Centromere fission, not telomere erosion, triggers chromosomal instability in human carcinomas. (Q35020477)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21478459%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

review article

2 references

8 February 2021

Centromere fission, not telomere erosion, triggers chromosomal instability in human carcinomas (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21478459%20AND%20SRC:MED&resulttype=core&format=json

chromosome, centromeric region

28 January 2020

main subject

chromosome instability

1 reference

14 September 2019

1 reference

12 October 2019

1 reference

8 February 2021

1 reference

PubMed publication ID

21478459

author

Karel Hermanus Martinus van Wely

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21478459%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

author name string

Carlos Martínez-A

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21478459%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

language of work or name

English

0 references

publication date

8 April 2011

1 reference

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28 January 2020

1 June 2011

1 reference

8 February 2021

8

1 reference

inferred from page(s)

7 references

3 April 2019

20 June 2019

30 June 2019

14 September 2019

12 October 2019

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28 January 2020

8 February 2021

32

1 reference

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28 January 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21478459%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

page(s)

796-803

1 reference

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Creative Commons Attribution-NonCommercial

28 January 2020

copyright license

6 references

3 April 2019

20 June 2019

30 June 2019

14 September 2019

12 October 2019

8 February 2021

on focus list of Wikimedia project

ScienceSource

0 references

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Persistent telomere damage induces bypass of mitosis and tetraploidy

8 July 2018

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8 July 2018

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A paradox revealed: karyotype evolution in the four-horned antelope occurs by tandem fusion (Mammalia, Bovidae, Tetracerus quadricornis).

8 July 2018

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The landscape of somatic copy-number alteration across human cancers

8 July 2018

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Signatures of mutation and selection in the cancer genome

8 July 2018

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CENP-A reduction induces a p53-dependent cellular senescence response to protect cells from executing defective mitoses

8 July 2018

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Telomere-dependent and telomere-independent origins of endogenous DNA damage in tumor cells

8 July 2018

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Centromere-localized breaks indicate the generation of DNA damage by the mitotic spindle.

8 July 2018

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Telomerase upregulation is a postcrisis event during senescence bypass and immortalization of two Nijmegen breakage syndrome T cell cultures

8 July 2018

1 reference

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Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity

8 July 2018

1 reference

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Efficient repair of DNA double-strand breaks in malignant cells with structural instability

8 July 2018

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The role of aneuploidy in promoting and suppressing tumors

8 July 2018

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Detecting ATM-dependent chromatin modification in DNA damage and heat shock response

8 July 2018

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Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis

8 July 2018

1 reference

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The aneuploidy paradox in cell growth and tumorigenesis

8 July 2018

1 reference

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Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells

8 July 2018

1 reference

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Actions of human telomerase beyond telomeres

8 July 2018

1 reference

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8 July 2018

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Examining the link between chromosomal instability and aneuploidy in human cells

8 July 2018

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8 July 2018

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Human cancer cells commonly acquire DNA damage during mitotic arrest

8 July 2018

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Human chromosome fragility

8 July 2018

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8 July 2018

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8 July 2018

1 reference

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Endings in the middle: current knowledge of interstitial telomeric sequences

8 July 2018

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Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence

8 July 2018

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Telomerase expression in lung preneoplasia and neoplasia

8 July 2018

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The Stability of Broken Ends of Chromosomes in Zea Mays.

8 July 2018

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Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

8 July 2018

1 reference

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Molecular cytogenetic analysis of oral squamous cell carcinomas by comparative genomic hybridization, spectral karyotyping, and fluorescence in situ hybridization

8 July 2018

1 reference

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Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice

8 July 2018

1 reference

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Generating chromosome instability through the simultaneous deletion of Mad2 and p53.

8 July 2018

1 reference

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The interactive online SKY/M-FISH & CGH database and the Entrez cancer chromosomes search database: linkage of chromosomal aberrations with the genome sequence

8 July 2018

1 reference

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The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.

8 July 2018

1 reference

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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

8 July 2018

1 reference

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

8 July 2018

1 reference

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Centromeric chromosomal translocations show tissue-specific differences between squamous cell carcinomas and adenocarcinomas.

8 July 2018

1 reference

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Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B.

8 July 2018

1 reference

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Genomic instability in both wild-type and telomerase null MEFs

8 July 2018

1 reference

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8 July 2018

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8 July 2018

1 reference

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ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation

8 July 2018

1 reference

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Dysfunctional mammalian telomeres join with DNA double-strand breaks

8 July 2018

1 reference

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A DNA damage checkpoint response in telomere-initiated senescence

8 July 2018

1 reference

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8 July 2018

Common fragile sites.

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8 July 2018

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Mutations and aneuploidy: co-conspirators in cancer?

8 July 2018

1 reference

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Evolving views of telomerase and cancer

8 July 2018

1 reference

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Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression

8 July 2018

1 reference

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The random development of LOH on chromosome 9q in superficial bladder cancers.

8 July 2018

1 reference

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DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis

8 July 2018

1 reference

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Senescence Induced by Altered Telomere State, Not Telomere Loss

8 July 2018

1 reference

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Chromosome segregation and cancer: cutting through the mystery

8 July 2018

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8 July 2018

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Functional significance of concomitant inactivation of hMLH1 and hMSH6 in tumor cells of the microsatellite mutator phenotype.

8 July 2018

1 reference

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Cohesin cleavage by separase required for anaphase and cytokinesis in human cells

8 July 2018

1 reference

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Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells

8 July 2018

1 reference

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Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang

8 July 2018

1 reference

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Jumping translocations are common in solid tumor cell lines and result in recurrent fusions of whole chromosome arms

8 July 2018

1 reference

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Fusion of 9 beta-satellite and telomere (TTAGGG)n sequences results in a jumping translocation

8 July 2018

1 reference

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Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis

8 July 2018

1 reference

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DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes

8 July 2018

1 reference

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Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice

8 July 2018

1 reference

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Genetic instabilities in human cancers

8 July 2018

1 reference

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Telomerase expression in chickens: constitutive activity in somatic tissues and down-regulation in culture

8 July 2018

1 reference

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Genetic instability of cancer cells is proportional to their degree of aneuploidy

8 July 2018

1 reference

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Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity

8 July 2018

1 reference

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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

8 July 2018

1 reference

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Sequence of the FRA3B common fragile region: implications for the mechanism of FHIT deletion

8 July 2018

1 reference

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Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

8 July 2018

1 reference

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Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

8 July 2018

1 reference

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Break points in chromosome #1 abnormalities of 218 human neoplasms.

8 July 2018

1 reference

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Identification of a specific telomere terminal transferase activity in Tetrahymena extracts

8 July 2018

1 reference

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Multiple telomeric associations of a trisomic whole q arm of chromosome 1 in a child with acute lymphoblastic leukemia

8 July 2018

1 reference

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Stabilization of dicentric chromosomes in Saccharomyces cerevisiae by telomere addition to broken ends or by centromere deletion

8 July 2018

1 reference

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Are aneuploidy and chromosome breakage caused by a CINgle mechanism?

8 July 2018

1 reference

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Sustained mitotic block elicits DNA breaks: one-step alteration of ploidy and chromosome integrity in mammalian cells.

25 October 2018

1 reference

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Qualitative and quantitative analysis of phosphorylated ATM foci induced by low-dose ionizing radiation.

25 October 2018

1 reference

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BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106440

Instability of chromosome structure in cancer cells increases exponentially with degrees of aneuploidy

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106440

Molecular cytogenetic analysis of medulloblastomas and supratentorial primitive neuroectodermal tumors by using conventional banding, comparative genomic hybridization, and spectral karyotyping.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106440

Detection of chromosomal breakage in the 1cen-1q12 region of interphase human lymphocytes using multicolor fluorescence in situ hybridization with tandem DNA probes

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106440

The quinacrine fluorescent and Giemsa banding karyotype of the rat, Rattus norvegicus, and banded chromosome analysis of transformed and malignant rat liver cell lines

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106440

Molecular cytogenetic analysis of glial tumors using spectral karyotyping and comparative genomic hybridization

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3106440

Interstitial telomere repeats in translocations of hematopoietic disorders

9 December 2018

1 reference

12 December 2020

Cytogenetic studies of human breast cancer lines: MCF-7 and derived variant sublines

1 reference

12 December 2020

Spontaneous regression of cutaneous melanoma in sinclair swine is associated with defective telomerase activity and extensive telomere erosion

1 reference

12 December 2020

Fragile site and interstitial telomere repeat sequences at the fusion point of a de novo (Y;13) translocation

1 reference

12 December 2020

Telomeric structure in cells with chromosome end associations

1 reference

12 December 2020

Genome instability: McClintock revisited

1 reference

12 December 2020

Tumor specific modulation of KU70/80 DNA binding activity in breast and bladder human tumor biopsies

1 reference

12 December 2020

Characterization of centromere alterations in liposarcomas

1 reference

12 December 2020

An experimental approach to the analysis of mechanisms of meiotic nondisjunction and anaphase lagging in primary oocytes

1 reference

12 December 2020

Heterozygous deletion of mitotic arrest-deficient protein 1 (MAD1) increases the incidence of tumors in mice

1 reference

12 December 2020

A role for telomeric and centromeric instability in the progression of chromosome aberrations in meningioma patients

1 reference

12 December 2020

Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency

1 reference

12 December 2020

Fluorescence in situ hybridization with a synthetic (T2AG3)n polynucleotide detects several intrachromosomal telomere-like repeats on human chromosomes

1 reference

12 December 2020

Translocation (1;19)(q21;q13.3) is a recurrent reciprocal translocation in meningioma

1 reference

12 December 2020

Evidence for telomeric fusions as a mechanism for recurring structural aberrations of chromosome 11 in giant cell tumor of bone

1 reference

12 December 2020

Growth characteristics of the murine trisomy 19 thymus

1 reference

12 December 2020

Centromere-telomere (12;8p) fusion, telomeric 12q translocation, and i(12p) trisomy

1 reference

12 December 2020

Identifiers

DOI

10.1093/CARCIN/BGR069

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21478459%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21478459%20AND%20SRC:MED&resulttype=core&format=json

28 January 2020

PubMed publication ID

21478459

1 reference