domains of axin. Importance of the C terminus as an oligomerization domain

21 January 2018

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Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain

21 January 2018

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Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions

21 January 2018

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Molecular basis of Wnt activation via the DIX domain protein Ccd1

21 January 2018

1 reference

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Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling

21 January 2018

1 reference

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Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation

21 January 2018

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Wnt stabilization of β-catenin reveals principles for morphogen receptor-scaffold assemblies.

21 January 2018

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A role for Wnt signalling in self-renewal of haematopoietic stem cells

21 January 2018

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Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation

21 January 2018

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Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration

21 January 2018

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Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice

21 January 2018

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Substituted 3-imidazo[1,2-a]pyridin-3-yl- 4-(1,2,3,4-tetrahydro-[1,4]diazepino-[6,7,1-hi]indol-7-yl)pyrrole-2,5-diones as highly selective and potent inhibitors of glycogen synthase kinase-3.

21 January 2018

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Suppressive regulatory T cell activity is potentiated by glycogen synthase kinase 3{beta} inhibition

21 January 2018

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Alkaloids of the flowers of Hippeastrum vittatum.

21 January 2018

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Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells

21 January 2018

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Histone H4 Lys 20 monomethylation by histone methylase SET8 mediates Wnt target gene activation

21 January 2018

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Cloning of the zebrafish krox-20 gene (krx-20) and its expression during hindbrain development

21 January 2018

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Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation

21 January 2018

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Universal sample preparation method for proteome analysis

21 January 2018

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Super-SILAC allows classification of diffuse large B-cell lymphoma subtypes by their protein expression profiles

21 January 2018

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21 January 2018

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21 January 2018

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Determining kinetics and affinities of protein interactions using a parallel real-time label-free biosensor, the Octet

21 January 2018

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Wnt8 is required in lateral mesendodermal precursors for neural posteriorization in vivo.

21 January 2018

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12 December 2020

Activation of Wnt signaling in hematopoietic regeneration

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12 December 2020

Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts

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12 December 2020

Activation of lymphocytes by lycorine-1-O-beta-D-glucoside

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12 December 2020

Hematopoietic stem cell biology: too much of a Wnt thing

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12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.1309

1 reference

Dimensions Publication ID

5 August 2017

1032775232

0 references

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