The dynamic conformational landscape of gamma-secretase. (Q35029189)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25501811%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

title

The dynamic conformational landscape of gamma-secretase (English)

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24 February 2020

1

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24 February 2020

Wim J H Hagen

4

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24 February 2020

Carsten Sachse

9

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24 February 2020

author name string

Sam Lismont

3

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24 February 2020

Sarah Veugelen

5

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24 February 2020

Muriel Arimon

6

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24 February 2020

Katrien Horré

7

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24 February 2020

Oksana Berezovska

8

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24 February 2020

Lucía Chávez-Gutiérrez

10

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24 February 2020

Bart De Strooper

2

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24 February 2020

language of work or name

English

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publication date

1 February 2015

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24 February 2020

published in

Journal of Cell Science

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24 February 2020

volume

128

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24 February 2020

issue

3

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24 February 2020

page(s)

589-598

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Creative Commons Attribution 3.0 Unported

24 February 2020

copyright license

start time

17 September 2020

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Novel research horizons for presenilins and γ-secretases in cell biology and disease

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

https://pubmed.ncbi.nlm.nih.gov/25501811

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Accurate determination of local defocus and specimen tilt in electron microscopy

1 reference

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Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

8 July 2018

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Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

8 July 2018

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

8 July 2018

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

8 July 2018

1 reference

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The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

8 July 2018

1 reference

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Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

8 July 2018

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SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fields

8 July 2018

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8 July 2018

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8 July 2018

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Three-dimensional reconstruction from a single-exposure, random conical tilt series applied to the 50S ribosomal subunit of Escherichia coli

8 July 2018

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Modification of γ-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease

8 July 2018

1 reference

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Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex

25 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311135

Nicastrin functions as a gamma-secretase-substrate receptor

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311135

Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein.

25 October 2018

1 reference

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Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation

25 October 2018

1 reference

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Designed Helical Peptides Inhibit an Intramembrane Protease

25 October 2018

1 reference

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Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311135

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311135

Three-dimensional structure of the γ-secretase complex

25 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25501811

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1242/JCS.164384

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25501811%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25501811%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

PubMed publication ID

25501811

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25501811%20AND%20SRC:MED&resulttype=core&format=json