Sterol regulatory element-binding protein family as global regulators of lipid synthetic genes in energy metabolism (Q35025259)

5 August 2017

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title

Sterol regulatory element-binding protein family as global regulators of lipid synthetic genes in energy metabolism (English)

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5 August 2017

1 reference

Hitoshi Shimano

1

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5 August 2017

1 January 2002

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5 August 2017

Vitamins and Hormones

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5 August 2017

65

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5 August 2017

167-194

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Promoter analysis of the mouse sterol regulatory element-binding protein-1c gene

5 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Promoter selective transcriptional synergy mediated by sterol regulatory element binding protein and Sp1: a critical role for the Btd domain of Sp1.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Sterol regulation of fatty acid synthase promoter. Coordinate feedback regulation of two major lipid pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Co-stimulation of promoter for low density lipoprotein receptor gene by sterol regulatory element-binding protein and Sp1 is specifically disrupted by the yin yang 1 protein

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Sterol regulatory element binding protein-1 activates the cholesteryl ester transfer protein gene in vivo but is not required for sterol up-regulation of gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Conditional response of the human steroidogenic acute regulatory protein gene promoter to sterol regulatory element binding protein-1a

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Sterol regulation of 3-hydroxy-3-methylglutaryl-coenzyme A synthase gene through a direct interaction between sterol regulatory element binding protein and the trimeric CCAAT-binding factor/nuclear factor Y.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

A critical role for cAMP response element-binding protein (CREB) as a Co-activator in sterol-regulated transcription of 3-hydroxy-3-methylglutaryl coenzyme A synthase promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junction as determined by cysteine panning

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Synergistic binding of sterol regulatory element-binding protein and NF-Y to the farnesyl diphosphate synthase promoter is critical for sterol-regulated expression of the gene

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Identification of glycerol-3-phosphate acyltransferase as an adipocyte determination and differentiation factor 1- and sterol regulatory element-binding protein-responsive gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

YY1 is a negative regulator of transcription of three sterol regulatory element-binding protein-responsive genes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Dietary regulation of gene expression: enzymes involved in carbohydrate and lipid metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Multiple sequence elements are involved in the transcriptional regulation of the human squalene synthase gene

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Sterol regulatory element-binding protein-1 is regulated by glucose at the transcriptional level.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Severe hypercholesterolemia, hypertriglyceridemia, and atherosclerosis in mice lacking both leptin and the low density lipoprotein receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Physiological and molecular mechanisms involved in nutritional regulation of fatty acid synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Multiple DNA elements for sterol regulatory element-binding protein and NF-Y are responsible for sterol-regulated transcription of the genes for human 3-hydroxy-3-methylglutaryl coenzyme A synthase and squalene synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Fish oil feeding decreases mature sterol regulatory element-binding protein 1 (SREBP-1) by down-regulation of SREBP-1c mRNA in mouse liver. A possible mechanism for down-regulation of lipogenic enzyme mRNAs

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Cholesterol biosynthesis from lanosterol. A concerted role for Sp1 and NF-Y-binding sites for sterol-mediated regulation of rat 7-dehydrocholesterol reductase gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N).

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Tumor necrosis factor-alpha stimulates the maturation of sterol regulatory element binding protein-1 in human hepatocytes through the action of neutral sphingomyelinase

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

cDNA cloning of human oxysterol-binding protein and localization of the gene to human chromosome 11 and mouse chromosome 19

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Two tandem binding sites for sterol regulatory element binding proteins are required for sterol regulation of fatty-acid synthase promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Different sterol regulatory element-binding protein-1 isoforms utilize distinct co-regulatory factors to activate the promoter for fatty acid synthase.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Sterol response element-binding protein 1c (SREBP1c) is involved in the polyunsaturated fatty acid suppression of hepatic S14 gene transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Structure of the human gene encoding sterol regulatory element binding protein 2 (SREBF2)

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

The roles of sterol regulatory element-binding proteins in the transactivation of the rat ATP citrate-lyase promoter.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Induction of fatty acid synthase and S14 gene expression by glucose, xylitol and dihydroxyacetone in cultured rat hepatocytes is closely correlated with glucose 6-phosphate concentrations.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Genomic structure and chromosomal mapping of the human sterol regulatory element binding protein (SREBP) cleavage-activating protein (SCAP) gene

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Molecular cloning of the promoter for rat hepatic neutral cholesterol ester hydrolase: evidence for transcriptional regulation by sterols

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Co-crystal structure of sterol regulatory element binding protein 1a at 2.3 A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Translocation of oxysterol binding protein to Golgi apparatus triggered by ligand binding

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Cyclic adenosine 3',5'-monophosphate(cAMP)/cAMP-responsive element modulator (CREM)-dependent regulation of cholesterogenic lanosterol 14alpha-demethylase (CYP51) in spermatids.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Sterol regulatory element-binding proteins induce an entire pathway of cholesterol synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Cooperation by sterol regulatory element-binding protein and Sp1 in sterol regulation of low density lipoprotein receptor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Sterol-dependent transcriptional regulation of sterol regulatory element-binding protein-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Sterol regulatory element-binding protein negatively regulates microsomal triglyceride transfer protein gene transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Transcriptional regulation of the ATP citrate-lyase gene by sterol regulatory element-binding proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Induction of LPL gene expression by sterols is mediated by a sterol regulatory element and is independent of the presence of multiple E boxes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Role of LXRs in control of lipogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

ABC1 gene expression and ApoA-I-mediated cholesterol efflux are regulated by LXR.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Yin yang 1 protein negatively regulates high-density lipoprotein receptor gene transcription by disrupting binding of sterol regulatory element binding protein to the sterol regulatory element

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Sterol regulatory element binding protein-1a regulation of the steroidogenic acute regulatory protein gene

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Increased high density lipoprotein (HDL), defective hepatic catabolism of ApoA-I and ApoA-II, and decreased ApoA-I mRNA in ob/ob mice. Possible role of leptin in stimulation of HDL turnover

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy status

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Identification of diazepam-binding Inhibitor/Acyl-CoA-binding protein as a sterol regulatory element-binding protein-responsive gene

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Transcriptional activation of the stearoyl-CoA desaturase 2 gene by sterol regulatory element-binding protein/adipocyte determination and differentiation factor 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Oleate potentiates oxysterol inhibition of transcription from sterol regulatory element-1-regulated promoters and maturation of sterol regulatory element-binding proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element-binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Polyunsaturated fatty acids suppress hepatic sterol regulatory element-binding protein-1 expression by accelerating transcript decay

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

A Crucial Role of Sterol Regulatory Element-binding Protein-1 in the Regulation of Lipogenic Gene Expression by Polyunsaturated Fatty Acids

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

Sterol regulatory element binding proteins (SREBPs): controllers of lipid synthesis and cellular uptake

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2802%2965064-2

7 January 2021

10.1016/S0083-6729(02)65064-2

Identifiers

DOI

1 reference

5 August 2017

1 reference

PubMed ID

12481547