TGFbeta signalling in control of T-cell-mediated self-reactivity (Q36831664)

16 August 2017

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title

TGFbeta signalling in control of T-cell-mediated self-reactivity (English)

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16 August 2017

Yuri P Rubtsov

1

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PubMed ID

17525753

16 August 2017

Alexander Y Rudensky

series ordinal

2

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16 August 2017

1 June 2007

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Nature Reviews Immunology

16 August 2017

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16 August 2017

7

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16 August 2017

443-453

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16 August 2017

6

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Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7

16 August 2017

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Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex

21 January 2018

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NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-beta1 gene transcription

21 January 2018

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Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism

21 January 2018

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p21Cip1 and p27Kip1 act in synergy to alter the sensitivity of naive T cells to TGF-beta-mediated G1 arrest through modulation of IL-2 responsiveness.

21 January 2018

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Uncoupling of promitogenic and antiapoptotic functions of IL-2 by Smad-dependent TGF-beta signaling

21 January 2018

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A role for TGF-beta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood

21 January 2018

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Cutting Edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells

21 January 2018

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IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells

21 January 2018

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Mechanisms of TGF-beta signaling from cell membrane to the nucleus

21 January 2018

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Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer

31 March 2020

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Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth

31 March 2020

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Transforming growth factor-beta regulation of immune responses

31 March 2020

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TGFbeta1, a "Jack of all trades": the link with pro-inflammatory IL-17-producing T cells

31 March 2020

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Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms

31 March 2020

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Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor

31 March 2020

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TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

31 March 2020

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Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

31 March 2020

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Molecular aspects of regulatory T cell development

31 March 2020

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Genealogy, expression, and cellular function of transforming growth factor-β

31 March 2020

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Regulation of immune responses by TGF-beta

31 March 2020

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Targeting the stromal microenvironment in chronic inflammation.

31 March 2020

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Making sense of latent TGFbeta activation

31 March 2020

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Thrombospondin-1 is a major activator of TGF-beta1 in vivo

31 March 2020

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The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis

31 March 2020

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Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1.

31 March 2020

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Fibrillin-1 regulates the bioavailability of TGFbeta1.

31 March 2020

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Recovery from experimental allergic encephalomyelitis is TGF-beta dependent and associated with increases in CD4+LAP+ and CD4+CD25+ T cells.

31 March 2020

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Cutting Edge: Immature human dendritic cells express latency-associated peptide and inhibit T cell activation in a TGF-beta-dependent manner

31 March 2020

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The crystal structure of TGF-beta 3 and comparison to TGF-beta 2: implications for receptor binding

31 March 2020

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TGF-beta signal transduction

31 March 2020

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How cells read TGF-beta signals

31 March 2020

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SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

31 March 2020

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Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity

31 March 2020

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The nuclear import function of Smad2 is masked by SARA and unmasked by TGFbeta-dependent phosphorylation.

31 March 2020

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Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus

31 March 2020

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Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane

31 March 2020

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Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7

31 March 2020

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Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

31 March 2020

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TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses

31 March 2020

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Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses

31 March 2020

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Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

31 March 2020

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Phenotypic and functional stages in the intrathymic development of alpha beta T cells

31 March 2020

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Early progression of thymocytes along the CD4/CD8 developmental pathway is regulated by a subset of thymic epithelial cells expressing transforming growth factor beta

31 March 2020

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31 March 2020

The biology of NKT cells

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Characterization of the early stages of thymic NKT cell development

31 March 2020

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Transforming growth factor beta1 inhibits Fas ligand expression and subsequent activation-induced cell death in T cells via downregulation of c-Myc

31 March 2020

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Distinct effects of TGF-beta 1 on CD4+ and CD8+ T cell survival, division, and IL-2 production: a role for T cell intrinsic Smad3

31 March 2020

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T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells

31 March 2020

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Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease

31 March 2020

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Disruption of T cell homeostasis in mice expressing a T cell-specific dominant negative transforming growth factor beta II receptor

31 March 2020

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Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation

31 March 2020

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A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3.

31 March 2020

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Regulatory T cell lineage specification by the forkhead transcription factor foxp3

31 March 2020

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An essential role for Scurfin in CD4+CD25+ T regulatory cells

31 March 2020

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

31 March 2020

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Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

31 March 2020

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T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation

31 March 2020

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TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance

31 March 2020

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Interleukin-10-secreting type 1 regulatory T cells in rodents and humans.

31 March 2020

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31 March 2020

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T(H)-17 cells in the circle of immunity and autoimmunity

31 March 2020

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IL-17 family cytokines and the expanding diversity of effector T cell lineages

31 March 2020

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TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

31 March 2020

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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

31 March 2020

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Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

31 March 2020

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The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

31 March 2020

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Foxp3-dependent programme of regulatory T-cell differentiation

31 March 2020

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Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3.

31 March 2020

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The TGF beta receptor activation process: an inhibitor- to substrate-binding switch

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI2095

1 reference

16 August 2017

1 reference

PubMed ID

17525753