Regulation of outside-in signaling and affinity by the beta2 I domain of integrin alphaLbeta2. (Q35016499)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16920795%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

title

Regulation of outside-in signaling and affinity by the beta2 I domain of integrin alphaLbeta2 (English)

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29 December 2019

author

Christopher V. Carman

4

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29 December 2019

author name string

JianFeng Chen

1

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29 December 2019

Wei Yang

2

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29 December 2019

Minsoo Kim

3

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29 December 2019

Timothy A Springer

5

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29 December 2019

language of work or name

English

0 references

publication date

18 August 2006

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Proceedings of the National Academy of Sciences of the United States of America

29 December 2019

published in

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29 December 2019

volume

103

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29 December 2019

page(s)

13062-13067

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29 December 2019

issue

35

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Transition from rolling to firm adhesion can be mimicked by extension of integrin alphaLbeta2 in an intermediate affinity state

29 December 2019

cites work

1 reference

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8 July 2018

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The relative influence of metal ion binding sites in the I-like domain and the interface with the hybrid domain on rolling and firm adhesion by integrin alpha4beta7.

8 July 2018

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8 July 2018

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Rolling adhesion through an extended conformation of integrin alphaLbeta2 and relation to alpha I and beta I-like domain interaction

8 July 2018

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Activation of integrin beta-subunit I-like domains by one-turn C-terminal alpha-helix deletions

8 July 2018

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8 July 2018

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Locking the beta3 integrin I-like domain into high and low affinity conformations with disulfides

8 July 2018

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Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster

8 July 2018

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Structure of integrin alpha5beta1 in complex with fibronectin

8 July 2018

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Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation

8 July 2018

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Conformational regulation of integrin structure and function

8 July 2018

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Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation

8 July 2018

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Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand

8 July 2018

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Kinetic and mechanical basis of rolling through an integrin and novel Ca2+-dependent rolling and Mg2+-dependent firm adhesion modalities for the alpha 4 beta 7-MAdCAM-1 interaction

8 July 2018

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8 July 2018

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Crystal structure of the extracellular segment of integrin alpha Vbeta3

21 January 2018

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Ultrastructure and function of dimeric, soluble intercellular adhesion molecule-1 (ICAM-1).

8 July 2018

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Epitope mapping of antibodies to the C-terminal region of the integrin beta 2 subunit reveals regions that become exposed upon receptor activation

8 July 2018

1 reference

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Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains

8 July 2018

1 reference

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Geometry of metal-ligand interactions in proteins

8 July 2018

1 reference

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NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding

8 July 2018

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The structure of the beta-propeller domain and C-terminal region of the integrin alphaM subunit. Dependence on beta subunit association and prediction of domains.

8 July 2018

1 reference

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Folding of the beta-propeller domain of the integrin alphaL subunit is independent of the I domain and dependent on the beta2 subunit

8 July 2018

1 reference

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Efficient neutralization and disruption of rhinovirus by chimeric ICAM-1/immunoglobulin molecules.

8 July 2018

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Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)

8 July 2018

1 reference

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Activation of lymphocyte function-associated molecule-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) mimicked by an antibody directed against CD18.

8 July 2018

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Regulation of integrin alpha 5 beta 1-fibronectin interactions by divalent cations. Evidence for distinct classes of binding sites for Mn2+, Mg2+, and Ca2+.

8 July 2018

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Regulated expression of Mg2+ binding epitope on leukocyte integrin alpha subunits

8 July 2018

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Antibody against the Leu-CAM beta-chain (CD18) promotes both LFA-1- and CR3-dependent adhesion events

8 July 2018

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Divalent cation regulation of the function of the leukocyte integrin LFA-1

8 July 2018

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Role of ADMIDAS cation-binding site in ligand recognition by integrin alpha 5 beta 1.

8 July 2018

1 reference

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Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling

21 January 2018

1 reference

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Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins

21 January 2018

1 reference

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Small molecule integrin antagonists that bind to the beta2 subunit I-like domain and activate signals in one direction and block them in the other

21 January 2018

1 reference

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The role of the CPNKEKEC sequence in the beta(2) subunit I domain in regulation of integrin alpha(L)beta(2) (LFA-1).

21 January 2018

1 reference

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Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain

21 January 2018

1 reference

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Conformational Changes in the Integrin βA Domain Provide a Mechanism for Signal Transduction via Hybrid Domain Movement

21 January 2018

1 reference

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Does the integrin alphaA domain act as a ligand for its betaA domain?

21 January 2018

1 reference

12 December 2020

Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1)

1 reference

12 December 2020

Beta 2 (CD18) mutations abolish ligand recognition by I domain integrins LFA-1 (alpha L beta 2, CD11a/CD18) and MAC-1 (alpha M beta 2, CD11b/CD18)

1 reference

12 December 2020

The alpha subunit cytoplasmic domain regulates the assembly and adhesiveness of integrin lymphocyte function-associated antigen-1

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0605666103

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16920795%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16920795%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

1 reference