Fragile X mental retardation protein in plasticity and disease (Q34993137)

5 August 2017

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title

Fragile X mental retardation protein in plasticity and disease (English)

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5 August 2017

Peter K Todd

1

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PubMed ID

12424729

5 August 2017

James S Malter

series ordinal

2

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5 August 2017

1 December 2002

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Journal of Neuroscience Research

5 August 2017

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5 August 2017

70

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5 August 2017

5

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5 August 2017

623-630

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Dissecting FMR1, the protein responsible for fragile X syndrome, in its structural and functional domains

5 August 2017

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Human and murine FMR-1: alternative splicing and translational initiation downstream of the CGG-repeat.

21 January 2018

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FMR1 protein: conserved RNP family domains and selective RNA binding

21 January 2018

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A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein

21 January 2018

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Group I metabotropic glutamate receptors: implications for brain diseases

21 January 2018

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FMRP involvement in formation of synapses among cultured hippocampal neurons.

21 January 2018

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Purified recombinant Fmrp exhibits selective RNA binding as an intrinsic property of the fragile X mental retardation protein

21 January 2018

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Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome

21 January 2018

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Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex

21 January 2018

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Identification of mouse YB1/p50 as a component of the FMRP-associated mRNP particle

21 January 2018

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Fragile X mice develop sensory hyperreactivity to auditory stimuli

21 January 2018

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Specific dephosphorylation of the Lck tyrosine protein kinase at Tyr-394 by the SHP-1 protein-tyrosine phosphatase

21 January 2018

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Abnormal dendritic spines in fragile X knockout mice: maturation and pruning deficits

21 January 2018

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Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1.

21 January 2018

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The fragile X mental retardation protein is associated with poly(A)+ mRNA in actively translating polyribosomes

21 January 2018

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Trinucleotide repeats: mechanisms and pathophysiology

21 January 2018

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Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function

21 January 2018

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A point mutation in the FMR-1 gene associated with fragile X mental retardation

21 January 2018

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Screening and diagnosis for the fragile X syndrome among the mentally retarded: an epidemiological and psychological survey. Collaborative Fragile X Study Group

21 January 2018

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The FMR-1 protein is cytoplasmic, most abundant in neurons and appears normal in carriers of a fragile X premutation

21 January 2018

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Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest

21 January 2018

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Premutation and intermediate-size FMR1 alleles in 10572 males from the general population: loss of an AGG interruption is a late event in the generation of fragile X syndrome alleles

21 January 2018

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Translational suppression by trinucleotide repeat expansion at FMR1.

21 January 2018

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FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association

21 January 2018

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Synaptic regulation of protein synthesis and the fragile X protein

21 January 2018

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Intention tremor, parkinsonism, and generalized brain atrophy in male carriers of fragile X.

21 January 2018

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Tissue-specific expression of a FMR1/beta-galactosidase fusion gene in transgenic mice.

21 January 2018

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Analysis of neocortex in three males with the fragile X syndrome

21 January 2018

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Altered synaptic plasticity in a mouse model of fragile X mental retardation

21 January 2018

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Evidence for altered Fragile-X mental retardation protein expression in response to behavioral stimulation

21 January 2018

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Abnormal dendritic spine characteristics in the temporal and visual cortices of patients with fragile-X syndrome: a quantitative examination.

21 January 2018

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Understanding the molecular basis of fragile X syndrome

21 January 2018

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Induction of long-term depression in cerebellar Purkinje cells requires a rapidly turned over protein

21 January 2018

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Reduced FMRP and increased FMR1 transcription is proportionally associated with CGG repeat number in intermediate-length and premutation carriers.

21 January 2018

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Biology of the fragile X mental retardation protein, an RNA-binding protein

21 January 2018

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The fragile X mental retardation protein is associated with ribosomes

21 January 2018

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Interaction of the transcription factors USF1, USF2, and alpha -Pal/Nrf-1 with the FMR1 promoter. Implications for Fragile X mental retardation syndrome

21 January 2018

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Evidence that fragile X mental retardation protein is a negative regulator of translation

21 January 2018

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Reduced cortical synaptic plasticity and GluR1 expression associated with fragile X mental retardation protein deficiency.

21 January 2018

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The fragile X mental retardation protein inhibits translation via interacting with mRNA

21 January 2018

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Intragenic loss of function mutations demonstrate the primary role of FMR1 in fragile X syndrome

21 January 2018

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Role of group I metabotropic glutamate receptors in the patterning of epileptiform activities in vitro.

21 January 2018

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Requirement of protein synthesis for group I mGluR-mediated induction of epileptiform discharges

21 January 2018

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Drosophila fragile X protein, DFXR, regulates neuronal morphology and function in the brain

21 January 2018

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The human 20-kDa 5'-(CGG)(n)-3'-binding protein is targeted to the nucleus and affects the activity of the FMR1 promoter

21 January 2018

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Audiogenic seizures susceptibility in transgenic mice with fragile X syndrome.

21 January 2018

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Alterations in the auditory startle response in Fmr1 targeted mutant mouse models of fragile X syndrome.

21 January 2018

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Instability of a 550-base pair DNA segment and abnormal methylation in fragile X syndrome

21 January 2018

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Lipoxygenase mRNA silencing in erythroid differentiation: The 3'UTR regulatory complex controls 60S ribosomal subunit joining

21 January 2018

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Fragile X mouse: strain effects of knockout phenotype and evidence suggesting deficient amygdala function.

21 January 2018

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Dendritic Spine "Dysgenesis" and Mental Retardation

21 January 2018

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Postmortem examination of two fragile X brothers with an FMR1 full mutation.

21 January 2018

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Adult fragile X syndrome. Clinico-neuropathologic findings.

21 January 2018

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The fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motif

21 January 2018

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A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P

21 January 2018

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Characterization of FMR1 promoter elements by in vivo-footprinting analysis.

21 January 2018

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Premature ovarian failure in the fragile X syndrome

21 January 2018

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The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein

21 January 2018

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Essential role for KH domains in RNA binding: impaired RNA binding by a mutation in the KH domain of FMR1 that causes fragile X syndrome

21 January 2018

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Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them

21 January 2018

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Internalization of ionotropic glutamate receptors in response to mGluR activation

21 January 2018

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RNAs that interact with the fragile X syndrome RNA binding protein FMRP.

21 January 2018

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Oligomerization properties of fragile-X mental-retardation protein (FMRP) and the fragile-X-related proteins FXR1P and FXR2P

21 January 2018

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Elevated levels of FMR1 mRNA in carrier males: a new mechanism of involvement in the fragile-X syndrome.

21 January 2018

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A majority of fragile X males with methylated, full mutation alleles have significant levels of FMR1 messenger RNA.

21 January 2018

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Induction or protection of limbic seizures in mice by mGluR subtype selective agonists

21 January 2018

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Sensory stimulation increases cortical expression of the fragile X mental retardation protein in vivo.

21 January 2018

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Male with typical fragile X phenotype is deleted for part of the FMR1 gene and for about 100 kb of upstream region.

21 January 2018

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Fragile X (fmr1) mRNA expression is differentially regulated in two adult models of activity-dependent gene expression

21 January 2018

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Characterization and localization of the FMR-1 gene product associated with fragile X syndrome

21 January 2018

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Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome

21 January 2018

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Abnormal pattern detected in fragile-X patients by pulsed-field gel electrophoresis

21 January 2018

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Characterization of dFMR1, a Drosophila melanogaster homolog of the fragile X mental retardation protein

21 January 2018

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Metabotropic glutamate receptors trigger postsynaptic protein synthesis

21 January 2018

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Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation

21 January 2018

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The Fra(X) syndrome: neurological, electrophysiological, and neuropathological abnormalities.

21 January 2018

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Metabotropic glutamate receptor activation causes a rapid redistribution of AMPA receptors

21 January 2018

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Fragile X genotype characterized by an unstable region of DNA.

21 January 2018

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Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function

21 January 2018

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A heterogeneous set of FMR1 proteins is widely distributed in mouse tissues and is modulated in cell culture

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JNR.10453

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5 August 2017

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PubMed ID

12424729