Predicting pharmacokinetics and drug interactions in patients from in vitro and in vivo models: the experience with 5,6-dimethylxanthenone-4-acetic acid (DMXAA), an anti-cancer drug eliminated mainly by conjugation. (Q35027930)

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English	Predicting pharmacokinetics and drug interactions in patients from in vitro and in vivo models: the experience with 5,6-dimethylxanthenone-4-acetic acid (DMXAA), an anti-cancer drug eliminated mainly by conjugation.	scientific article

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Predicting pharmacokinetics and drug interactions in patients from in vitro and in vivo models: the experience with 5,6-dimethylxanthenone-4-acetic acid (DMXAA), an anti-cancer drug eliminated mainly by conjugation (English)

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pharmacokinetics

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based on heuristic

inferred from title

James W. Paxton

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Shufeng Zhou

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Philip Kestell

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1 November 2002

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Drug Metabolism Reviews

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751-790

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15 December 2019

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Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

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Antitumour activity of the novel immune modulator 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in mice lacking the interferon-gamma receptor.

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Effect of flavone acetic acid (NSC 347,512) on splenic cytotoxic effector cells and their role in tumour necrosis.

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Species differences in the metabolism of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid in vitro: implications for prediction of metabolic interactions in vivo

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Drug glucuronidation by human renal UDP-glucuronosyltransferases.

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Biological basis for extrapolation across mammalian species.

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Identifiers

10.1081/DMR-120015693

1 reference

Europe PubMed Central

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15 December 2019

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15 December 2019

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