Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-catenin (Q24630980)

identical protein binding

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Axin Dmel_CG7926

1 reference

GOA release 2020-03-11

author name string

Marc Fiedler

1

0 references

Carolina Mendoza-Topaz

2

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Trevor J Rutherford

3

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Juliusz Mieszczanek

4

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Mariann Bienz

Proceedings of the National Academy of Sciences of the United States of America

5

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language of work or name

English

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publication date

1 February 2011

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published in

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volume

108

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issue

5

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page(s)

1937-42

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cites work

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Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin

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A role of Dishevelled in relocating Axin to the plasma membrane during wingless signaling.

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Unexpectedly robust assembly of the Axin destruction complex regulates Wnt/Wg signaling in Drosophila as revealed by analysis in vivo

21 January 2018

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The Wnt signalling effector Dishevelled forms dynamic protein assemblies rather than stable associations with cytoplasmic vesicles.

21 January 2018

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Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and beta-catenin.

21 January 2018

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21 January 2018

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The DIX domain targets dishevelled to actin stress fibres and vesicular membranes

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Coexpression and protein-protein complexing of DIX domains of human Dvl1 and Axin1 protein.

21 January 2018

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28 November 2018

Identifiers

DOI

10.1073/PNAS.1017063108

1 reference

ADS bibcode

2011PNAS..108.1937F

0 references

1 reference

1 reference

PubMed publication ID

21245303

1 reference