The good, the bad and the ugly - TFH cells in human health and disease (Q38107389)

29 August 2017

The good, the bad and the ugly - TFH cells in human health and disease (English)

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29 August 2017

T follicular helper cell

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2

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29 August 2017

4

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29 August 2017

Stuart G Tangye

1

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PubMed ID

23681096

29 August 2017

Robert Brink

series ordinal

3

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29 August 2017

17 May 2013

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Nature Reviews Immunology

29 August 2017

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29 August 2017

13

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29 August 2017

412-426

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29 August 2017

6

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https://scigraph.springernature.com/pub.10.1038/nri3447

29 August 2017

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cites work

Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells

1 reference

Primary immunodeficiency diseases: an update on the classification from the international union of immunological societies expert committee for primary immunodeficiency

21 January 2018

1 reference

Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production

21 January 2018

1 reference

CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function

21 January 2018

1 reference

Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells

21 January 2018

1 reference

Human CD57+ germinal center-T cells are the major helpers for GC-B cells and induce class switch recombination

21 January 2018

1 reference

T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells

21 January 2018

1 reference

A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

21 January 2018

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Control systems and decision making for antibody production.

21 January 2018

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21 January 2018

1 reference

Affinity-based selection and the germinal center response

21 January 2018

1 reference

Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation.

21 January 2018

1 reference

Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation

21 January 2018

1 reference

Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12.

21 January 2018

1 reference

Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling.

21 January 2018

1 reference

Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150)

21 January 2018

1 reference

Human tonsil B-cell lymphoma 6 (BCL6)-expressing CD4+ T-cell subset specialized for B-cell help outside germinal centers

21 January 2018

1 reference

Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation

21 January 2018

1 reference

Bcl6 mediates the development of T follicular helper cells

21 January 2018

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The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment.

21 January 2018

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Follicular helper CD4 T cells (TFH)

21 January 2018

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The origins, function, and regulation of T follicular helper cells

21 January 2018

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Germinal center B and follicular helper T cells: siblings, cousins or just good friends?

21 January 2018

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Follicular helper T cells in immunity and systemic autoimmunity

21 January 2018

1 reference

Noncanonical NF-kappaB regulates inducible costimulator (ICOS) ligand expression and T follicular helper cell development

21 January 2018

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Deficiency in TNFRSF13B (TACI) expands T-follicular helper and germinal center B cells via increased ICOS-ligand expression but impairs plasma cell survival

21 January 2018

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ICOS deficiency is associated with a severe reduction of CXCR5+CD4 germinal center Th cells.

21 January 2018

1 reference

Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages

21 January 2018

1 reference

Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules.

21 January 2018

1 reference

SAP-controlled T-B cell interactions underlie germinal centre formation

21 January 2018

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Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84.

21 January 2018

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Follicular helper T cells are required for systemic autoimmunity

21 January 2018

1 reference

The receptor Ly108 functions as a SAP adaptor-dependent on-off switch for T cell help to B cells and NKT cell development

21 January 2018

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PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells

21 January 2018

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B7-H1 expression on non-B and non-T cells promotes distinct effects on T- and B-cell responses in autoimmune arthritis.

21 January 2018

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Blockade of B7-H1 (programmed death ligand 1) enhances humoral immunity by positively regulating the generation of T follicular helper cells.

21 January 2018

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Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection

21 January 2018

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Inadequate T follicular cell help impairs B cell immunity during HIV infection.

21 January 2018

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The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood.

21 January 2018

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IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation

21 January 2018

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Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection

21 January 2018

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B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1

21 January 2018

1 reference

Cutting edge: STAT1 is required for IL-6-mediated Bcl6 induction for early follicular helper cell differentiation

21 January 2018

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Functional STAT3 deficiency compromises the generation of human T follicular helper cells.

21 January 2018

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Tolerogenic function of Blimp-1 in dendritic cells

21 January 2018

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STAT5 is a potent negative regulator of TFH cell differentiation

21 January 2018

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Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells.

21 January 2018

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Distinct memory CD4+ T cells with commitment to T follicular helper- and T helper 1-cell lineages are generated after acute viral infection.

21 January 2018

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Bcl6 expressing follicular helper CD4 T cells are fate committed early and have the capacity to form memory

21 January 2018

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Bcl6 expression specifies the T follicular helper cell program in vivo

21 January 2018

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The development and fate of follicular helper T cells defined by an IL-21 reporter mouse.

21 January 2018

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T-follicular helper cells survive as long-term memory cells.

21 January 2018

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Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion

21 January 2018

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Induction of ICOS+CXCR3+CXCR5+ TH cells correlates with antibody responses to influenza vaccination

21 January 2018

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Invariant NKT cells sustain specific B cell responses and memory

21 January 2018

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B cell receptor-mediated uptake of CD1d-restricted antigen augments antibody responses by recruiting invariant NKT cell help in vivo

21 January 2018

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NK T cells provide lipid antigen-specific cognate help for B cells

21 January 2018

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NKT-cell help to B lymphocytes can occur independently of cognate interaction.

21 January 2018

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Follicular helper NKT cells induce limited B cell responses and germinal center formation in the absence of CD4(+) T cell help

21 January 2018

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Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner

21 January 2018

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Six-of-the-best: unique contributions of γδ T cells to immunology

21 January 2018

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CXCR5 identifies a subset of Vgamma9Vdelta2 T cells which secrete IL-4 and IL-10 and help B cells for antibody production.

21 January 2018

1 reference

Retracted: IL-21 Regulates the Differentiation of a Human γδ T Cell Subset Equipped with B Cell Helper Activity

21 January 2018

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Distinct cytokine-driven responses of activated blood gammadelta T cells: insights into unconventional T cell pleiotropy

21 January 2018

1 reference

Elimination of germinal-center-derived self-reactive B cells is governed by the location and concentration of self-antigen.

21 January 2018

1 reference

Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses

21 January 2018

1 reference

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions

21 January 2018

1 reference

Foxp3+ follicular regulatory T cells control the germinal center response.

21 January 2018

1 reference

Regulation of the germinal center reaction by Foxp3+ follicular regulatory T cells

21 January 2018

1 reference

Regulatory T cells: mechanisms of differentiation and function

21 January 2018

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Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4+ CD25- LAP+ regulatory T cell and is associated with down-regulation of IL-17+ CD4+ ICOS+ CXCR5+ follicular helper T cells

21 January 2018

1 reference

CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses.

21 January 2018

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Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity.

21 January 2018

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Upregulation of IL-21 receptor on B cells and IL-21 secretion distinguishes novel 2009 H1N1 vaccine responders from nonresponders among HIV-infected persons on combination antiretroviral therapy

21 January 2018

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Impaired peripheral blood T-follicular helper cell function in HIV-infected nonresponders to the 2009 H1N1/09 vaccine

21 January 2018

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Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells.

21 January 2018

1 reference

Altered expression of chemokine receptor CXCR5 on T cells of myasthenia gravis patients

21 January 2018

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Inhibition of aberrant circulating Tfh cell proportions by corticosteroids in patients with systemic lupus erythematosus

21 January 2018

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Interleukin 21 correlates with T cell and B cell subset alterations in systemic lupus erythematosus.

21 January 2018

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A regulatory effect of IL-21 on T follicular helper-like cell and B cell in rheumatoid arthritis

21 January 2018

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Role of the frequency of blood CD4(+) CXCR5(+) CCR6(+) T cells in autoimmunity in patients with Sjögren's syndrome.

21 January 2018

1 reference

The phenotype of circulating follicular-helper T cells in patients with rheumatoid arthritis defines CD200 as a potential therapeutic target

21 January 2018

1 reference

Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4+ T cells

21 January 2018

1 reference

IL-12 receptor β1 deficiency alters in vivo T follicular helper cell response in humans

21 January 2018

1 reference

B cells in HIV infection and disease

21 January 2018

1 reference

Expansion of HIV-specific T follicular helper cells in chronic HIV infection

21 January 2018

1 reference

CD4 T follicular helper cell dynamics during SIV infection

21 January 2018

1 reference

Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production

21 January 2018

1 reference

Simian immunodeficiency virus infects follicular helper CD4 T cells in lymphoid tissues during pathogenic infection of pigtail macaques

21 January 2018

1 reference

Advances in the understanding and management of angioimmunoblastic T-cell lymphoma

21 January 2018

1 reference

Follicular T-cell lymphoma: a member of an emerging family of follicular helper T-cell derived T-cell lymphomas

21 January 2018

1 reference

The inducible T-cell co-stimulator molecule is expressed on subsets of T cells and is a new marker of lymphomas of T follicular helper cell-derivation

21 January 2018

1 reference

The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells

21 January 2018

1 reference

Molecular signatures to improve diagnosis in peripheral T-cell lymphoma and prognostication in angioimmunoblastic T-cell lymphoma

21 January 2018

1 reference

Peripheral T-cell lymphoma with follicular T-cell markers

21 January 2018

1 reference

TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis

21 January 2018

1 reference

IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma

21 January 2018

1 reference

Recurrent TET2 mutations in peripheral T-cell lymphomas correlate with TFH-like features and adverse clinical parameters

21 January 2018

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Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

21 January 2018

1 reference

IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells.

21 January 2018

1 reference

B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

21 January 2018

1 reference

Cutting edge: IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells

21 January 2018

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IL-21-induced isotype switching to IgG and IgA by human naive B cells is differentially regulated by IL-4.

21 January 2018

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A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage

21 January 2018

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Type 17 T helper cells-origins, features and possible roles in rheumatic disease

21 January 2018

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Allergic asthma: a tale of many T cells.

21 January 2018

1 reference

21 January 2018

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The symphony of the ninth: the development and function of Th9 cells

21 January 2018

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Interleukin-22: a cytokine produced by T, NK and NKT cell subsets, with importance in the innate immune defense and tissue protection

21 January 2018

1 reference

Expression of two markers of germinal center T cells (SAP and PD-1) in angioimmunoblastic T-cell lymphoma

21 January 2018

1 reference

Heterozygosity for Roquinsan leads to angioimmunoblastic T-cell lymphoma-like tumors in mice

21 January 2018

1 reference

Thymus and the Production of Antibody-plaque-forming Cells

21 January 2018

1 reference

Follicular B helper T cell activity is confined to CXCR5(hi)ICOS(hi) CD4 T cells and is independent of CD57 expression

21 January 2018

1 reference

A regulatory role for IL-10 receptor signaling in development and B cell help of T follicular helper cells in mice

31 March 2020

1 reference

Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses

31 March 2020

1 reference

Flexible migration program regulates gamma delta T-cell involvement in humoral immunity

31 March 2020

1 reference

Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus

31 March 2020

1 reference

Expression of the B cell-attracting chemokine CXCL13 in the target organ and autoantibody production in ectopic lymphoid tissue in the chronic inflammatory disease Sjögren's syndrome

31 March 2020

1 reference

Involvement of inducible costimulator in the exaggerated memory B cell and plasma cell generation in systemic lupus erythematosus

31 March 2020

1 reference

Clonal expansions of CD4+ B helper T cells in autoimmune myasthenia gravis

31 March 2020

1 reference

Increased frequency of follicular helper T cells in patients with autoimmune thyroid disease

31 March 2020

1 reference

Elevated production of B cell chemokine CXCL13 is correlated with systemic lupus erythematosus disease activity

31 March 2020

1 reference

Phenotype of neoplastic cells in angioimmunoblastic T-cell lymphoma is consistent with activated follicular B helper T cells

31 March 2020

1 reference

Clinicopathologic analysis of peripheral T-cell lymphoma, follicular variant, and comparison with angioimmunoblastic T-cell lymphoma: Bcl-6 expression might affect progression between these disorders

31 March 2020

1 reference

Human B lymphocytes: phenotype, proliferation, and differentiation

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23681096

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Increased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23681096

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRI3447

1 reference

PubMed ID

23681096

Dimensions Publication ID

29 August 2017

0 references

1 reference

PubMed ID

23681096