Role of SMAD and non-SMAD signals in the development of Th17 and regulatory T cells (Q34927437)

5 August 2017

title

Role of SMAD and non-SMAD signals in the development of Th17 and regulatory T cells (English)

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5 August 2017

2

Julie Wang

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5 August 2017

Ling Lu

1

1 reference

5 August 2017

Feng Zhang

3

1 reference

5 August 2017

Yang Chai

4

1 reference

5 August 2017

David Brand

5

1 reference

5 August 2017

Xuehao Wang

6

1 reference

5 August 2017

David A Horwitz

7

1 reference

5 August 2017

Wei Shi

8

1 reference

5 August 2017

Song Guo Zheng

9

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5 August 2017

language of work or name

English

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publication date

19 March 2010

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5 August 2017

published in

Journal of Immunology

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5 August 2017

volume

184

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5 August 2017

issue

8

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5 August 2017

page(s)

4295-4306

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Synergistic effect of TGF-beta superfamily members on the induction of Foxp3+ Treg

5 August 2017

cites work

1 reference

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8 July 2018

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Non-Smad pathways in TGF-beta signaling

8 July 2018

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8 July 2018

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Retinoic acid increases Foxp3+ regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression

8 July 2018

1 reference

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Natural and TGF-beta-induced Foxp3(+)CD4(+) CD25(+) regulatory T cells are not mirror images of each other

8 July 2018

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8 July 2018

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Molecular antagonism and plasticity of regulatory and inflammatory T cell programs

8 July 2018

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8 July 2018

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Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer

8 July 2018

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8 July 2018

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IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner

8 July 2018

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IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells

8 July 2018

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Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid

8 July 2018

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TGFbeta signalling in control of T-cell-mediated self-reactivity

8 July 2018

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TGF-beta 1 inhibition of IFN-gamma-induced signaling and Th1 gene expression in CD4+ T cells is Smad3 independent but MAP kinase dependent

8 July 2018

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Cutting Edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells

8 July 2018

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Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-beta signaling.

8 July 2018

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Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

8 July 2018

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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

8 July 2018

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Transforming growth factor-beta induces development of the T(H)17 lineage

8 July 2018

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TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

8 July 2018

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Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7

8 July 2018

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Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

8 July 2018

1 reference

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

8 July 2018

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CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness

8 July 2018

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Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

8 July 2018

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The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Cutting edge: Foxp3+CD4+CD25+ regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6.

8 July 2018

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Deacetylase inhibition promotes the generation and function of regulatory T cells.

26 October 2018

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Active induction of experimental allergic encephalomyelitis

26 October 2018

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The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087811

IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087811

ERK1-/- mice exhibit Th1 cell polarization and increased susceptibility to experimental autoimmune encephalomyelitis.

26 October 2018

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Dihydropyrrolopyrazole transforming growth factor-beta type I receptor kinase domain inhibitors: a novel benzimidazole series with selectivity versus transforming growth factor-beta type II receptor kinase and mixed lineage kinase-7.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087811

Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087811

Smad3 is essential for TGF-beta 1 to suppress IL-2 production and TCR-induced proliferation, but not IL-2-induced proliferation

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087811

CD4+ and CD8+ regulatory T cells generated ex vivo with IL-2 and TGF-beta suppress a stimulatory graft-versus-host disease with a lupus-like syndrome

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087811

TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087811

Generation ex vivo of TGF-beta-producing regulatory T cells from CD4+CD25- precursors.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3087811

Transgenic mice with hematopoietic and lymphoid specific expression of Cre

26 October 2018

1 reference

12 December 2020

Prevention of the onset and progression of collagen-induced arthritis in rats by the potent p38 mitogen-activated protein kinase inhibitor FR167653

1 reference

12 December 2020

IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis

1 reference

12 December 2020

Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression

1 reference

12 December 2020

Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta

1 reference

12 December 2020

Cutting Edge: Trans-Signaling via the Soluble IL-6R Abrogates the Induction of FoxP3 in Naive CD4+CD25- T Cells

1 reference

12 December 2020

Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-gamma on STAT3 and Smads

1 reference

12 December 2020

The role of NF-kappaB and Smad3 in TGF-beta-mediated Foxp3 expression

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12 December 2020

Identifiers

DOI

10.4049/JIMMUNOL.0903418

1 reference

5 August 2017

1 reference

5 August 2017

1 reference