LAT, the linker for activation of T cells: a bridge between T cell-specific and general signaling pathways (Q28213042)

Science's STKE : signal transduction knowledge environment

Europe PubMed Central

title

LAT, the linker for activation of T cells: a bridge between T cell-specific and general signaling pathways (English)

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author name string

R L Wange

series ordinal

1

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language of work or name

English

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publication date

19 December 2000

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published in

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volume

2000

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issue

63

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page(s)

re1

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cites work

Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.632000RE1

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.632000RE1

Itk/Emt/Tsk activation in response to CD3 cross-linking in Jurkat T cells requires ZAP-70 and Lat and is independent of membrane recruitment

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.632000RE1

Protein modules and signalling networks

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.632000RE1

Signaling through scaffold, anchoring, and adaptor proteins

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.632000RE1

Regulation of phosphoinositide-specific phospholipase C isozymes

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.632000RE1

RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.632000RE1

Association of the tyrosine kinase LCK with phospholipase C-gamma 1 after stimulation of the T cell antigen receptor

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.632000RE1

Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.632000RE1

Signalling through the lipid products of phosphoinositide-3-OH kinase

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.632000RE1

Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T-cell signalling

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.632000RE1

Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.632000RE1

T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.632000RE1

Cloning and characterization of Lnk, a signal transduction protein that links T-cell receptor activation signal to phospholipase C gamma 1, Grb2, and phosphatidylinositol 3-kinase

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.632000RE1

Characterization of Lnk. An adaptor protein expressed in lymphocytes

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.632000RE1

Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.632000RE1

SH2 domains recognize specific phosphopeptide sequences

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.632000RE1

The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.632000RE1

Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.632000RE1

Mona, a novel hematopoietic-specific adaptor interacting with the macrophage colony-stimulating factor receptor, is implicated in monocyte/macrophage development

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.632000RE1

Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.632000RE1

The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.632000RE1

Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.632000RE1

Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.632000RE1

Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.632000RE1

Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.632000RE1

Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.632000RE1

Regulatory intramolecular association in a tyrosine kinase of the Tec family

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.632000RE1

Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.632000RE1

Interaction of SLP adaptors with the SH2 domain of Tec family kinases

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.632000RE1

Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.632000RE1

Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.632000RE1

Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCISIGNAL.632000RE1

Signaling--2000 and beyond

21 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

Functions of lipid rafts in biological membranes

21 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

The role of SLP-76 and LAT in lymphocyte development

21 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

Regulation of antigen receptor function by protein tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

Recent developments in lymphocyte activation: linking kinases to downstream signaling events

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

Binding of ZAP-70 to phosphorylated T-cell receptor zeta and eta enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

Regulation of antigen receptor signal transduction by protein tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

Signal transduction events leading to T-cell lymphokine gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

Tyrosine phosphorylation in T cells is regulated by phosphatase activity: studies with phenylarsine oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

Regulation of RasGRP via a phorbol ester-responsive C1 domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

Eyes wide shut: protein kinase C isozymes are not the only receptors for the phorbol ester tumor promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

Sulfhydryl oxidation down-regulates T-cell signaling and inhibits tyrosine phosphorylation of phospholipase C gamma 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

SH2/SH3 signaling proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

Signaling networks--do all roads lead to the same genes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

Phorbol ester treatment inhibits phosphatidylinositol 3-kinase activation by, and association with, CD28, a T-lymphocyte surface receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

Phosphatidylinositol 3-kinase activity is not essential for CD28 costimulatory activity in Jurkat T cells: studies with a selective inhibitor, wortmannin

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

T cell activation-dependent association between the p85 subunit of the phosphatidylinositol 3-kinase and Grb2/phospholipase C-gamma 1-binding phosphotyrosyl protein pp36/38.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

Localization of LAT in glycolipid-enriched microdomains is required for T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

TCR/CD3-Induced activation and binding of Emt/Itk to linker of activated T cell complexes: requirement for the Src homology 2 domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

Isolation and characterization of a T-lymphocyte somatic mutant with altered signal transduction by the antigen receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

The phosphotyrosine phosphatase SHP-2 participates in a multimeric signaling complex and regulates T cell receptor (TCR) coupling to the Ras/mitogen-activated protein kinase (MAPK) pathway in Jurkat T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

Tyrosine phosphorylation of Grb2-associated proteins correlates with phospholipase C gamma 1 activation in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

Membrane compartmentation and the response to antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

The role of lipid rafts in T cell antigen receptor (TCR) signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

GPI-anchored proteins are organized in submicron domains at the cell surface.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

Microdomains of GPI-anchored proteins in living cells revealed by crosslinking

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

Localization and turnover of phosphatidylinositol 4,5-bisphosphate in caveolin-enriched membrane domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

Intracellular adapter molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

T cell receptor signalling results in rapid tyrosine phosphorylation of the linker protein LAT present in detergent-resistant membrane microdomains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-gamma1 and Ras activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

ZAP-70-dependent and -independent activation of Erk in Jurkat T cells. Differences in signaling induced by H2o2 and Cd3 cross-linking

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

Redox regulation of signal transduction: tyrosine phosphorylation and calcium influx

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

Regulation of the OxyR transcription factor by hydrogen peroxide and the cellular thiol-disulfide status

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

Bridge over troubled waters: sensing stress by disulfide bond formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

Reversible inactivation of protein-tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

CD4 and CD8 T cells with high intracellular glutathione levels are selectively lost as the HIV infection progresses

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1

Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.632000RE1