CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement (Q34985437)

5 August 2017

CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement (English)

1 reference

5 August 2017

1 reference

9

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12 June 2020

Lucy Walker

10

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12 June 2020

author name string

Chun Jing Wang

1

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12 June 2020

Frank Heuts

2

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12 June 2020

Vitalijs Ovcinnikovs

3

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12 June 2020

Lukasz Wardzinski

4

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12 June 2020

Chantelle Bowers

5

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12 June 2020

Emily M Schmidt

6

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12 June 2020

Alexandros Kogimtzis

7

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12 June 2020

Rupert Kenefeck

8

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12 June 2020

language of work or name

English

0 references

publication date

29 December 2014

1 reference

Proceedings of the National Academy of Sciences of the United States of America

5 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25548162%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

volume

112

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12 June 2020

page(s)

524-529

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12 June 2020

issue

2

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IL-21 promotes CD4 T cell responses by phosphatidylinositol 3-kinase-dependent upregulation of CD86 on B cells

12 June 2020

cites work

1 reference

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Human T follicular helper (Tfh) cells and disease

8 July 2018

1 reference

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microRNA-17-92 regulates IL-10 production by regulatory T cells and control of experimental autoimmune encephalomyelitis.

8 July 2018

1 reference

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Treg and CTLA-4: two intertwining pathways to immune tolerance

8 July 2018

1 reference

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The microRNA cluster miR-17∼92 promotes TFH cell differentiation and represses subset-inappropriate gene expression.

8 July 2018

1 reference

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MicroRNAs of the miR-17∼92 family are critical regulators of T(FH) differentiation

8 July 2018

1 reference

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Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression

8 July 2018

1 reference

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The good, the bad and the ugly - TFH cells in human health and disease

8 July 2018

1 reference

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Convergent and divergent effects of costimulatory molecules in conventional and regulatory CD4+ T cells

8 July 2018

1 reference

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Cutting edge: cell-extrinsic immune regulation by CTLA-4 expressed on conventional T cells

8 July 2018

1 reference

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Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation

8 July 2018

1 reference

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CD80 expression on B cells regulates murine T follicular helper development, germinal center B cell survival, and plasma cell generation

8 July 2018

1 reference

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STAT5 is a potent negative regulator of TFH cell differentiation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

Regulation of the germinal center reaction by Foxp3+ follicular regulatory T cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

Foxp3+ follicular regulatory T cells control the germinal center response.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

B cell-specific expression of B7-2 is required for follicular Th cell function in response to vaccinia virus

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

Inhibition of follicular T-helper cells by CD8(+) regulatory T cells is essential for self tolerance.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase.

8 July 2018

1 reference

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Follicular helper T cells are required for systemic autoimmunity

8 July 2018

1 reference

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Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

CTLA-4 control over Foxp3+ regulatory T cell function

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis

8 July 2018

1 reference

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Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

Induction of autoimmune disease in CTLA-4-/- mice depends on a specific CD28 motif that is required for in vivo costimulation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genes

8 July 2018

1 reference

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Cytotoxic T lymphocyte antigen-4-dependent down-modulation of costimulatory molecules on dendritic cells in CD4+ CD25+ regulatory T-cell-mediated suppression

8 July 2018

1 reference

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A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

8 July 2018

1 reference

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The B7/CD28 costimulatory family in autoimmunity

8 July 2018

1 reference

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CTLA4 gene polymorphism and autoimmunity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

Established T cell-driven germinal center B cell proliferation is independent of CD28 signaling but is tightly regulated through CTLA-4.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

ICOS is essential for effective T-helper-cell responses

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

ICOS is critical for CD40-mediated antibody class switching

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

ICOS co-stimulatory receptor is essential for T-cell activation and function

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5-positive CD4 cells and germinal centers.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

Dendritic cell-restricted CD80/86 deficiency results in peripheral regulatory T-cell reduction but is not associated with lymphocyte hyperactivation.

8 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1414576112

Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1414576112

Altered expression of chemokine receptor CXCR5 on T cells of myasthenia gravis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1414576112

Cutting Edge: CTLA-4 on Effector T Cells Inhibits In Trans

21 January 2018

2 references

https://api.crossref.org/works/10.1073%2FPNAS.1414576112

21 January 2018

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

A differential requirement for phosphoinositide 3-kinase reveals two pathways for inducible upregulation of major histocompatibility complex class II molecules and CD86 expression by murine B lymphocytes

26 October 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1414576112

Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1414576112

Functional hierarchy and relative contribution of the CD28/B7 and ICOS/B7-H2 costimulatory pathways to T cell-mediated delayed-type hypersensitivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1414576112

High frequencies of activated B cells and T follicular helper cells are correlated with disease activity in patients with new-onset rheumatoid arthritis.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

Ctla-4 controls regulatory T cell peripheral homeostasis and is required for suppression of pancreatic islet autoimmunity

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

Cutting edge: critical role of inducible costimulator in germinal center reactions

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

CD28 is required for germinal center formation.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4299196

CD28 activation promotes Th2 subset differentiation by human CD4+ cells

26 October 2018

1 reference

12 December 2020

CD28 costimulation promotes the production of Th2 cytokines

1 reference

12 December 2020

Role of costimulators in T cell differentiation: studies using antigen-presenting cells lacking expression of CD80 or CD86

1 reference

12 December 2020

Clonal expansions of CD4+ B helper T cells in autoimmune myasthenia gravis

1 reference

12 December 2020

Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1414576112

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25548162%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25548162%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25548162%20AND%20SRC:MED&resulttype=core&format=json