The structures of prostaglandin endoperoxide H synthases-1 and -2. (Q34997939)

5 August 2017

1 reference

title

The structures of prostaglandin endoperoxide H synthases-1 and -2. (English)

1 reference

5 August 2017

R Michael Garavito

1

1 reference

PubMed ID

12432914

5 August 2017

Michael G Malkowski

series ordinal

2

1 reference

PubMed ID

12432914

5 August 2017

David L DeWitt

series ordinal

3

1 reference

5 August 2017

1 August 2002

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Prostaglandins and Other Lipid Mediators

5 August 2017

1 reference

5 August 2017

68-69

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5 August 2017

129-152

1 reference

Cyclooxygenases: structural, cellular, and molecular biology

5 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Arachidonic acid oxygenation by COX-1 and COX-2. Mechanisms of catalysis and inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Cyclooxygenase-1 and -2 isoenzymes

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Prostaglandin synthase 2.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Different intracellular locations for prostaglandin endoperoxide H synthase-1 and -2.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

The membrane binding domains of prostaglandin endoperoxide H synthases 1 and 2. Peptide mapping and mutational analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Aspirin as an antiplatelet drug

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Basic biology and clinical application of specific cyclooxygenase-2 inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

The role of cyclooxygenases in inflammation, cancer, and development

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Inflammation of the brain in Alzheimer's disease: implications for therapy.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

On the functional of neuromelanin.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Photolabeling of Prostaglandin Endoperoxide H Synthase-1 with 3-Trifluoro-3-(m-Iiodophenyl)diazirine as a Probe of Membrane Association and the Cyclooxygenase Active Site

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Purification and characterization of the human recombinant histidine-tagged prostaglandin endoperoxide H synthases-1 and -2.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Purification and characterisation of prostaglandin endoperoxide synthetase from sheep vesicular glands

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

The formation of stable fatty acid substrate complexes in prostaglandin H(2) synthase-1

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Structural characterization of arachidonyl radicals formed by prostaglandin H synthase-2 and prostaglandin H synthase-1 reconstituted with mangano protoporphyrin IX

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Comparison of peroxidase reaction mechanisms of prostaglandin H synthase-1 containing heme and mangano protoporphyrin IX

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

The productive conformation of arachidonic acid bound to prostaglandin synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Mutational and X-ray crystallographic analysis of the interaction of dihomo-gamma -linolenic acid with prostaglandin endoperoxide H synthases

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Structure of eicosapentaenoic and linoleic acids in the cyclooxygenase site of prostaglandin endoperoxide H synthase-1

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Structural insights into the stereochemistry of the cyclooxygenase reaction

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Comparison of structural stabilities of prostaglandin H synthase-1 and -2.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Epidermal growth factor-like modules

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Prostaglandin H synthase: implications for membrane structure.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

The membrane association sequences of the prostaglandin endoperoxide synthases-1 and -2 isozymes

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Anchoring of a monotopic membrane protein: the binding of prostaglandin H2 synthase-1 to the surface of a phospholipid bilayer.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Synthesis and use of iodinated nonsteroidal antiinflammatory drug analogs as crystallographic probes of the prostaglandin H2 synthase cyclooxygenase active site

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Peroxidase activity in prostaglandin endoperoxide H synthase-1 occurs with a neutral histidine proximal heme ligand

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Crystal structure of horseradish peroxidase C at 2.15 A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Mutational analysis of the role of the distal histidine and glutamine residues of prostaglandin-endoperoxide synthase-2 in peroxidase catalysis, hydroperoxide reduction, and cyclooxygenase activation

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Metal-ligand vibrations of cyanoferric myeloperoxidase and cyanoferric horseradish peroxidase: evidence for a constrained heme pocket in myeloperoxidase

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

X-ray crystal structure of canine myeloperoxidase at 3 A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

The cyclooxygenase isoforms: structural insights into the conversion of arachidonic acid to prostaglandins

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Involvement of arginine 120, glutamate 524, and tyrosine 355 in the binding of arachidonate and 2-phenylpropionic acid inhibitors to the cyclooxygenase active site of ovine prostaglandin endoperoxide H synthase-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

The role of arginine 120 of human prostaglandin endoperoxide H synthase-2 in the interaction with fatty acid substrates and inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Cyclooxygenase mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Control of prostaglandin stereochemistry at the 15-carbon by cyclooxygenases-1 and -2. A critical role for serine 530 and valine 349

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Prostaglandin endoperoxide H synthase-1: the functions of cyclooxygenase active site residues in the binding, positioning, and oxygenation of arachidonic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Different catalytically competent arrangements of arachidonic acid within the cyclooxygenase active site of prostaglandin endoperoxide H synthase-1 lead to the formation of different oxygenated products

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Analysis of hydroperoxide-induced tyrosyl radicals and lipoxygenase activity in aspirin-treated human prostaglandin H synthase-2

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Fatty acid substrate specificities of human prostaglandin-endoperoxide H synthase-1 and -2. Formation of 12-hydroxy-(9Z, 13E/Z, 15Z)- octadecatrienoic acids from alpha-linolenic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

The binding of arachidonic acid in the cyclooxygenase active site of mouse prostaglandin endoperoxide synthase-2 (COX-2). A putative L-shaped binding conformation utilizing the top channel region

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Arginine 120 of prostaglandin G/H synthase-1 is required for the inhibition by nonsteroidal anti-inflammatory drugs containing a carboxylic acid moiety

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

The interaction of arginine 106 of human prostaglandin G/H synthase-2 with inhibitors is not a universal component of inhibition mediated by nonsteroidal anti-inflammatory drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

The dynamics of prostaglandin H synthases. Studies with prostaglandin h synthase 2 Y355F unmask mechanisms of time-dependent inhibition and allosteric activation

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Mutation of serine-516 in human prostaglandin G/H synthase-2 to methionine or aspirin acetylation of this residue stimulates 15-R-HETE synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Stereospecificity of hydrogen abstraction in the conversion of arachidonic acid to 15R-HETE by aspirin-treated cyclooxygenase-2. Implications for the alignment of substrate in the active site

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Turning down the heat: new routes to inhibition of inflammatory signaling by prostaglandin H2 synthases

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Structural requirements for time-dependent inhibition of prostaglandin biosynthesis by anti-inflammatory drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Role of Val509 in time-dependent inhibition of human prostaglandin H synthase-2 cyclooxygenase activity by isoform-selective agents

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Conversion of prostaglandin G/H synthase-1 into an enzyme sensitive to PGHS-2-selective inhibitors by a double His513 --> Arg and Ile523 --> val mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Protection of prostaglandin H synthase from trypsin upon binding of heme

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

C-terminal Ser/Pro-Thr-Glu-Leu tetrapeptides of prostaglandin endoperoxide H synthases-1 and -2 target the enzymes to the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

SETOR: hardware-lighted three-dimensional solid model representations of macromolecules

1 reference

https://api.crossref.org/works/10.1016%2FS0090-6980%2802%2900026-6

7 January 2021

10.1016/S0090-6980(02)00026-6

Identifiers

DOI

1 reference

5 August 2017

1 reference

PubMed ID

12432914