Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression. (Q34912116)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23928995%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

title

Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression (English)

1 reference

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7 March 2020

1 reference

1 reference

10

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11

Carol A Lange

1 reference

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7 March 2020

Tarah M. Regan Anderson

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object named as

Tarah M Regan Anderson

1 reference

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author name string

Danielle L Peacock

2

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7 March 2020

Andrea R Daniel

3

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7 March 2020

Gregory K Hubbard

4

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7 March 2020

Kristopher A Lofgren

5

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7 March 2020

Brian J Girard

6

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7 March 2020

Alexandra Schörg

7

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7 March 2020

David Hoogewijs

8

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7 March 2020

Roland H Wenger

9

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7 March 2020

language of work or name

English

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publication date

8 August 2013

1 reference

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7 March 2020

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7 March 2020

volume

73

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issue

18

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7 March 2020

page(s)

5810-5820

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describes a project that uses

7 March 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3820501/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Effects of simultaneous knockdown of HER2 and PTK6 on malignancy and tumor progression in human breast cancer cells

1 reference

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Brk/PTK6 cooperates with HER2 and Src in regulating breast cancer cell survival and epithelial-to-mesenchymal transition

8 July 2018

1 reference

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Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells

8 July 2018

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Phosphorylated and sumoylation-deficient progesterone receptors drive proliferative gene signatures during breast cancer progression

8 July 2018

1 reference

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Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR

8 July 2018

1 reference

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Hypoxia-inducible factor 1α promotes primary tumor growth and tumor-initiating cell activity in breast cancer

8 July 2018

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Mechanisms of HGF/Met signaling to Brk and Sam68 in breast cancer progression

8 July 2018

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Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes

8 July 2018

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Non-canonical HIF-2α function drives autonomous breast cancer cell growth via an AREG-EGFR/ErbB4 autocrine loop.

8 July 2018

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Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPK.

8 July 2018

1 reference

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Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

8 July 2018

1 reference

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HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820501

Physical and functional interactions between Runx2 and HIF-1α induce vascular endothelial growth factor gene expression

8 July 2018

1 reference

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Analysis of tumor environmental response and oncogenic pathway activation identifies distinct basal and luminal features in HER2-related breast tumor subtypes

8 July 2018

1 reference

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ck2-dependent phosphorylation of progesterone receptors (PR) on Ser81 regulates PR-B isoform-specific target gene expression in breast cancer cells

8 July 2018

1 reference

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High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq.

8 July 2018

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Hallmarks of Cancer: The Next Generation

8 July 2018

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Brk/PTK6 signaling in normal and cancer cell models

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820501

Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells

8 July 2018

1 reference

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PTK6 regulates IGF-1-induced anchorage-independent survival

8 July 2018

1 reference

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8 July 2018

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Regulated oxygen sensing by protein hydroxylation in renal erythropoietin-producing cells

8 July 2018

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Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

8 July 2018

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Preferential binding of HIF-1 to transcriptionally active loci determines cell-type specific response to hypoxia

8 July 2018

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Met induces diverse mammary carcinomas in mice and is associated with human basal breast cancer.

8 July 2018

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Brk is coamplified with ErbB2 to promote proliferation in breast cancer

8 July 2018

1 reference

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Breast tumor kinase (protein tyrosine kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cells

8 July 2018

1 reference

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Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer

8 July 2018

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Global gene expression analysis of ERK5 and ERK1/2 signaling reveals a role for HIF-1 in ERK5-mediated responses.

8 July 2018

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Hypoxia signalling in cancer and approaches to enforce tumour regression

8 July 2018

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Integration of oxygen signaling at the consensus HRE.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820501

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820501

Simultaneous over-expression of the Her2/neu and PTK6 tyrosine kinases in archival invasive ductal breast carcinomas

8 July 2018

1 reference

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Modeling metastasis in vivo

8 July 2018

1 reference

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Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820501

Brk, Srm, Frk, and Src42A Form a Distinct Family of Intracellular Src-Like Tyrosine Kinases

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820501

Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820501

Gene expression profiling predicts clinical outcome of breast cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820501

BRK/Sik expression in the gastrointestinal tract and in colon tumors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820501

Brk, a breast tumor-derived non-receptor protein-tyrosine kinase, sensitizes mammary epithelial cells to epidermal growth factor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820501

Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820501

A novel intracellular epithelial cell tyrosine kinase is expressed in the skin and gastrointestinal tract

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820501

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820501

PTK6 promotes degradation of c-Cbl through PTK6-mediated phosphorylation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820501

Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820501

Overexpression of hypoxia-inducible factor HIF-1alpha predicts early relapse in breast cancer: retrospective study in a series of 745 patients

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23928995

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Hypoxia-inducible factor 1alpha is closely linked to an aggressive phenotype in breast cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23928995

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/0008-5472.CAN-13-0523

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23928995%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23928995%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

1 reference